Detailed view for EmuJ_000885600

Basic information

TDR Targets ID: 956287
Echinococcus multilocularis, potassium channel subfamily K 8
Source Database / ID:  GeneDB

pI: 4.8279 | Length (AA): 554 | MW (Da): 62094 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07885   Ion channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0071805   GO:potassium ion transmembrane transport  

GO:0016020   membrane  
GO:0005267   potassium channel activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
53 385 4xdk (C) 76 328 27.00 0 0.78 0.264583 1.89
127 205 1orq (C) 165 234 30.00 0.00065 0.14 0.261699 0.67
152 375 3ukm (A) 100 260 41.00 0 0.2 0.0804321 1.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134122)

Species Accession Gene Product
Brugia malayi Bm1_38955   Twik (KCNK-like) family of potassium channels, alpha subunit 28
Caenorhabditis elegans CELE_C52B9.6   Protein TWK-28
Drosophila melanogaster Dmel_CG8713   CG8713 gene product from transcript CG8713-RA
Drosophila melanogaster Dmel_CG34396   CG34396 gene product from transcript CG34396-RC
Echinococcus granulosus EgrG_000885600   potassium channel subfamily K 8
Echinococcus multilocularis EmuJ_000885600   potassium channel subfamily K 8
Homo sapiens ENSG00000186795   potassium channel, subfamily K, member 18
Loa Loa (eye worm) LOAG_02600   TWK-28 protein
Mus musculus ENSMUSG00000040901   potassium channel, subfamily K, member 18
Schistosoma japonicum Sjp_0056180   IPR013099,Ion transport 2,domain-containing
Schistosoma mansoni Smp_141570   twik family of potassium channels-related
Schmidtea mediterranea mk4.032282.00  
Schmidtea mediterranea mk4.000470.04  
Schmidtea mediterranea mk4.003540.01  
Schmidtea mediterranea mk4.009249.00   Twik family of potassium channels-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens potassium channel, subfamily K, member 18 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000885600 (Echinococcus multilocularis), potassium channel subfamily K 8
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