Detailed view for Sjp_0010020

Basic information

TDR Targets ID: 972930
Schistosoma japonicum, expressed protein
Source Database / ID:  Wormbase Parasite  

pI: 4.9759 | Length (AA): 322 | MW (Da): 35906 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06337   DUSP domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004843   ubiquitin-specific protease activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
84 314 4n5a (A) 129 373 10.00 0 0.01 0.787726 -0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130439)

Species Accession Gene Product
Brugia malayi Bm1_02220   Ubiquitin carboxyl-terminal hydrolase family protein
Drosophila melanogaster Dmel_CG8494   CG8494 gene product from transcript CG8494-RA
Echinococcus granulosus EgrG_000570500   ubiquitin carboxyl terminal hydrolase 20
Echinococcus multilocularis EmuJ_000570500   ubiquitin carboxyl terminal hydrolase 20
Homo sapiens ENSG00000077254   ubiquitin specific peptidase 33
Homo sapiens ENSG00000136878   ubiquitin specific peptidase 20
Leishmania braziliensis LbrM.09.0240   ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania donovani LdBPK_090390.1   cysteine peptidase, Clan CA, family C19, putative
Leishmania infantum LinJ.09.0390   ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania major LmjF.09.0240   ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania mexicana LmxM.09.0240   ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Loa Loa (eye worm) LOAG_01666   ubiquitin carboxyl-terminal hydrolase
Mus musculus ENSMUSG00000025437   ubiquitin specific peptidase 33
Mus musculus ENSMUSG00000026854   ubiquitin specific peptidase 20
Schistosoma japonicum Sjp_0010020   expressed protein
Schistosoma mansoni Smp_021300   family C19 unassigned peptidase (C19 family)
Schmidtea mediterranea mk4.000671.11  
Schmidtea mediterranea mk4.010340.00  
Schmidtea mediterranea mk4.004596.00   Ubiquitin carboxyl-terminal hydrolase
Trypanosoma brucei gambiense Tbg972.11.13680   Ubiquitin carboxyl-terminal hydrolase
Trypanosoma brucei Tb927.11.12240   cysteine peptidase, Clan CA, family C19, putative
Trypanosoma congolense TcIL3000.11.12870   cysteine peptidase, Clan CA, family C19, putative
Trypanosoma cruzi TcCLB.511127.120   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma cruzi TcCLB.509023.120   cysteine peptidase, Clan CA, family C19, putative

Essentiality

Sjp_0010020 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4060 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4060 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.4060 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.4060 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Sjp_0010020 (Schistosoma japonicum), expressed protein
Title for this comment
Comment