pI: 7.0447 |
Length (AA): 1093 |
MW (Da): 121899 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 190 | 4v0h (A) | 20 | 239 | 41.00 | 0 | 1 | 1.54259 | -1.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_132377)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_09835 | hypothetical protein |
Brugia malayi | Bm1_01940 | metallo-beta-lactamase superfamily protein |
Caenorhabditis elegans | CELE_F53B1.6 | Protein F53B1.6 |
Caenorhabditis elegans | CELE_B0432.9 | Protein B0432.9 |
Drosophila melanogaster | Dmel_CG9117 | CG9117 gene product from transcript CG9117-RA |
Echinococcus granulosus | EgrG_000616700 | metallo beta lactamase domain containing protein |
Echinococcus multilocularis | EmuJ_000616700 | metallo beta lactamase domain containing protein |
Homo sapiens | ENSG00000214309 | metallo-beta-lactamase domain containing 1 |
Loa Loa (eye worm) | LOAG_07501 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12920 | metallo-beta-lactamase superfamily protein |
Mus musculus | ENSMUSG00000049285 | metallo-beta-lactamase domain containing 1 |
Mycobacterium tuberculosis | Rv1913 | Conserved hypothetical protein |
Onchocerca volvulus | OVOC3197 |
|
Onchocerca volvulus | OVOC2590 |
|
Schistosoma japonicum | Sjp_0014920 | Beta-lactamase-like protein LOC255374 homolog, putative |
Schistosoma mansoni | Smp_043930 | hypothetical protein |
Schmidtea mediterranea | mk4.018452.00 | |
Schmidtea mediterranea | mk4.003521.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 24.6% | 281 aa | Compounds | References |
Oryctolagus cuniculus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 23.1% | 281 aa | Compounds | References |
Bos taurus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 24.9% | 281 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 27.9% | 161 aa | Compounds | References |
Bos taurus | Casein kinase I isoform alpha | 325 aa | 21.4% | 290 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 36.9% | 203 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 24.0% | 267 aa | Compounds | References |