pI: 8.6686 |
Length (AA): 386 |
MW (Da): 42010 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
25 | 384 | 5h2z (A) | 32 | 385 | 46.00 | 0 | 1 | 1.51566 | -1.02 |
30 | 384 | 4ori (A) | 37 | 385 | 49.00 | 0 | 1 | 1.53778 | -1.1 |
71 | 375 | 4xq6 (A) | 47 | 338 | 44.00 | 0 | 1 | 1.36891 | -1.51 |
305 | 372 | 1h5y (A) | 61 | 122 | 39.00 | 0.49 | 0.72 | 0.560323 | -0.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127289)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G23300 | dihydroorotate dehydrogenase |
Babesia bovis | BBOV_II007190 | dihydroorotate dehydrogenase |
Brugia malayi | Bm1_50015 | Dihydroorotate dehydrogenase, mitochondrial precursor, putative |
Brugia malayi | Bm1_56440 | Dihydroorotate dehydrogenase, mitochondrial precursor, putative |
Candida albicans | CaO19.12299 | likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin |
Candida albicans | CaO19.4836 | likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin |
Caenorhabditis elegans | CELE_W02D3.2 | Protein DHOD-1 |
Drosophila melanogaster | Dmel_CG9741 | Dihydroorotate dehydrogenase |
Escherichia coli | b0945 | dihydro-orotate oxidase, FMN-linked |
Homo sapiens | ENSG00000102967 | dihydroorotate dehydrogenase (quinone) |
Leishmania braziliensis | LbrM.16.0550 | dihydroorotate dehydrogenase |
Leishmania donovani | LdBPK_160540.1 | dihydroorotate dehydrogenase |
Leishmania infantum | LinJ.16.0540 | dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530 |
Leishmania major | LmjF.16.0530 | dihydroorotate dehydrogenase |
Leishmania mexicana | LmxM.16.0530 | dihydroorotate dehydrogenase, putative |
Mycobacterium leprae | ML1293c | Probable dihydroorotate dehydrogenase PyrD |
Mus musculus | ENSMUSG00000031730 | dihydroorotate dehydrogenase |
Mycobacterium tuberculosis | Rv2139 | Probable dihydroorotate dehydrogenase PyrD |
Mycobacterium ulcerans | MUL_2370 | dihydroorotate dehydrogenase 2 |
Neospora caninum | NCLIV_012040 | dihydroorotate dehydrogenase, putative |
Oryza sativa | 4337396 | Os04g0676300 |
Plasmodium berghei | PBANKA_0102100 | dihydroorotate dehydrogenase, putative |
Plasmodium falciparum | PF3D7_0603300 | dihydroorotate dehydrogenase |
Plasmodium knowlesi | PKNH_1147400 | dihydroorotate dehydrogenase, putative |
Plasmodium vivax | PVX_113330 | dihydroorotate dehydrogenase, mitochondrial precursor, putative |
Plasmodium yoelii | PY02580 | dihydroorotate dehydrogenase, putative |
Saccharomyces cerevisiae | YKL216W | dihydroorotate dehydrogenase |
Schistosoma japonicum | Sjp_0002940 | ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative |
Schistosoma mansoni | Smp_078730 | dihydroorotate dehydrogenase |
Schmidtea mediterranea | mk4.000860.06 | Dihydroorotate dehydrogenase |
Schmidtea mediterranea | mk4.028649.02 | |
Trypanosoma brucei gambiense | Tbg972.5.5320 | dihydroorotate dehydrogenase, putative |
Trypanosoma brucei | Tb927.5.3830 | dihydroorotate dehydrogenase (fumarate) |
Trypanosoma congolense | TcIL3000_5_4300 | dihydroorotate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.511643.20 | dihydroorotate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.507091.40 | dihydroorotate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.508375.50 | dihydroorotate dehydrogenase (fumarate), putative |
Toxoplasma gondii | TGME49_210790 | dihydroorotate dehydrogenase reveal, putative |
Theileria parva | TP02_0171 | dihydroorotate dehydrogenase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0098 | dihydroorotate dehydrogenase 2 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2172 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.5.3830 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3830 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.3830 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0945 | Escherichia coli | non-essential | goodall |
PBANKA_0102100 | Plasmodium berghei | Slow | plasmo |
TGME49_210790 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | Compounds | References |
Plasmodium falciparum | dihydroorotate dehydrogenase | Compounds | References |
Homo sapiens | dihydroorotate dehydrogenase (quinone) | Compounds | References |
Mus musculus | dihydroorotate dehydrogenase | Compounds | References |
Saccharomyces cerevisiae | dihydroorotate dehydrogenase | Compounds | References |
Rattus norvegicus | Dihydroorotate dehydrogenase | Compounds | References |
Plasmodium berghei | dihydroorotate dehydrogenase, putative | Compounds | References |