Detailed view for EmuJ_000078300

Basic information

TDR Targets ID: 962173
Echinococcus multilocularis, RNA directed DNA polymerase (reverse transcriptase)
Source Database / ID:  GeneDB

pI: 10.4471 | Length (AA): 271 | MW (Da): 30923 | Paralog Number: 17

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00078   Reverse transcriptase (RNA-dependent DNA polymerase)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 253 4mh8 (A) 188 438 27.00 0 1 1.26138 -0.06
1 269 4ol8 (B) 183 443 36.00 0 1 1.35742 0.37
37 135 2czq (A) 47 120 39.00 0.39 0.17 0.351114 0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126567)

Species Accession Gene Product
Arabidopsis thaliana ArthMp074   hypothetical protein
Arabidopsis thaliana ArthMp075   hypothetical protein
Arabidopsis thaliana AT4G13320   hypothetical protein
Candida albicans CaO19.14099   similar to reverse transcripases
Candida albicans CaO19.2164   polyprotein of gypsy-like retrotransposon Tca3
Candida albicans CaO19.2219   polyprotein of gypsy-like retrotransposon Tca3
Candida albicans CaO19.12173   Potential retroviral integrase
Candida albicans CaO19.9710   polyprotein of gypsy-like retrotransposon Tca3
Candida albicans CaO19.6807   similar to reverse transcripases
Candida albicans CaO19.9764   polyprotein of gypsy-like retrotransposon Tca3
Caenorhabditis elegans CELE_F40F12.9   Protein F40F12.9, isoform B
Dictyostelium discoideum DDB_G0294254   hypothetical protein
Dictyostelium discoideum DDB_G0294256   hypothetical protein
Dictyostelium discoideum DDB_G0281535   hypothetical protein
Dictyostelium discoideum DDB_G0270954   hypothetical protein
Dictyostelium discoideum DDB_G0294360   hypothetical protein
Dictyostelium discoideum DDB_G0294164   hypothetical protein
Dictyostelium discoideum DDB_G0267362   hypothetical protein
Dictyostelium discoideum DDB_G0267306   hypothetical protein
Dictyostelium discoideum DDB_G0267366   hypothetical protein
Dictyostelium discoideum DDB_G0294320   hypothetical protein
Dictyostelium discoideum DDB_G0267356   hypothetical protein
Dictyostelium discoideum DDB_G0294228   hypothetical protein
Dictyostelium discoideum DDB_G0294338   hypothetical protein
Dictyostelium discoideum DDB_G0294358   hypothetical protein
Dictyostelium discoideum DDB_G0294322   hypothetical protein
Echinococcus granulosus EgrG_000332600   RNA directed DNA polymerase reverse transcriptase
Echinococcus granulosus EgrG_002036400   retrotransposable element Tf2 155 kDa protein
Echinococcus granulosus EgrG_000519700   KRAB A domain containing protein
Echinococcus granulosus EgrG_000078300   RNA directed DNA polymerase reverse transcriptase
Echinococcus granulosus EgrG_000864400   RNA directed DNA polymerase reverse transcriptase
Echinococcus granulosus EgrG_000276900   KRAB A domain containing protein
Echinococcus granulosus EgrG_002029200   KRAB A domain containing protein
Echinococcus granulosus EgrG_002065700   KRAB A domain containing protein
Echinococcus granulosus EgrG_002017100   RNA directed DNA polymerase reverse transcriptase
Echinococcus multilocularis EmuJ_000696200   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_001177800   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000835700   KRAB-A domain-containing protein
Echinococcus multilocularis EmuJ_000971200   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000519700   KRAB A domain containing protein
Echinococcus multilocularis EmuJ_000696300   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000344300   KRAB A domain containing protein
Echinococcus multilocularis EmuJ_000420600   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000798400   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000971300   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000078300   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_001192700   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000405900   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_001192800   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000421100   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000332600   RNA directed DNA polymerase (reverse transcriptase)
Echinococcus multilocularis EmuJ_000806700   KRAB A domain containing protein
Echinococcus multilocularis EmuJ_000201800   RNA directed DNA polymerase (reverse transcriptase)
Leishmania braziliensis LbrM.29.2060   hypothetical protein
Oryza sativa 4335122   Os04g0191000
Oryza sativa 4346512   Os09g0250500
Oryza sativa 4351358   Os12g0121200
Oryza sativa 4326584   Os01g0640000
Oryza sativa 4338193   Os05g0241900
Oryza sativa 4341086   Os06g0493000
Oryza sativa 4352106   Os12g0428300
Oryza sativa 4332571   Os03g0300700
Oryza sativa 9268490   Os10g0383200
Oryza sativa 4350106   Os11g0224300
Oryza sativa 4343440   Os07g0528900
Oryza sativa 9269336   Os09g0321300
Oryza sativa 4335669   Os04g0389000
Oryza sativa 4340711   Os06g0266100
Oryza sativa 4346466   Os09g0135100
Oryza sativa 9272273   Os08g0123950
Oryza sativa 4329502   Os02g0522000
Oryza sativa 9268521   Os07g0148400
Oryza sativa 4350342   Os11g0305400
Oryza sativa 4332963   Os03g0377400
Oryza sativa 4333099   Os03g0411900
Oryza sativa 4343355   Os07g0510800
Oryza sativa 4342054   Os06g0713500
Oryza sativa 4345730   Os08g0451600
Oryza sativa 4335375   Os04g0283700
Oryza sativa 4336900   Os04g0603800
Oryza sativa 4347442   Os09g0491900
Oryza sativa 4344745   Os08g0164800
Oryza sativa 9269300   Os12g0194000
Oryza sativa 4345263   Os08g0321500
Oryza sativa 9271085   Os10g0322250
Oryza sativa 9269157   Os05g0263200
Oryza sativa 4348294   Os10g0317000
Oryza sativa 4331616   Os03g0147100
Oryza sativa 9266908   Os12g0142900
Oryza sativa 4337440   Os04g0682600
Saccharomyces cerevisiae YGR109W-B   gag-pol fusion protein
Saccharomyces cerevisiae YGR109W-A   gag protein
Saccharomyces cerevisiae YIL082W-A   gag-pol fusion protein
Schistosoma japonicum Sjp_0081750   Transposon Ty3-I Gag-Pol polyprotein, putative
Schistosoma japonicum Sjp_0118750   Transposon Ty3-G Gag-Pol polyprotein, putative
Schistosoma japonicum Sjp_0051360   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0082490   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0017040   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0115710   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0019320   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0034220   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0066450   Conserved hypothetical protein
Schistosoma japonicum Sjp_0095510   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0028150   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0219410   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0219330   IPR001584,Integrase, catalytic region,domain-containing
Schistosoma japonicum Sjp_0044570   Conserved hypothetical protein
Schistosoma japonicum Sjp_0088880   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0116760   Conserved hypothetical protein
Schistosoma japonicum Sjp_0056250   IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0117980   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0102730   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0105820   IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0113030   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0308780   IPR012337,Polynucleotidyl transferase, Ribonuclease H fold;IPR001584,Integrase, catalytic core,domain-containing
Schistosoma japonicum Sjp_0005040   IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0087230   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0099320   similar to Retrotransposable element Tf2 155 kDa protein type 2, putative
Schistosoma japonicum Sjp_0065290   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0112640   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0083180   Transposon Ty3-I Gag-Pol polyprotein, putative
Schistosoma japonicum Sjp_0071250   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0112290   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0121280   IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing
Schistosoma japonicum Sjp_0125250   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0019980   IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0102620   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0128310   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0120660   IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0118760   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0208350   Transposon Ty3-G Gag-Pol polyprotein, putative
Schistosoma japonicum Sjp_0059110   Conserved hypothetical protein
Schistosoma japonicum Sjp_0125080   Transposon Ty3-I Gag-Pol polyprotein, putative
Schistosoma japonicum Sjp_0219690   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0112630   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0122430   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0126520   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0124770   Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease, putative
Schistosoma japonicum Sjp_0013710   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0080080   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0120220   similar to Retrotransposable element Tf2 155 kDa protein type 2, putative
Schistosoma japonicum Sjp_0079340   Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease, putative
Schistosoma japonicum Sjp_0092130   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0132220   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0001020   Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease, putative
Schistosoma japonicum Sjp_0091430   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0062130   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0117280   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0109720   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0051370   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0105160   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0126620   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0009480   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0093220   hypothetical protein
Schistosoma japonicum Sjp_0044240   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0029130   hypothetical protein
Schistosoma japonicum Sjp_0069240   IPR001995,Peptidase A2A, retrovirus, catalytic;IPR001969,Peptidase aspartic, active site;IPR009007,Peptidase aspartic, catalytic
Schistosoma japonicum Sjp_0097440   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0109440   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0064230   Conserved hypothetical protein
Schistosoma japonicum Sjp_0112140   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0064830   Transposon Ty3-I Gag-Pol polyprotein, putative
Schistosoma japonicum Sjp_0035250   Conserved hypothetical protein
Schistosoma japonicum Sjp_0062150   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0118740   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0012080   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0119800   similar to Uncharacterized protein F44E2.2, putative
Schistosoma japonicum Sjp_0112040   Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease, putative
Schistosoma japonicum Sjp_0123880   similar to Uncharacterized protein F44E2.2, putative
Schistosoma mansoni Smp_168700   hypothetical protein
Schmidtea mediterranea mk4.019373.00  
Schmidtea mediterranea mk4.031486.00  
Schmidtea mediterranea mk4.029692.00  
Schmidtea mediterranea mk4.000995.01  
Schmidtea mediterranea mk4.015913.02  
Schmidtea mediterranea mk4.002198.04  
Schmidtea mediterranea mk4.027279.00  
Schmidtea mediterranea mk4.002407.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000078300 (Echinococcus multilocularis), RNA directed DNA polymerase (reverse transcriptase)
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