pI: 7.272 |
Length (AA): 306 |
MW (Da): 35261 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 44 | 4tq0 (B) | 13 | 47 | 32.00 | 0.066 | 0.09 | 0.143494 | 1.83 |
27 | 203 | 4uos (A) | 7 | 183 | 18.00 | 0.34 | 0.54 | 0.549552 | -1.09 |
63 | 179 | 4hse (A) | 377 | 514 | 26.00 | 0.38 | 0.7 | 0.366857 | 0.21 |
65 | 218 | 5cwp (A) | 32 | 190 | 14.00 | 0 | 0.05 | 0.401985 | -1.04 |
69 | 225 | 5j1g (A) | 1004 | 1150 | 13.00 | 0 | 0.09 | 0.32742 | -0.66 |
110 | 216 | 2elb (A) | 24 | 133 | 9.00 | 0 | 0.01 | 0.237841 | -0.66 |
143 | 550 | 5mzh (A) | 20 | 416 | 16.00 | 0.00026 | 1 | 0.84303 | 0.62 |
275 | 500 | 1gxr (A) | 540 | 760 | 23.00 | 0.0001 | 0.8 | 0.57562 | 0.45 |
492 | 550 | 6e29 (A) | 37 | 93 | 39.00 | 0.0049 | 0.87 | 0.587084 | -0.42 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129719)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G50230 | WD40 domain-containing protein |
Brugia malayi | Bm1_33655 | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X |
Caenorhabditis elegans | CELE_K06A1.5 | Protein ATG-16.2 |
Caenorhabditis elegans | CELE_F02E8.5 | Protein ATG-16.1 |
Dictyostelium discoideum | DDB_G0275323 | autophagy protein 16 |
Drosophila melanogaster | Dmel_CG31033 | Autophagy-specific gene 16 |
Echinococcus granulosus | EgrG_001095900 | family S9 non peptidase ue S09 family |
Echinococcus granulosus | EgrG_000150900 | U6 snRNA associated Sm protein LSm7 |
Entamoeba histolytica | EHI_168370 | WD domain containing protein |
Echinococcus multilocularis | EmuJ_000150900 | U6 snRNA associated Sm protein LSm7 |
Echinococcus multilocularis | EmuJ_001095900 | family S9 non peptidase ue (S09 family) |
Homo sapiens | ENSG00000085978 | autophagy related 16-like 1 (S. cerevisiae) |
Leishmania braziliensis | LbrM.33.1680 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_331500.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.33.1500 | hypothetical protein, conserved |
Leishmania major | LmjF.33.1410 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.32.1410 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_10334 | hypothetical protein |
Mus musculus | ENSMUSG00000026289 | autophagy related 16-like 1 (S. cerevisiae) |
Oryza sativa | 4334090 | Os03g0746600 |
Onchocerca volvulus | OVOC2829 |
|
Schistosoma japonicum | Sjp_0068360 | Autophagy-related protein 16-1, putative |
Schistosoma mansoni | Smp_135430 | family S9 non-peptidase homologue (S09 family) |
Schmidtea mediterranea | mk4.000410.00 | |
Trypanosoma brucei gambiense | Tbg972.11.7880 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.6960 | ATG16/SAP18/CVT11/APG16, putative |
Trypanosoma cruzi | TcCLB.506775.160 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511167.20 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_459010 | WD-repeat protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4790 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4790 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4790 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4790 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Jak1 protein | 210 aa | 26.6% | 192 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 47.6% | 170 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 37.2% | 304 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 39.8% | 294 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 38.7% | 302 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 39.4% | 287 aa | Compounds | References |