Detailed view for LOAG_07137

Basic information

TDR Targets ID: 947510
Loa Loa (eye worm), oxidoreductase
Source Database / ID:  KEGG  

pI: 7.3213 | Length (AA): 268 | MW (Da): 29691 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Folate biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 268 3ai3 (A) 1 257 25.00 0 1 1.29 -0.44
5 267 4xwy (A) 3 257 36.00 0 1 1.47774 -1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131569)

Species Accession Gene Product
Brugia malayi Bm1_29970   oxidoreductase, short chain dehydrogenase/reductase family protein
Dictyostelium discoideum DDB_G0290009   sepiapterin reductase
Drosophila melanogaster Dmel_CG12117   Sepiapterin reductase
Echinococcus granulosus EgrG_001041150   hypothetical protein
Echinococcus multilocularis EmuJ_001041150   conserved hypothetical protein
Homo sapiens ENSG00000116096   sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Loa Loa (eye worm) LOAG_07137   oxidoreductase
Mus musculus ENSMUSG00000033735   sepiapterin reductase
Neospora caninum NCLIV_031930   sepiapterin reductase, putative
Onchocerca volvulus OVOC8233   Sepiapterin reductase homolog
Schmidtea mediterranea mk4.000668.03   Sepiapterin reductase
Toxoplasma gondii TGME49_231920   oxidoreductase, short chain dehydrogenase/reductase family protein

Essentiality

LOAG_07137 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_231920 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 26.9% 156 aa Compounds References
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] 258 aa 22.0% 264 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.007 1 1
0.0013 1 1
0.0035 1 1
0.0009 1 0.5
0.016 0.577 1
0.0073 0.2873 0.2873
0.0073 0.3141 1
0.0009 0.5 0.5
0.0021 0.3321 0.3321
0.0119 0.2746 1
0.0056 0.875 0.875
0.0332 1 1
0.0005 0.5 0.5
0.0088 0.6544 0.6544
0.007 0.2916 0.4349
0.0624 1 1
0.0084 0.4283 0.4283
0.0165 1 1
0.0005 0.5 0.5
0.0076 1 1
0.0114 1 1
0.0004 0.5 0.5
0.0085 1 1
0.0171 0.4063 0.4063
0.0009 0.7374 0.7374
0.008 0.5 0.5
0.0009 0.5 0.5
0.0131 0.5 0.5
0.016 0.577 1
0.0093 0.5 0.5
0.0218 0.5 0.5
0.0073 0.3811 0.3811
0.0073 0.3811 0.3811
0.0004 0.5 0.5
0.007 1 1
0.0097 1 1
0.007 0.2916 0.4349
0.0402 1 1
0.0222 0.5 0.5
0.0053 1 1
0.0056 1 1
0.0157 0.5 0.5
0.007 1 1
0.0009 0.5 0.5
0.0073 0.4546 0.4546
0.0408 0.5144 1
0.0082 1 0.5
0.0009 0.5 0.5
0.0132 0.3658 0.3658
0.0196 0.8679 0.8679
0.0032 1 1
0.0118 1 1
0.0106 0.5 0.5
0.0004 0.5 0.5
0.0053 1 1
0.0009 0.5 0.5
0.0089 0.5 0.5
0.0004 0.5 0.5
0.0058 0.3931 0.5176
0.011 0.3568 0.3568
0.004 0.5 0.5
0.0009 0.5 0.5
0.0012 0.5 0.5
0.0021 0.3321 0.3321
0.0058 1 1
0.0016 0.5 0.5
0.0064 0.3508 0.411
0.0019 0.4322 1
0.0057 0.284 0.2719
0.0004 0.5 0.5
0.0046 0.3082 0.3082
0.0106 1 1
0.0068 1 1
0.0097 0.4304 1
0.0123 0.5 0.5
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0021 0.5 0.5
0.0408 0.5144 1
0.0089 0.5 0.5
0.0013 0.5 0.5
0.0012 0.5 0.5
0.0108 0.5 0.5
0.0066 0.3586 0.3586
0.0196 0.8679 0.8679
0.007 0.2916 0.4349
0.0068 0.2585 0.4116
0.0068 1 1
0.0009 0.5 0.5
0.0027 0.5 0.5
0.0067 0.3468 0.3468
0.0113 1 1
0.0162 1 1
0.0045 1 1
0.0026 0.5 0.5
0.0196 0.8679 0.8679
0.0408 0.5144 1
0.0106 1 1
0.0004 0.5 0.5
0.0171 0.4063 0.4063
0.0102 0.7451 0.1796
0.0088 1 1
0.0106 0.2872 0.4415
0.0114 1 1
0.0071 0.3141 0.3141
0.0009 0.5 0.5
0.0087 0.5 0.5
0.0039 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_07137 (Loa Loa (eye worm)), oxidoreductase
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