Detailed view for OVOC280

Basic information

TDR Targets ID: 984379
Onchocerca volvulus, Putative pyridoxal kinase
Source Database / ID:  Wormbase Parasite  

pI: 4.6957 | Length (AA): 651 | MW (Da): 72955 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00294  

Gene Ontology

Mouse over links to read term descriptions.
GO:0009443   pyridoxal 5'-phosphate salvage  
GO:0008478   pyridoxal kinase activity  

Metabolic Pathways

Vitamin B6 metabolism (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 318 2f7k (A) 0 312 41.00 0 1 1.51042 -0.83
110 200 4jjp (A) 89 179 32.00 0.000035 1 0.814275 -1.36
150 200 1rkd (A) 175 225 33.00 0.000064 1 0.669275 -0.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127394)

Species Accession Gene Product
Arabidopsis thaliana AT5G37850   Pyridoxal kinase
Brugia malayi Bm1_07835   pyridoxal kinase
Candida albicans CaO19.3411   same as N terminus of cosmid orf Ca20C1.16
Candida albicans CaO19.9387   similar to BUD17-like CaP19.3411
Candida albicans CaO19.1828   similar to BUD17-like CaP19.3411
Candida albicans CaO19.10914   similar to N terminus of S. cerevisiae BUD17 (YNR027W)
Caenorhabditis elegans CELE_F57C9.1   Protein F57C9.1, isoform A
Dictyostelium discoideum DDB_G0268628   pyridoxal kinase
Drosophila melanogaster Dmel_CG34455   Pyridoxal kinase
Escherichia coli b1636   pyridoxamine kinase
Escherichia coli b2418   pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase
Echinococcus granulosus EgrG_000600600   pyridoxal kinase
Entamoeba histolytica EHI_126090   pyridoxal kinase, putative
Echinococcus multilocularis EmuJ_000600600   pyridoxal kinase
Homo sapiens ENSG00000160209   pyridoxal (pyridoxine, vitamin B6) kinase
Leishmania braziliensis LbrM.30.1370   Pyridoxal kinase, putative
Leishmania donovani LdBPK_301310.1   pyridoxal kinase, putative
Leishmania infantum LinJ.30.1310   Pyridoxal kinase, putative
Leishmania major LmjF.30.1250   Pyridoxal kinase, putative
Leishmania mexicana LmxM.29.1250   Pyridoxal kinase, putative
Loa Loa (eye worm) LOAG_01254   hypothetical protein
Mus musculus 102641556   mucin-1-like
Mus musculus ENSMUSG00000032788   pyridoxal (pyridoxine, vitamin B6) kinase
Oryza sativa 4352717   Os12g0600400
Onchocerca volvulus OVOC280   Putative pyridoxal kinase
Plasmodium berghei PBANKA_1230800   pyridoxal kinase, putative
Plasmodium falciparum PF3D7_0616000   pyridoxal kinase
Plasmodium knowlesi PKNH_1134000   pyridoxal kinase, putative
Plasmodium vivax PVX_113935   pyridoxal kinase, putative
Plasmodium yoelii PY01633   putative pyridoxine kinase
Saccharomyces cerevisiae YEL029C   putative pyridoxal kinase BUD16
Saccharomyces cerevisiae YNR027W   putative pyridoxal kinase BUD17
Schistosoma japonicum Sjp_0098930   ko:K00868 pyridoxine kinase [EC2.7.1.35], putative
Schistosoma mansoni Smp_164250.1   pyridoxine kinase
Schistosoma mansoni Smp_164250.2   pyridoxine kinase
Schmidtea mediterranea mk4.008081.02  
Schmidtea mediterranea mk4.000800.10  
Schmidtea mediterranea mk4.004639.00   Putative pyridoxal kinase
Schmidtea mediterranea mk4.010590.00  
Schmidtea mediterranea mk4.010030.00  
Trypanosoma brucei gambiense Tbg972.6.2510   pyridoxal kinase
Trypanosoma brucei Tb927.6.2740   pyridoxal kinase
Trypanosoma congolense TcIL3000_0_21240   pyridoxal kinase
Trypanosoma cruzi TcCLB.509059.50   pyridoxal kinase, putative
Trypanosoma cruzi TcCLB.507925.40   pyridoxal kinase, putative
Trichomonas vaginalis TVAG_493290   phosphomethylpyrimidine kinase, putative
Trichomonas vaginalis TVAG_425810   phosphomethylpyrimidine kinase, putative
Trichomonas vaginalis TVAG_132920   pyridoxine kinase, putative

Essentiality

OVOC280 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.2740 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.2740 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.2740 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.2740 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1636 Escherichia coli non-essential goodall
b2418 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens pyridoxal (pyridoxine, vitamin B6) kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC280 (Onchocerca volvulus), Putative pyridoxal kinase
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