Detailed view for LOAG_04870

Basic information

TDR Targets ID: 940230
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.8967 | Length (AA): 1702 | MW (Da): 193745 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF00439   Bromodomain
PF06507   Auxin response factor

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0005515   protein binding  
GO:0003677   DNA binding  
GO:0009725   response to hormone stimulus  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
108 234 3frx (A) 18 140 24.00 0.089 0.21 0.222218 0.53
143 507 5gxi (A) 319 710 21.00 0.0053 0.99 0.380154 0.43
162 426 4j87 (A) 4 310 25.00 0.0000002 1 0.320399 0.25
185 564 3sfz (A) 818 1213 27.00 0.0000000000069 1 0.168967 1.54
191 519 3mkq (A) 3 310 12.00 0 0.94 0.333502 -0.3
199 233 4u7a (A) 435 469 40.00 0.52 0.45 0.410264 0.45
447 519 4i79 (A) 181 261 38.00 0.0096 0.78 0.336591 0.54
1097 1209 3qzt (A) 68 169 32.00 0.0000024 1 0.472092 -0.96
1109 1213 4cos (A) 150 253 23.00 0.000000000055 1 0.564292 -1.93
1111 1216 5mlj (A) 731 836 26.00 0 1 0.56888 -1.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129383)

Species Accession Gene Product
Arabidopsis thaliana AT5G49430   WD40/YVTN repeat and Bromo-WDR9-I-like domain-containing protein
Arabidopsis thaliana AT2G47410   WD40 domain-containing protein
Brugia malayi Bm1_28055   Bromodomain containing protein
Dictyostelium discoideum DDB_G0285837   BRWD group protein
Drosophila melanogaster Dmel_CG31132   CG31132 gene product from transcript CG31132-RA
Entamoeba histolytica EHI_176990   hypothetical protein
Homo sapiens ENSG00000185658   bromodomain and WD repeat domain containing 1
Homo sapiens ENSG00000165288   bromodomain and WD repeat domain containing 3
Homo sapiens ENSG00000146247   pleckstrin homology domain interacting protein
Loa Loa (eye worm) LOAG_04870   hypothetical protein
Mus musculus ENSMUSG00000022914   bromodomain and WD repeat domain containing 1
Mus musculus ENSMUSG00000032253   pleckstrin homology domain interacting protein
Mus musculus ENSMUSG00000063663   bromodomain and WD repeat domain containing 3
Oryza sativa 9268022   Os03g0306301
Onchocerca volvulus OVOC12900  
Onchocerca volvulus OVOC1496  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_04870 (Loa Loa (eye worm)), hypothetical protein
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