pI: 7.4916 |
Length (AA): 878 |
MW (Da): 97619 |
Paralog Number:
6
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
153 | 872 | 1z3i (X) | 126 | 728 | 36.00 | 0 | 1 | 0.998846 | 0.47 |
154 | 809 | 1z3i (X) | 127 | 696 | 41.00 | 0 | 1 | 1.03835 | 0.11 |
232 | 366 | 1fuu (A) | 68 | 206 | 13.00 | 0 | 0.82 | 0.431559 | -1.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127098)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G19210 | Rad54-like protein |
Babesia bovis | BBOV_IV009640 | DNA repair and recombination protein RAD54-like, putative |
Brugia malayi | Bm1_13120 | Type III restriction enzyme, res subunit family protein |
Brugia malayi | Bm1_19500 | recombination factor GdRad54 |
Candida albicans | CaO19.5004 | similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination |
Candida albicans | CaO19.12827 | Putative helicase similar to RAD54 |
Candida albicans | CaO19.5367 | Putative helicase similar to RAD54 |
Candida albicans | CaO19.12471 | similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination |
Caenorhabditis elegans | CELE_Y116A8C.13 | Protein Y116A8C.13, isoform B |
Caenorhabditis elegans | CELE_W06D4.6 | Protein RAD-54 |
Cryptosporidium hominis | Chro.10140 | DNA repair protein RAD54-like |
Cryptosporidium parvum | cgd1_1180 | RAD54 like SWI/SNF2 ATpase |
Dictyostelium discoideum | DDB_G0285117 | CHR group protein |
Dictyostelium discoideum | DDB_G0282997 | CHR group protein |
Drosophila melanogaster | Dmel_CG3736 | okra |
Echinococcus granulosus | EgrG_000609300 | SPRY domain containing protein |
Echinococcus granulosus | EgrG_000446700 | SPRY domain containing protein |
Echinococcus granulosus | EgrG_000375000 | dna repair and recombination protein rad54 |
Echinococcus granulosus | EgrG_000303900 | DNA repair and recombination protein RAD54B |
Echinococcus granulosus | EgrG_000093900 | SPRY domain containing protein |
Entamoeba histolytica | EHI_114930 | DNA repair protein, putative |
Entamoeba histolytica | EHI_103840 | DNA repair protein, putative |
Echinococcus multilocularis | EmuJ_000446700 | SPRY domain containing protein |
Echinococcus multilocularis | EmuJ_000335300 | dna repair and recombination protein rad54 |
Echinococcus multilocularis | EmuJ_000303900 | |
Echinococcus multilocularis | EmuJ_000375000 | dna repair and recombination protein rad54 |
Echinococcus multilocularis | EmuJ_000609300 | |
Echinococcus multilocularis | EmuJ_000336000 | dna repair and recombination protein rad54 |
Echinococcus multilocularis | EmuJ_000093900 | SPRY domain containing protein |
Homo sapiens | ENSG00000197275 | RAD54 homolog B (S. cerevisiae) |
Homo sapiens | ENSG00000085999 | RAD54-like (S. cerevisiae) |
Leishmania braziliensis | LbrM.24.0770 | DNA repair and recombination protein RAD54, putative |
Leishmania donovani | LdBPK_240770.1 | DNA repair and recombination protein RAD54, putative |
Leishmania infantum | LinJ.24.0770 | DNA repair and recombination protein RAD54, putative |
Leishmania major | LmjF.24.0760 | DNA repair and recombination protein RAD54, putative |
Leishmania mexicana | LmxM.24.0760 | DNA repair and recombination protein RAD54, putative |
Loa Loa (eye worm) | LOAG_08903 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09350 | type III restriction enzyme |
Loa Loa (eye worm) | LOAG_09349 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02898 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09351 | hypothetical protein |
Mus musculus | ENSMUSG00000028702 | RAD54 like (S. cerevisiae) |
Mus musculus | ENSMUSG00000078773 | RAD54 homolog B (S. cerevisiae) |
Neospora caninum | NCLIV_032440 | hypothetical protein |
Oryza sativa | 4330819 | Os02g0762800 |
Plasmodium berghei | PBANKA_1226800 | DNA repair and recombination protein RAD54, putative |
Plasmodium falciparum | PF3D7_0803400 | DNA repair and recombination protein RAD54, putative |
Plasmodium knowlesi | PKNH_0115500 | DNA repair and recombination protein RAD54, putative |
Plasmodium vivax | PVX_093575 | DNA repair protein RAD54, putative |
Plasmodium yoelii | PY00810 | DNA repair protein RAD54-like-related |
Saccharomyces cerevisiae | YGL163C | DNA-dependent ATPase RAD54 |
Saccharomyces cerevisiae | YBR073W | DNA-dependent ATPase RDH54 |
Schistosoma japonicum | Sjp_0119580 | DNA repair and recombination protein RAD54-like, putative |
Schistosoma japonicum | Sjp_0079550 | DNA repair and recombination protein RAD54B, putative |
Schistosoma japonicum | Sjp_0031520 | IPR000299,Band 4.1,domain-containing |
Schistosoma japonicum | Sjp_0031540 | ko:K01529 RAD54L, GdRAD54; RAD54-like [EC:3.6.1.-], putative |
Schistosoma japonicum | Sjp_0080310 | ATP-dependent RNA helicase DDX1, putative |
Schistosoma mansoni | Smp_194820 | DNA repair and recombination protein rad54-related |
Schistosoma mansoni | Smp_026030 | DNA repair and recombination protein rad54-related |
Schmidtea mediterranea | mk4.004644.01 | DNA repair and recombination protein RAD54-like |
Schmidtea mediterranea | mk4.011618.00 | Putative 4.1 G protein |
Schmidtea mediterranea | mk4.001926.03 | |
Schmidtea mediterranea | mk4.004146.02 | Putative 4.1 G protein |
Schmidtea mediterranea | mk4.031513.01 | |
Trypanosoma brucei gambiense | Tbg972.11.6120 | DNA repair and recombination protein RAD54, putative |
Trypanosoma brucei | Tb927.11.5430 | DNA repair and recombination protein RAD54, putative |
Trypanosoma congolense | TcIL3000.11.5670 | DNA repair and recombination protein RAD54, putative |
Trypanosoma cruzi | TcCLB.505183.40 | DNA repair and recombination protein RAD54, putative |
Trypanosoma cruzi | TcCLB.508647.290 | DNA repair and recombination protein RAD54, putative |
Theileria parva | TP01_0805 | DNA repair protein rad54, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3110 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3110 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3110 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb11.02.3110 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y116A8C.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_1226800 | Plasmodium berghei | Slow | plasmo |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | RAD54-like (S. cerevisiae) | Compounds | References |