Detailed view for OVOC2439

Basic information

TDR Targets ID: 986933
Onchocerca volvulus, Dehydrogenase\/reductase SDR family member 1 homolog
Source Database / ID:  Wormbase Parasite  

pI: 9.8557 | Length (AA): 71 | MW (Da): 8210 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 698 3zkv (A) 244 965 10.00 0 1 0.484666 0.46
1072 1364 4l4x (A) 193 482 24.00 0.00000077 1 0.284927 0.93
1147 1348 1gee (A) 3 193 30.00 0.00000000044 1 0.511896 -0.57
1148 1193 2d5c (A) 114 157 43.00 0.35 0.81 0.564557 -0.74
1148 1416 2ae2 (A) 6 260 29.00 0 1 0.555567 -0.64
1148 1414 2qq5 (A) 4 262 48.00 0 1 0.707204 -0.78
1149 1435 5yss (A) 3 250 31.00 0.0000000085 1 0.472837 -0.5
1149 1349 5ig2 (A) 4 194 27.00 0 1 0.433014 -0.87
1149 1301 2dtx (A) 5 132 39.00 0.00011 1 0.349494 -0.08
1149 1242 2q45 (A) 12 99 32.00 0.000093 1 0.561276 -1.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136180)

Species Accession Gene Product
Brugia malayi Bm1_31840   oxidoreductase, short chain dehydrogenase/reductase family protein
Dictyostelium discoideum DDB_G0287899   hypothetical protein
Homo sapiens ENSG00000080345   replication timing regulatory factor 1
Loa Loa (eye worm) LOAG_07389   hypothetical protein
Mus musculus ENSMUSG00000036202   Rap1 interacting factor 1 homolog (yeast)
Oryza sativa 4340275   Os06g0173000
Onchocerca volvulus OVOC2439   Dehydrogenase\/reductase SDR family member 1 homolog

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.007 0.2916 0.4349
0.0165 1 0.5
0.007 1 1
0.0218 0.5 0.5
0.0012 0.5 0.5
0.0118 1 0.5
0.007 0.2916 0.4349
0.0097 0.4304 1
0.0027 0.5 0.5
0.0073 0.3141 0.5
0.0132 0.3658 0.3658
0.0088 0.6544 0.5
0.0102 0.7451 0.5
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0114 1 1
0.0097 1 0.5
0.0035 1 0.5
0.0073 0.2873 0
0.0021 0.5 0.5
0.0119 0.2746 1
0.0009 0.7374 0
0.0196 0.8679 1
0.0046 0.3082 0.5
0.0021 0.3321 0.5
0.0171 0.4063 0.5
0.0004 0.5 0.5
0.0073 0.3811 0.5
0.016 0.577 1
0.0009 0.5 0.5
0.0162 1 0.5
0.0108 0.5 0.5
0.0089 0.5 0.5
0.0131 0.5 0.5
0.0402 1 1
0.0013 1 1
0.0016 0.5 0.5
0.0056 1 0.5
0.0056 0.875 0.5
0.0082 1 0.5
0.0057 0.284 0.6532
0.0073 0.3811 0.5
0.0009 0.5 0.5
0.0012 0.5 0.5
0.0084 0.4283 1
0.0053 1 1
0.0013 0.5 0.5
0.0085 1 0.5
0.007 0.2916 0.4349
0.0089 0.5 0.5
0.0058 0.3931 0.5
0.016 0.577 1
0.0222 0.5 0.5
0.0157 0.5 0.5
0.0071 0.3141 0.5
0.0067 0.3468 0
0.011 0.3568 0.7185
0.0066 0.3586 0.5
0.0005 0.5 0.5
0.0068 0.2585 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0106 0.2872 0.4466
0.0004 0.5 0.5
0.0019 0.4322 0.4322
0.0068 1 0.5
0.008 0.5 0.5
0.0196 0.8679 1
0.007 1 1
0.0113 1 0.5
0.0088 1 0.5
0.0005 0.5 0.5
0.0009 1 0.5
0.0106 0.5 0.5
0.0123 0.5 0.5
0.0106 1 1
0.0196 0.8679 1
0.0004 0.5 0.5
0.0106 1 0.5
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0408 0.5144 1
0.007 1 1
0.0053 1 0.5
0.0114 1 1
0.0093 0.5 0.5
0.0408 0.5144 1
0.0171 0.4063 0.5
0.0073 0.4546 0.8763
0.0045 1 0.5
0.0039 1 0.5
0.0032 1 1
0.0009 0.5 0.5
0.0068 1 1
0.0004 0.5 0.5
0.0058 1 0.5
0.0064 0.3508 1
0.0087 0.5 0.5
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0408 0.5144 1
0.0009 0.5 0.5
0.0021 0.3321 0.5
0.0076 1 0.5
0.0026 0.5 0.5
0.004 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC2439 (Onchocerca volvulus), Dehydrogenase\/reductase SDR family member 1 homolog
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