pI: 8.665 |
Length (AA): 495 |
MW (Da): 56370 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 81 | 3v2y (A) | 30 | 92 | 29.00 | 0.00026 | 0.03 | 0.15713 | 2.05 |
42 | 381 | 4amj (A) | 50 | 357 | 43.00 | 0 | 1 | 0.848959 | 0.38 |
42 | 382 | 2rh1 (A) | 42 | 341 | 38.00 | 0 | 1 | 0.718983 | 0.4 |
42 | 382 | 3kj6 (A) | 42 | 341 | 49.00 | 0 | 0.99 | 0.467983 | 1.8 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128924)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_F16D3.7 | Protein SER-5 |
Caenorhabditis elegans | CELE_C52B11.3 | Protein DOP-4 |
Drosophila melanogaster | Dmel_CG18741 | Dopamine 1-like receptor 2 |
Homo sapiens | ENSG00000171873 | adrenoceptor alpha 1D |
Homo sapiens | 147 | adrenoceptor alpha 1B |
Homo sapiens | ENSG00000113749 | histamine receptor H2 |
Mus musculus | ENSMUSG00000034987 | histamine receptor H2 |
Mus musculus | ENSMUSG00000050541 | adrenergic receptor, alpha 1b |
Mus musculus | 11550 | adrenergic receptor, alpha 1d |
Schistosoma japonicum | Sjp_0026520 | Alpha-1D adrenergic receptor, putative |
Schistosoma japonicum | Sjp_0095180 | ko:K04135 adrenergic receptor, alpha 1a, putative |
Schistosoma mansoni | Smp_150180 | amine GPCR |
Schmidtea mediterranea | mk4.000742.09 | Dopamine receptor 4 |
Schmidtea mediterranea | mk4.029836.00 | |
Schmidtea mediterranea | mk4.011371.00 | Dopamine receptor 4 |
Schmidtea mediterranea | mk4.003202.01 | Dopamine receptor 4 |
Schmidtea mediterranea | mk4.012659.00 | Dopamine receptor 4 |
Schmidtea mediterranea | mk4.028983.00 | Putative g-protein coupled receptor |
Schmidtea mediterranea | mk4.031359.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | adrenergic receptor, alpha 1b | Compounds | References |
Rattus norvegicus | Histamine H2 receptor | Compounds | References |
Cavia porcellus | Histamine H2 receptor | Compounds | References |
Mesocricetus auratus | Alpha-1b adrenergic receptor | Compounds | References |
Rattus norvegicus | Alpha-1b adrenergic receptor | Compounds | References |
Mus musculus | adrenergic receptor, alpha 1d | Compounds | References |
Homo sapiens | histamine receptor H2 | Compounds | References |
Homo sapiens | adrenoceptor alpha 1B | Compounds | References |
Rattus norvegicus | Alpha-1d adrenergic receptor | Compounds | References |
Homo sapiens | adrenoceptor alpha 1D | Compounds | References |