Detailed view for EmuJ_000513400

Basic information

TDR Targets ID: 960885
Echinococcus multilocularis, intersectin 2
Source Database / ID:  GeneDB

pI: 6.5884 | Length (AA): 1640 | MW (Da): 182600 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF00168   C2 domain
PF00621   RhoGEF domain
PF12763   Cytoskeletal-regulatory complex EF hand
PF14604   Variant SH3 domain
PF16652   Pleckstrin homology domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005509   calcium ion binding  
GO:0005089   Rho guanyl-nucleotide exchange factor activity  
GO:0035023   regulation of Rho protein signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 15 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 105 2qpt (A) 419 534 44.00 0.0000000000066 1 0.629824 -1.2
2 100 2kff (A) 39 136 47.00 0 1 0.771166 -1.65
5 98 2khn (A) 23 116 57.00 0 1 0.878117 -1.65
128 224 2kgr (A) 2 98 46.00 0 1 0.662146 -1.6
184 541 5ghe (A) 30 385 12.00 0 0.11 0.131293 -0.19
263 493 5cwp (A) 5 223 11.00 0 0.05 0.206854 -1.23
265 341 4o9b (A) 250 323 19.00 0 0.01 0.267951 -1.88
271 499 5j1i (A) 1017 1290 31.00 0.24 0.99 0.310434 -0.26
280 399 2l3l (A) 27 126 39.00 0.65 0.25 0.233971 0.2
703 748 2fpe (A) 6 52 39.00 0.34 0.55 0.421849 0.17
830 878 2kbt (A) 793 837 49.00 0.0035 0.87 0.488678 -0.26
1053 1391 1rj2 (G) 631 930 20.00 0 1 0.0457073 0.74
1055 1237 3gf9 (A) 1182 1366 37.00 0 1 0.705385 -1.78
1504 1628 3jzy (A) 1542 1660 32.00 0 0.97 0.40122 -0.75
1505 1596 2nq3 (A) 20 107 34.00 0.4 0.59 0.391898 -0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130570)

Species Accession Gene Product
Brugia malayi Bm1_02740   hypothetical protein
Brugia malayi Bm1_02735   Variant SH3 domain containing protein
Caenorhabditis elegans CELE_Y116A8C.36   Protein ITSN-1, isoform C
Drosophila melanogaster Dmel_CG1099   Dynamin associated protein 160
Echinococcus granulosus EgrG_000513400   intersectin 2
Echinococcus multilocularis EmuJ_000007500   dynamin associated protein
Echinococcus multilocularis EmuJ_000513400   intersectin 2
Homo sapiens ENSG00000205726   intersectin 1 (SH3 domain protein)
Homo sapiens ENSG00000198399   intersectin 2
Loa Loa (eye worm) LOAG_06192   hypothetical protein
Loa Loa (eye worm) LOAG_06191   hypothetical protein
Loa Loa (eye worm) LOAG_13437   hypothetical protein
Mus musculus ENSMUSG00000022957   intersectin 1 (SH3 domain protein 1A)
Mus musculus ENSMUSG00000020640   intersectin 2
Onchocerca volvulus OVOC4084  
Schistosoma japonicum Sjp_0124170   Intersectin-1, putative
Schistosoma japonicum Sjp_0037040   Intersectin-1, putative
Schistosoma mansoni Smp_135790   dynamin-associated protein
Schmidtea mediterranea mk4.016198.03  
Schmidtea mediterranea mk4.002446.04  
Schmidtea mediterranea mk4.006714.00  
Schmidtea mediterranea mk4.009085.00  
Schmidtea mediterranea mk4.000534.02  
Schmidtea mediterranea mk4.005570.00  
Schmidtea mediterranea mk4.003200.00  
Schmidtea mediterranea mk4.028620.01  
Schmidtea mediterranea mk4.022872.01  
Schmidtea mediterranea mk4.006003.00  
Schmidtea mediterranea mk4.002296.04  
Schmidtea mediterranea mk4.028620.00  
Schmidtea mediterranea mk4.010573.00  
Schmidtea mediterranea mk4.003200.01  
Schmidtea mediterranea mk4.026915.01  
Schmidtea mediterranea mk4.016198.04  
Schmidtea mediterranea mk4.003200.05  
Schmidtea mediterranea mk4.000703.01  
Schmidtea mediterranea mk4.010573.01  
Schmidtea mediterranea mk4.003200.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0378 0.315 0.315
0.0057 0.3491 0.3491
0.0282 0.283 0.283
0.0048 0.281 0.281
0.0107 0.5 0.5
0.0065 0.3464 0.3464
0.0109 0.4866 0.4866
0.0048 0.3625 0.3565
0.0072 0.2639 0.2639
0.0137 0.3036 0.3036
0.0018 0.5 0.5
0.0065 0.3464 0.3464
0.0053 0.2787 0.2787
0.0029 0.4037 0.4037
0.0137 0.2846 0.2741
0.0059 0.3 0.3006
0.00394418 0.278418 0.262031
0.0121 1 1
0.0075 0.2576 0.2135
0.0029 0.4037 0.4037
0.0351989 0.270507 0.26116
0.0058 0.5 0.5
0.0126 0.2517 0.2517
0.0113 0.2515 0.2515
0.0068 0.2794 0.2794
0.0061 1 1
0.0282 0.283 0.283
0.0027 0.3179 0.2899
0.00394418 0.278418 0.262031
0.0064 0.3347 0.3362
0.0336199 0.276589 0.265254
0.0322685 0.273741 0.262341
0.0118 0.2522 0.2522
0.0039 0.2713 0.0459
0.0125 0.3893 0.9758
0.0039 0.2713 0.0459
0.0027 0.3179 0.2899
0.0071 0.2549 0.2498

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000513400 (Echinococcus multilocularis), intersectin 2
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