Detailed view for EmuJ_000616700

Basic information

TDR Targets ID: 961866
Echinococcus multilocularis, metallo beta lactamase domain containing protein
Source Database / ID:  GeneDB

pI: 5.1976 | Length (AA): 196 | MW (Da): 21738 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00753   Metallo-beta-lactamase superfamily

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 196 4v0h (A) 21 240 40.00 0 1 1.5238 -1.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132377)

Species Accession Gene Product
Brugia malayi Bm1_09835   hypothetical protein
Brugia malayi Bm1_01940   metallo-beta-lactamase superfamily protein
Caenorhabditis elegans CELE_F53B1.6   Protein F53B1.6
Caenorhabditis elegans CELE_B0432.9   Protein B0432.9
Drosophila melanogaster Dmel_CG9117   CG9117 gene product from transcript CG9117-RA
Echinococcus granulosus EgrG_000616700   metallo beta lactamase domain containing protein
Echinococcus multilocularis EmuJ_000616700   metallo beta lactamase domain containing protein
Homo sapiens ENSG00000214309   metallo-beta-lactamase domain containing 1
Loa Loa (eye worm) LOAG_07501   hypothetical protein
Loa Loa (eye worm) LOAG_12920   metallo-beta-lactamase superfamily protein
Mus musculus ENSMUSG00000049285   metallo-beta-lactamase domain containing 1
Mycobacterium tuberculosis Rv1913   Conserved hypothetical protein
Onchocerca volvulus OVOC3197  
Onchocerca volvulus OVOC2590  
Schistosoma japonicum Sjp_0014920   Beta-lactamase-like protein LOC255374 homolog, putative
Schistosoma mansoni Smp_043930   hypothetical protein
Schmidtea mediterranea mk4.018452.00  
Schmidtea mediterranea mk4.003521.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0141 0.5 0.5
0.0068 0.616 1
0.0139 0.3313 0.3248
0.0173 0.5058 0.505
0.0098 0.5 0.5
0.0019 0.5 0.5
0.0151 0.5 0.5
0.0161 1 1
0.0333 0.487 0.4866
0.0051 0.5023 0.5
0.0284 0.6112 0.6088
0.0153 1 1
0.0079 0.301 1
0.0208 0.4509 0.5756
0.0101 0.5 0.5
0.0183 1 1
0.0215 0.5175 0.5
0.0304 0.3722 0.3722
0.0307 0.4131 0.4131
0.0304 0.3722 0.3722
0.03 0.9089 0.908
0.0224 1 1
0.0263 0.5703 0.7744
0.0033 0.5 0.5
0.0286 1 1
0.024 0.347 0.347
0.0138 0.8072 0.8072
0.035 0.2506 0.2506
0.0404 0.2792 0.2792
0.0156 1 1
0.0367 0.531 0.531
0.0115 1 1
0.03 0.9089 0.908
0.0085 0.271 0.2164
0.0249 0.3365 0.3357
0.0031 0.5 0.5
0.0101 0.5 0.5
0.0065 0.5 0.5
0.0088 0.4106 0.313
0.0282 0.3876 0.3838
0.032 0.4025 0.3998
0.0134 0.3422 0.3422
0.0153 1 1
0.0259 0.336 0.3327

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000616700 (Echinococcus multilocularis), metallo beta lactamase domain containing protein
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