Detailed view for Sjp_0085230

Basic information

TDR Targets ID: 972028
Schistosoma japonicum, IPR008758,Peptidase S28,domain-containing
Source Database / ID:  Wormbase Parasite  

pI: 7.9199 | Length (AA): 116 | MW (Da): 13515 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05577   Serine carboxypeptidase S28

Gene Ontology

Mouse over links to read term descriptions.
GO:0008236   serine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 92 5z42 (A) 6 71 30.00 0.15 0.81 1.03881 -0.92
28 92 4r62 (A) 84 142 39.00 0.7 0.36 0.855417 0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130246)

Species Accession Gene Product
Arabidopsis thaliana AT2G24280   alpha/beta-Hydrolases superfamily protein
Arabidopsis thaliana AT5G65760   Serine carboxypeptidase S28 family protein
Brugia malayi Bm1_07010   Serine carboxypeptidase S28 family protein
Caenorhabditis elegans CELE_ZK688.6   Protein PCP-5, isoform A
Caenorhabditis elegans CELE_ZK112.1   Protein PCP-1
Dictyostelium discoideum DDB_G0289749   peptidase S28 family protein
Dictyostelium discoideum DDB_G0289231   peptidase S28 family protein
Drosophila melanogaster Dmel_CG2493   CG2493 gene product from transcript CG2493-RA
Echinococcus granulosus EgrG_001028800   Lysosomal Pro X carboxypeptidase
Echinococcus multilocularis EmuJ_001028800   Lysosomal Pro X carboxypeptidase
Homo sapiens ENSG00000137509   prolylcarboxypeptidase (angiotensinase C)
Loa Loa (eye worm) LOAG_10893   hypothetical protein
Loa Loa (eye worm) LOAG_06857   hypothetical protein
Loa Loa (eye worm) LOAG_06858   hypothetical protein
Mus musculus ENSMUSG00000061119   prolylcarboxypeptidase (angiotensinase C)
Oryza sativa 4325498   Os01g0767100
Oryza sativa 4341667   Os06g0647400
Oryza sativa 4349822   Os11g0156200
Schistosoma japonicum Sjp_0317470   IPR008758,Peptidase S28,domain-containing
Schistosoma japonicum Sjp_0085250   ko:K01285 lysosomal Pro-X carboxypeptidase [EC3.4.16.2], putative
Schistosoma japonicum Sjp_0085230   IPR008758,Peptidase S28,domain-containing
Schistosoma mansoni Smp_002600.2   lysosomal Pro-Xaa carboxypeptidase (S28 family)
Schmidtea mediterranea mk4.007512.04   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.009784.00   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.004887.05   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.018515.02   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.005054.02   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.016295.02   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.004887.06   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.022921.00   Lysosomal Pro-X carboxypeptidase
Schmidtea mediterranea mk4.019222.00   Lysosomal Pro-X carboxypeptidase

Essentiality

Sjp_0085230 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK688.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus prolylcarboxypeptidase (angiotensinase C) Compounds References
Homo sapiens prolylcarboxypeptidase (angiotensinase C) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0085230 (Schistosoma japonicum), IPR008758,Peptidase S28,domain-containing
Title for this comment
Comment