Detailed view for LOAG_08123

Basic information

TDR Targets ID: 935452
Loa Loa (eye worm), major facilitator superfamily transporter

Source Database / ID:  KEGG  

pI: 9.4832 | Length (AA): 574 | MW (Da): 63935 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 115 4zp0 (A) 19 121 19.00 0.000038 0.48 0.407285 -0.02
18 445 4lds (A) 16 427 14.00 0 0.86 0.815745 0.82
36 456 4j05 (A) 62 514 28.00 0.0024 0.73 0.731649 0.77
210 376 5a8w (B) 268 409 31.00 0.75 0.16 0.0661408 1.93
440 558 4mkm (A) 186 297 12.00 0 0.01 0.321517 -0.98
442 559 5dje (A) 23 140 12.00 0 0 0.490775 -2.08
461 574 2hkd (A) 155 266 18.00 0 0.03 0.433806 -1.5
476 570 2fkj (A) 129 221 35.00 0.27 0.02 0.531705 -1.52
519 574 5wst (A) 863 918 20.00 0 0.01 0.707761 -4.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_160662)

Species Accession Gene Product
Brugia malayi Bm1_51575   Major Facilitator Superfamily protein
Brugia malayi Bm1_51570   Major Facilitator Superfamily protein
Caenorhabditis elegans CELE_T01B11.7   Protein OAT-1
Loa Loa (eye worm) LOAG_08123   major facilitator superfamily transporter
Loa Loa (eye worm) LOAG_10089   hypothetical protein
Loa Loa (eye worm) LOAG_00054   major facilitator superfamily transporter
Onchocerca volvulus OVOC7905  
Onchocerca volvulus OVOC11985  
Onchocerca volvulus OVOC11986  
Onchocerca volvulus OVOC11609  
Onchocerca volvulus OVOC11963  
Onchocerca volvulus OVOC6873  
Onchocerca volvulus OVOC6874  
Onchocerca volvulus OVOC6872  
Onchocerca volvulus OVOC11983  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Solute carrier family 22 member 12 553 aa 22.0% 468 aa Compounds References
Rattus norvegicus Solute carrier family 22 member 8 536 aa 23.6% 454 aa Compounds References
Rattus norvegicus Solute carrier family 22 member 7 535 aa 23.7% 435 aa Compounds References
Rattus norvegicus Solute carrier family 22 member 6 551 aa 24.8% 443 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0744 0.3371 0.6443
0.0708 0.6913 1
0.0006 0.5 0.5
0.0026 0.2589 1
0.089 0.2727 1
0.0802 0.3726 1
0.0934 0.3952 1
0.0684 0.661 1
0.0808 0.4976 1
0.0905 0.392 1
0.0072 0.5 0.5
0.0805 0.3768 1
0.0938 0.3795 1
0.0902 0.3872 1
0.0372 0.3723 1
0.0746 0.2979 1
0.0855 0.4048 1
0.0737 0.7131 1
0.0785 0.7428 1
0.0886 0.3725 1
0.092 0.3639 1
0.0902 0.384 1
0.0115 0.8254 0.8254
0.0778 0.2723 0.265
0.0681 0.282 1
0.0852 0.3794 1
0.0676 0.4278 0.427
0.0725 0.3007 1
0.0912 0.3836 1
0.0851 0.3655 1
0.0906 0.4211 0.6835
0.0904 0.385 1
0.0808 0.3589 1
0.0849 0.3822 1
0.0801 0.5193 0.8953
0.0242 1 1
0.0932 0.3859 1
0.0933 0.3903 1
0.0861 0.3665 1
0.0784 0.766 1
0.0703 0.282 1
0.0019 0.3675 1
0.0869 0.3805 1
0.0911 0.3866 1
0.0104 0.4448 0.4448
0.088 0.3774 1
0.09 0.368 1
0.0832 0.3853 1
0.0898 0.388 1
0.0919 0.3894 1
0.0883 0.4017 1
0.0847 0.3728 1
0.0006 0.5 0.5
0.0779 0.2877 1
0.0565 0.513 0.8918
0.0808 0.7747 1
0.0699 0.3137 1
0.0878 0.4008 0.7686
0.0863 0.3613 1
0.0759 0.7344 1
0.0692 0.2863 1
0.0778 0.2723 0.265
0.0888 0.4111 1
0.0856 0.3829 1
0.0852 0.3669 1
0.0891 0.3748 1
0.0701 0.6657 1
0.0872 0.3682 1
0.0786 0.3708 1
0.0006 0.5 0.5
0.0862 0.3709 1
0.0859 0.3889 1
0.0808 0.3589 1
0.0909 0.3804 1
0.0801 0.5193 0.8953
0.0911 0.3937 1
0.0026 0.4542 0.4542
0.0757 0.2571 0.5231
0.0086 0.5 0.5
0.0785 0.3546 1
0.0955 0.3879 1
0.0801 0.3587 1
0.0919 0.4066 1
0.0604 0.5795 1
0.0661 0.3105 1
0.0882 0.383 1
0.0693 0.2676 1
0.0859 0.3676 1
0.0954 0.378 1
0.0822 0.3544 1
0.0152 0.339 0.7702
0.09 0.3856 1
0.0778 0.2723 0.265
0.0115 0.8254 0.8254
0.0746 0.2979 1
0.0473 0.4582 1
0.0811 0.3835 1
0.0026 0.5 0.5
0.0825 0.395 1
0.0908 0.4056 1
0.0855 0.3965 1
0.0649 0.5 0.5
0.0904 0.388 1
0.08 0.3562 1
0.0931 0.4131 1
0.0839 0.3687 1
0.0856 0.3899 1
0.0877 0.3703 1
0.0691 0.6563 1
0.0867 0.3611 1
0.0933 0.3971 1
0.082 0.3993 1
0.0887 0.3854 1
0.0838 0.798 1
0.0825 0.381 1
0.0006 0.5 0.5
0.0017 0.5 0.5
0.0676 0.4278 0.427
0.0885 0.38 1
0.0846 0.3834 1
0.0761 0.7227 1
0.0788 0.3469 1
0.0771 0.3215 1
0.0906 0.3708 1
0.0917 0.76 1
0.0815 0.3701 1
0.0814 0.3388 1
0.0904 0.3997 1
0.0705 0.673 1
0.0693 0.3086 1
0.0701 0.6673 0.9194
0.0891 0.4065 1
0.086 0.4118 1
0.0828 0.3611 1
0.0614 0.4905 0.5316
0.0026 0.5 0.5
0.0785 0.3546 1
0.0869 0.3613 1
0.0443 0.5 0.5
0.0124 0.5 0.5
0.0731 0.7159 1
0.0006 0.5 0.5
0.0662 0.6327 1
0.0766 0.3381 1
0.0937 0.3983 1
0.0006 0.5 0.5
0.0395 0.4327 1
0.0901 0.3833 1
0.0215 1 1
0.0835 0.7944 1
0.0006 0.5 0.5
0.0879 0.3794 1
0.0006 0.5 0.5
0.0676 0.4278 0.427
0.0788 0.3469 1
0.0848 0.3654 1
0.0779 0.7604 1
0.0218 0.2749 0.674
0.0906 0.4211 0.6835
0.0824 0.7893 1
0.0705 0.2788 1
0.0866 0.3965 1
0.0934 0.355 1
0.0859 0.3771 1
0.0931 0.4131 1
0.0801 0.3419 1
0.0967 0.3866 1
0.0854 0.368 1
0.0052 0.3137 0.3029
0.0602 0.2622 1
0.0006 0.5 0.5
0.0885 0.3952 1
0.001 0.5 0.5
0.0006 0.5 0.5
0.0851 0.3655 1
0.0731 0.6098 1
0.0947 0.3919 1
0.0931 0.3822 1
0.0916 0.4286 1
0.0945 0.3769 1
0.0858 0.3951 1
0.0789 0.351 1
0.0906 0.3653 1
0.038 0.5 0.5
0.0881 0.4196 1
0.0006 0.5 0.5
0.0893 0.3833 1
0.0836 0.4016 1
0.0578 0.5 0.5
0.0913 0.4084 1
0.0872 0.3879 1
0.0902 0.3808 1
0.0731 0.7159 1
0.0766 0.3381 1
0.0016 0.5 0.5
0.0924 0.363 1
0.0782 0.3584 1
0.0636 0.5945 1
0.0943 0.4376 1
0.0778 0.2723 0.265
0.0875 0.4019 1
0.0858 0.401 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_08123 (Loa Loa (eye worm)), major facilitator superfamily transporter
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