Detailed view for MUL_5066

Basic information

TDR Targets ID: 954857
Mycobacterium ulcerans, thioredoxin reductase TrxB2
Source Database / ID:  KEGG  

pI: 4.3859 | Length (AA): 332 | MW (Da): 35211 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07992   Pyridine nucleotide-disulphide oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0016491   oxidoreductase activity  
GO:0004791   thioredoxin-disulfide reductase activity  
GO:0019430   removal of superoxide radicals  
GO:0055114   oxidation reduction  

Metabolic Pathways

Pyrimidine metabolism (KEGG)
Selenoamino acid metabolism (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 319 2a87 (A) 10 322 89.00 0 1 1.99797 -0.87
12 49 5buk (A) 5 42 47.00 0.0016 0.21 0.487358 0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127532)

Species Accession Gene Product
Arabidopsis thaliana AT2G41680   NADPH-dependent thioredoxin reductase C
Arabidopsis thaliana AT2G17420   NADPH-dependent thioredoxin reductase A
Arabidopsis thaliana AT4G35460   thioredoxin reductase 1
Candida albicans CaO19.4290   single gene similar to S. cerevisiae TRR1 (YDR353W) and TRR2 (YHR106W) cytoplasmic and mitochondrial thioredoxin reductases
Candida albicans CaO19.11766   single gene similar to S. cerevisiae TRR1 (YDR353W) and TRR2 (YHR106W) cytoplasmic and mitochondrial thioredoxin reductases
Chlamydia trachomatis CT_099   thioredoxin reductase
Dictyostelium discoideum DDB_G0280815   thioredoxin reductase
Escherichia coli b0888   thioredoxin reductase, FAD/NAD(P)-binding
Entamoeba histolytica EHI_155440   thioredoxin reductase, putative
Giardia lamblia GL50803_9827   Thioredoxin reductase
Mycobacterium leprae ML2703   THIOREDOXIN TRXC (TRX) (MPT46)
Mycobacterium tuberculosis Rv3913   Probable thioredoxin reductase TrxB2 (TRXR) (TR)
Mycobacterium ulcerans MUL_5066   thioredoxin reductase TrxB2
Oryza sativa 4330505   Os02g0713400
Oryza sativa 4340912   Os06g0327300
Oryza sativa 4344159   Os07g0657900
Saccharomyces cerevisiae YHR106W   thioredoxin-disulfide reductase TRR2
Saccharomyces cerevisiae YDR353W   thioredoxin-disulfide reductase TRR1
Treponema pallidum TP0814   thioredoxin reductase (trxB)
Trichomonas vaginalis TVAG_125360   disulfide oxidoreductase, putative
Trichomonas vaginalis TVAG_474980   dihydrolipoamide dehydrogenase, putative
Trichomonas vaginalis TVAG_240530   disulfide oxidoreductase, putative
Trichomonas vaginalis TVAG_281360   disulfide oxidoreductase, putative
Trichomonas vaginalis TVAG_348010   disulfide oxidoreductase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0566   thioredoxin reductase

Essentiality

MUL_5066 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3980 Mycobacterium tuberculosis essential nmpdr
b0888 Escherichia coli non-essential goodall
YDR353W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Escherichia coli thioredoxin reductase, FAD/NAD(P)-binding Compounds References
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) Compounds References
Entamoeba histolytica thioredoxin reductase, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1958 1 0.5
0.0302 0.3489 1
0.0323 0.3474 1
0.1958 1 0.5
0.0462 0.729 1
0.2076 1 1
0.0144 0.3963 1
0.0173 0.5884 1
0.2066 1 1
0.0674 0.2955 1
0.0684 0.2531 1
0.0649 0.4288 0.6766
0.0139 0.5338 1
0.0621 0.6816 1
0.0153 0.419 1
0.0178 0.886 0.5
0.0289 1 1
0.0309 0.3473 1
0.0148 0.2738 1
0.0674 0.2955 1
0.1868 1 1
0.0328 0.3574 1
0.0674 0.2955 1
0.0627 0.6547 1
0.0683 0.2794 1
0.2074 1 1
0.1825 1 1
0.0297 0.3641 1
0.0152 0.259 1
0.0319 0.3594 1
0.0307 0.3598 1
0.0139 0.2791 1
0.2043 1 1
0.0309 0.3694 1
0.0178 0.886 0.5
0.0674 0.2955 1
0.0171 0.3106 0.99
0.2034 1 1
0.0155 0.2614 1
0.0309 0.3473 1
0.0152 0.259 1
0.0171 0.2813 0.9341
0.2066 1 1
0.0674 0.2955 1
0.0145 0.3956 1
0.0145 0.3269 1
0.1837 1 1
0.0143 0.3844 1
0.0161 0.4066 1
0.0144 0.3052 1
0.1998 1 1
0.0684 0.2531 1
0.0311 0.348 1
0.2076 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier MUL_5066 (Mycobacterium ulcerans), thioredoxin reductase TrxB2
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