Detailed view for LOAG_01139

Basic information

TDR Targets ID: 945497
Loa Loa (eye worm), HAD-superfamily hydrolase
Source Database / ID:  KEGG  

pI: 9.4941 | Length (AA): 260 | MW (Da): 29738 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13419   Haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 260 3umg (A) 5 247 14.00 0 1 1.09898 -0.36
31 260 3k1z (A) 7 242 33.00 0 1 1.32272 -0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128559)

Species Accession Gene Product
Arabidopsis thaliana AT5G44730   haloacid dehalogenase-like hydrolase domain-containing protein
Arabidopsis thaliana AT1G14310   haloacid dehalogenase-like hydrolase domain-containing protein
Arabidopsis thaliana AT2G41250   haloacid dehalogenase-like hydrolase domain-containing protein
Brugia malayi Bm1_06935   HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein
Candida albicans CaO19.2076   similar to S. cerevisiae YMR130W
Candida albicans CaO19.9623   similar to S. cerevisiae YMR130W
Caenorhabditis elegans CELE_K01G5.10   Protein K01G5.10
Dictyostelium discoideum DDB_G0287017   hypothetical protein
Drosophila melanogaster Dmel_CG15912   CG15912 gene product from transcript CG15912-RA
Drosophila melanogaster Dmel_CG3200   Rhythmically expressed gene 2
Echinococcus granulosus EgrG_000379800   haloacid dehalogenase hydrolase
Echinococcus multilocularis EmuJ_000379800   haloacid dehalogenase hydrolase
Homo sapiens ENSG00000119431   haloacid dehalogenase-like hydrolase domain containing 3
Loa Loa (eye worm) LOAG_01139   HAD-superfamily hydrolase
Mus musculus ENSMUSG00000038422   haloacid dehalogenase-like hydrolase domain containing 3
Oryza sativa 9269048   Os03g0356498
Oryza sativa 4341776   Os06g0665100
Oryza sativa 4344169   Os07g0659400
Oryza sativa 4344766   Os08g0169800
Onchocerca volvulus OVOC8988  
Saccharomyces cerevisiae YMR130W   hypothetical protein

Essentiality

LOAG_01139 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K01G5.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_K01G5.10 Caenorhabditis elegans larval arrest wormbase
CELE_K01G5.10 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_01139 (Loa Loa (eye worm)), HAD-superfamily hydrolase
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