Detailed view for PF3D7_0819200

Basic information

TDR Targets ID: 985
Plasmodium falciparum, perforin-like protein 5
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.0467 | Length (AA): 676 | MW (Da): 79405 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01823   MAC/Perforin domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
58 237 4u5a (C) 47 234 20.00 0.27 0.2 0.385472 -0.04
70 482 4haw (C) 657 1052 12.00 0 0.64 0.284447 0.4
71 289 2ab5 (A) 310 511 30.00 0.06 0.6 0.278165 1.37
75 481 4hat (C) 677 1051 12.00 0 0.81 0.270571 0.62
122 333 3jqq (A) 61 313 27.00 0.41 0.92 0.297009 1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Ring. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, Oocyst, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_167111)

Species Accession Gene Product
Plasmodium berghei PBANKA_0711600   perforin-like protein 5
Plasmodium falciparum PF3D7_0819200   perforin-like protein 5
Plasmodium knowlesi PKNH_1313000   perforin-like protein 5, putative
Plasmodium vivax PVX_089405   perforin-like protein 5
Plasmodium yoelii PY03943   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.029 0.5 0.5
0.0217 0.4392 1
0.0022 0.3918 0.5
0.0227 1 1
0.0175 0.4943 1
0.003 0.5305 1
0.0055 0.3362 0.5
0.003 0.5305 1
0.0081 0.4635 1
0.0009 0.5 0.5
0.0217 0.4392 1
0.0094 0.5443 1
0.0174 0.4917 1
0.0061 1 0.5
0.0009 0.5 0.5
0.004 0.5 0.5
0.0009 0.5 0.5
0.0153 1 1
0.0281 1 1
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0199 0.5 0.5
0.0009 0.5 0.5
0.0087 0.4303 1
0.0121 0.3049 1
0.0231 0.6527 1
0.0053 1 1
0.0108 1 1
0.0127 0.744 1
0.0045 1 1
0.0181 0.2781 0.5
0.0023 0.2782 0
0.0143 0.3796 1
0.0208 0.3903 0.5
0.0199 0.5 0.5
0.0208 0.3903 0.5
0.0212 0.4318 1
0.0185 1 1
0.0175 1 1
0.021464 0.5 0.5
0.0231 0.6527 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0819200 (Plasmodium falciparum), perforin-like protein 5
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