Detailed view for Sjp_0105630

Basic information

TDR Targets ID: 968441
Schistosoma japonicum, Conserved hypothetical protein
Source Database / ID:  Wormbase Parasite  

pI: 8.8159 | Length (AA): 182 | MW (Da): 21370 | Paralog Number: 4

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128363)

Species Accession Gene Product
Arabidopsis thaliana AT3G16785   phospholipase D P1
Arabidopsis thaliana AT3G05630   phospholipase D P2
Brugia malayi Bm1_08640   Phospholipase d protein 1
Candida albicans CaO19.8753   Phospholipase D:required for commitment to meiosis
Candida albicans CaO19.1161   Phospholipase D:required for commitment to meiosis
Caenorhabditis elegans CELE_C04G6.3   Protein PLD-1
Dictyostelium discoideum DDB_G0279483   phospholipase D1
Dictyostelium discoideum DDB_G0277949   phospholipase D1
Dictyostelium discoideum DDB_G0281031   phospholipase D1
Drosophila melanogaster Dmel_CG12110   Phospholipase D
Echinococcus granulosus EgrG_000249000   phospholipase D
Echinococcus granulosus EgrG_000249100   phospholipase D1
Entamoeba histolytica EHI_146550   phospholipase D, putative
Entamoeba histolytica EHI_146400   phospholipase D active site domain-containing protein
Entamoeba histolytica EHI_082560   phospholipase D, putative
Echinococcus multilocularis EmuJ_000249000   phospholipase D
Echinococcus multilocularis EmuJ_000249100   phospholipase D1
Homo sapiens ENSG00000075651   phospholipase D1, phosphatidylcholine-specific
Homo sapiens ENSG00000129219   phospholipase D2
Loa Loa (eye worm) LOAG_11567   hypothetical protein
Loa Loa (eye worm) LOAG_11069   hypothetical protein
Loa Loa (eye worm) LOAG_14481   hypothetical protein
Loa Loa (eye worm) LOAG_13909   hypothetical protein
Mus musculus ENSMUSG00000027695   phospholipase D1
Mus musculus ENSMUSG00000020828   phospholipase D2
Oryza sativa 4338532   Os05g0358700
Oryza sativa 9272440   Os01g0310100
Saccharomyces cerevisiae YKR031C   phospholipase D
Schistosoma japonicum Sjp_0081710   ko:K01115 phospholipase D [EC3.1.4.4], putative
Schistosoma japonicum Sjp_0079810   expressed protein
Schistosoma japonicum Sjp_0075670   ko:K01115 phospholipase D [EC3.1.4.4], putative
Schistosoma japonicum Sjp_0105630   Conserved hypothetical protein
Schistosoma japonicum Sjp_0079820   Phospholipase D1, putative
Schistosoma mansoni Smp_151420   phospholipase D
Schmidtea mediterranea mk4.001699.02   Phospholipase D
Schmidtea mediterranea mk4.001699.04   Phospholipase D
Schmidtea mediterranea mk4.001699.03   Phospholipase D
Schmidtea mediterranea mk4.001699.01  

Essentiality

Sjp_0105630 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C04G6.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phospholipase D1, phosphatidylcholine-specific Compounds References
Homo sapiens phospholipase D2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0105630 (Schistosoma japonicum), Conserved hypothetical protein
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