pI: 7.3865 |
Length (AA): 348 |
MW (Da): 38831 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
27 | 347 | 4qrv (A) | 7 | 317 | 41.00 | 0 | 1 | 1.29531 | -0.1 |
32 | 348 | 1cs8 (A) | 1 | 220 | 43.00 | 0 | 1 | 1.38362 | -0.5 |
127 | 347 | 4yyw (A) | 1 | 217 | 44.00 | 0 | 1 | 1.20096 | -1.03 |
128 | 348 | 2p86 (A) | 2 | 214 | 54.00 | 0 | 1 | 1.28096 | -0.73 |
128 | 347 | 8pch (A) | 2 | 210 | 47.00 | 0 | 1 | 1.26008 | -0.85 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131680)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_F54G2.1 | Protein F54G2.1, isoform B |
Drosophila melanogaster | Dmel_CG32381 | CG32381 gene product from transcript CG32381-RC |
Echinococcus granulosus | EgrG_000477200 | cathepsin L |
Echinococcus multilocularis | EmuJ_000477200 | cathepsin L |
Homo sapiens | ENSG00000007516 | BAI1-associated protein 3 |
Homo sapiens | ENSG00000092929 | unc-13 homolog D (C. elegans) |
Mus musculus | ENSMUSG00000047507 | BAI1-associated protein 3 |
Mus musculus | ENSMUSG00000057948 | unc-13 homolog D (C. elegans) |
Schistosoma japonicum | Sjp_0044890 | Cathepsin L1, putative |
Schistosoma japonicum | Sjp_0019430 | BAI1-associated protein 3, putative |
Schistosoma japonicum | Sjp_0019460 | IPR000276,Rhodopsin-like GPCR superfamily;IPR008973,C2 calcium/lipid-binding region, CaLB,domain-containing |
Schistosoma japonicum | Sjp_0132650 | ko:K01365 cathepsin L [EC3.4.22.15], putative |
Schistosoma japonicum | Sjp_0316280 | expressed protein |
Schistosoma japonicum | Sjp_0116670 | Cathepsin L1, putative |
Schistosoma japonicum | Sjp_0203390 | expressed protein |
Schistosoma mansoni | Smp_157090 | subfamily C1A unassigned peptidase (C01 family) |
Schmidtea mediterranea | mk4.016741.00 | Subfamily C1A unassigned peptidase |
Schmidtea mediterranea | mk4.030605.00 | Subfamily C1A unassigned peptidase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Carica papaya | Papain | 345 aa | 36.4% | 352 aa | Compounds | References |
Oryctolagus cuniculus | Cathepsin K | 329 aa | 37.3% | 354 aa | Compounds | References |
Dermatophagoides pteronyssinus | Peptidase 1 | 320 aa | 26.5% | 332 aa | Compounds | References |
Rattus norvegicus | Cathepsin S | 330 aa | 44.7% | 284 aa | Compounds | References |
Capra hircus | Cathepsin H | 335 aa | 41.7% | 300 aa | Compounds | References |
Bos taurus | Cathepsin L | 334 aa | 49.8% | 277 aa | Compounds | References |
Rattus norvegicus | Cathepsin L | 334 aa | 48.2% | 274 aa | Compounds | References |
Rattus norvegicus | Cathepsin K | 329 aa | 38.9% | 334 aa | Compounds | References |