pI: 6.4081 |
Length (AA): 342 |
MW (Da): 40027 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 336 | 1t5o (A) | 12 | 340 | 16.00 | 0 | 1 | 0.96 | -0.35 |
13 | 325 | 1vb5 (A) | 4 | 272 | 17.00 | 0 | 1 | 1.03 | -0.38 |
17 | 334 | 2a0u (A) | 50 | 379 | 12.00 | 0 | 0.97 | 0.93 | -0.51 |
1 | 337 | 2yvk (A) | 18 | 349 | 17.00 | 0 | 1 | 1.00278 | 0.18 |
7 | 342 | 4zem (A) | 16 | 413 | 15.00 | 0 | 1 | 1.13336 | 0.02 |
120 | 327 | 1vb5 (A) | 78 | 275 | 25.00 | 0.000029 | 1 | 0.925487 | -0.7 |
149 | 336 | 3ecs (A) | 118 | 305 | 35.00 | 0 | 1 | 0.917008 | -0.7 |
178 | 335 | 1w2w (B) | 223 | 411 | 16.00 | 0 | 0.72 | 0.260388 | 0.59 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, gametocyte, early schizont, late trophozoite, Sporozoite, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, sporozoite, early trophozoite, late schizont, Oocyst, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Ring. | Zanghi G |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127805)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G53900 | eukaryotic translation initiation factor 2B family protein |
Arabidopsis thaliana | AT1G53880 | eukaryotic translation initiation factor 2B-like protein |
Arabidopsis thaliana | AT1G72340 | eukaryotic translation initiation factor 2B domain-containing protein |
Brugia malayi | Bm1_21890 | Initiation factor 2 subunit family protein |
Candida albicans | CaO19_6904 | hypothetical protein |
Candida albicans | CaO19.6904 | similar to S. cerevisiae GCN3 (YKR026C) delta subunit of eIF-2B, the guanine nucleotide exchange factor for translation initiati |
Caenorhabditis elegans | CELE_ZK1098.4 | Protein ZK1098.4 |
Cryptosporidium hominis | Chro.10211 | translation initiation factor EIF-2b alpha subunit |
Cryptosporidium parvum | cgd1_1860 | GCN3p like EIF2B,translation initiation factor eIF-2B alpha subunit |
Dictyostelium discoideum | DDB_G0288961 | translation initiation factor eIF-2B alpha subunit |
Drosophila melanogaster | Dmel_CG7883 | CG7883 gene product from transcript CG7883-RA |
Echinococcus granulosus | EgrG_001069100 | translation initiation factor eIF 2B subunit |
Entamoeba histolytica | EHI_096380 | translation initiation factor eIF-2B alpha subunit, putative |
Echinococcus multilocularis | EmuJ_001069100 | translation initiation factor eIF 2B subunit |
Giardia lamblia | GL50803_91911 | Translation initiation factor eIF-2B alpha subunit |
Homo sapiens | 1967 | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa |
Leishmania braziliensis | LbrM.12.0020 | translation initiation factor EIF-2b alpha subunit, putative |
Leishmania donovani | LdBPK_120010.1 | translation initiation factor EIF-2b alpha subunit, putative |
Leishmania infantum | LinJ.12.0001 | translation initiation factor EIF-2b alpha subunit, putative |
Leishmania major | LmjF.12.0010 | translation initiation factor EIF-2b alpha subunit, putative |
Leishmania mexicana | LmxM.12.0010 | translation initiation factor EIF-2b alpha subunit, putative |
Loa Loa (eye worm) | LOAG_08671 | initiation factor 2 subunit family protein |
Mus musculus | ENSMUSG00000029388 | eukaryotic translation initiation factor 2B, subunit 1 (alpha) |
Neospora caninum | NCLIV_011760 | hypothetical protein |
Oryza sativa | 4352258 | Os12g0497400 |
Plasmodium berghei | PBANKA_0702200 | translation initiation factor eIF-2B subunit alpha, putative |
Plasmodium falciparum | PF3D7_0828500 | translation initiation factor eIF-2B subunit alpha, putative |
Plasmodium knowlesi | PKNH_1322600 | translation initiation factor eIF-2B subunit alpha, putative |
Plasmodium vivax | PVX_088930 | translation initiation factor EIF-2b alpha subunit, putative |
Plasmodium yoelii | PY07384 | Initiation factor 2 subunit family, putative |
Saccharomyces cerevisiae | YKR026C | translation initiation factor eIF2B subunit alpha |
Schistosoma japonicum | Sjp_0027200 | ko:K03239 translation initiation factor eIF-2B alpha subunit, putative |
Schistosoma mansoni | Smp_084900 | translation initiation factor EIF-2b alpha subunit |
Schmidtea mediterranea | mk4.007895.01 | Probable translation initiation factor eIF-2B subunit alpha |
Schmidtea mediterranea | mk4.005423.00 | Probable translation initiation factor eIF-2B subunit alpha |
Trypanosoma brucei gambiense | Tbg972.6.990 | translation initiation factor EIF-2b alpha subunit, putative,eIF-2B GDP-GTP exchange factor |
Trypanosoma brucei | Tb927.6.1280 | translation initiation factor EIF-2b alpha subunit, putative |
Trypanosoma congolense | TcIL3000_0_44430 | translation initiation factor EIF-2b alpha subunit, putative |
Trypanosoma cruzi | TcCLB.507603.20 | translation initiation factor EIF-2b alpha subunit, putative |
Trypanosoma cruzi | TcCLB.509429.90 | translation initiation factor EIF-2b alpha subunit, putative |
Toxoplasma gondii | TGME49_211230 | eukaryotic initiation factor-2B, alpha subunit, putative |
Trichomonas vaginalis | TVAG_118970 | translation initiation factor eif-2B beta subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.1280 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.1280 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.1280 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.1280 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0702200 | Plasmodium berghei | Slow | plasmo |
TGME49_211230 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Pfal005257; Recombinant protein: full-length; Source: P falciparum; translation initiation factor EIF-2b alpha subunit, putative ; |