Detailed view for Sjp_0302810

Basic information

TDR Targets ID: 971132
Schistosoma japonicum, ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative
Source Database / ID:  Wormbase Parasite  

pI: 7.911 | Length (AA): 380 | MW (Da): 44205 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00503   G-protein alpha subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0031683   G-protein beta/gamma-subunit binding  
GO:0019001   guanyl nucleotide binding  
GO:0005525   GTP binding  
GO:0003924   GTPase activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  
GO:0007165   signal transduction  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131088)

Species Accession Gene Product
Brugia malayi Bm1_48675   GTP-binding regulatory protein Gs alpha-S chain, putative
Caenorhabditis elegans CELE_R06A10.2   Protein GSA-1
Drosophila melanogaster Dmel_CG2835   G protein alpha s subunit
Echinococcus granulosus EgrG_000677700   guanine nucleotide binding protein Gs subunit
Echinococcus granulosus EgrG_000149800   guanine nucleotide binding protein Gs subunit
Echinococcus multilocularis EmuJ_000677700   guanine nucleotide binding protein G(s) subunit
Echinococcus multilocularis EmuJ_000149800   guanine nucleotide binding protein G(s) subunit
Homo sapiens ENSG00000087460   GNAS complex locus
Homo sapiens ENSG00000141404   guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
Loa Loa (eye worm) LOAG_05696   GTP-binding regulatory protein Gs alpha-S chain
Mus musculus ENSMUSG00000024524   guanine nucleotide binding protein, alpha stimulating, olfactory type
Mus musculus ENSMUSG00000027523   GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Schistosoma japonicum Sjp_0302810   ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative
Schistosoma mansoni Smp_059340.3   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)
Schistosoma mansoni Smp_059340.1   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)
Schistosoma mansoni Smp_059340.2   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)
Schmidtea mediterranea mk4.001118.01   Protein ALEX
Schmidtea mediterranea mk4.000734.12   Protein ALEX
Schmidtea mediterranea mk4.000136.06   Protein ALEX
Schmidtea mediterranea mk4.001118.00   Guanine nucleotide-binding protein G(olf) subunit alpha
Schmidtea mediterranea mk4.003459.03  
Schmidtea mediterranea mk4.000136.15   Protein ALEX
Schmidtea mediterranea mk4.000986.00   Protein ALEX
Schmidtea mediterranea mk4.000734.13   Protein ALEX
Schmidtea mediterranea mk4.000734.05   Protein ALEX
Schmidtea mediterranea mk4.003459.04   Protein ALEX
Schmidtea mediterranea mk4.000026.09   Guanine nucleotide-binding protein G(olf) subunit alpha
Schmidtea mediterranea mk4.000734.04   Protein ALEX
Schmidtea mediterranea mk4.000026.08   Guanine nucleotide-binding protein G(olf) subunit alpha
Schmidtea mediterranea mk4.000734.06  

Essentiality

Sjp_0302810 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R06A10.2 Caenorhabditis elegans larval lethal wormbase
CELE_R06A10.2 Caenorhabditis elegans slow growth wormbase
CELE_R06A10.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens GNAS complex locus Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0302810 (Schistosoma japonicum), ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative
Title for this comment
Comment