Detailed view for OVOC1629

Basic information

TDR Targets ID: 992533
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.1302 | Length (AA): 60 | MW (Da): 7052 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00916  
PF01740  
PF13792  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008271   secondary active sulfate transmembrane transporter activity  
GO:0055085   transmembrane transport  
GO:0008272   sulfate transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
500 650 3llo (A) 506 711 25.00 0 1 0.280758 0.36
522 653 1auz (A) 4 113 17.00 0 0.81 0.228182 0.02
522 648 1vc1 (A) 6 110 19.00 0 1 0.333925 -0.82
571 644 3gue (A) 203 302 38.00 0.96 0.2 0.078502 1.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126650)

Species Accession Gene Product
Arabidopsis thaliana AT5G19600   5
Arabidopsis thaliana AT4G08620   1
Arabidopsis thaliana AT4G02700   2
Arabidopsis thaliana AT3G15990   4
Arabidopsis thaliana AT1G22150   3
Arabidopsis thaliana AT5G13550   1
Arabidopsis thaliana AT1G23090   sulfate transporter 3.3
Arabidopsis thaliana AT1G77990   sulfate transporter 2
Arabidopsis thaliana AT5G10180   1
Arabidopsis thaliana AT1G78000   2
Arabidopsis thaliana AT3G12520   2
Arabidopsis thaliana AT3G51895   1
Brugia malayi Bm1_44800   sulfate permease family protein
Candida albicans CaO19.9696   similar to S. cerevisiae YPR003C
Candida albicans CaO19.10252   one of three potential sulfate transporter genes
Candida albicans CaO19.2149   similar to S. cerevisiae YPR003C
Caenorhabditis elegans CELE_ZK287.2   Protein SULP-8, isoform A
Caenorhabditis elegans CELE_K12G11.1   Protein SULP-4
Caenorhabditis elegans CELE_K12G11.2   Protein SULP-5
Caenorhabditis elegans CELE_F14D12.5   Protein SULP-2
Cryptosporidium hominis Chro.70021   high affinity sulfate transporter-related
Cryptosporidium parvum cgd7_90   high affinity sulfate transporter-related
Dictyostelium discoideum DDB_G0268074   hypothetical protein
Dictyostelium discoideum DDB_G0276663   hypothetical protein
Dictyostelium discoideum DDB_G0268060   hypothetical protein
Dictyostelium discoideum DDB_G0286611   RNA recognition motif-containing protein RRM
Drosophila melanogaster Dmel_CG7005   Epidermal stripes and patches
Drosophila melanogaster Dmel_CG5485   CG5485 gene product from transcript CG5485-RA
Drosophila melanogaster Dmel_CG9717   CG9717 gene product from transcript CG9717-RA
Drosophila melanogaster Dmel_CG5002   CG5002 gene product from transcript CG5002-RA
Drosophila melanogaster Dmel_CG7912   CG7912 gene product from transcript CG7912-RA
Drosophila melanogaster Dmel_CG9702   CG9702 gene product from transcript CG9702-RA
Drosophila melanogaster Dmel_CG6928   CG6928 gene product from transcript CG6928-RD
Echinococcus granulosus EgrG_000868450   solute carrier family 26 prestin
Echinococcus multilocularis EmuJ_000724200   solute carrier family 26
Echinococcus multilocularis EmuJ_000868450   solute carrier family 26, (prestin)
Homo sapiens ENSG00000225697   solute carrier family 26 (anion exchanger), member 6
Homo sapiens ENSG00000181045   solute carrier family 26 (anion exchanger), member 11
Homo sapiens ENSG00000170615   solute carrier family 26 (anion exchanger), member 5
Leishmania braziliensis LbrM.30.0850   sulfate transporter-like protein
Leishmania donovani LdBPK_281810.1   sulfate transporter-like protein
Leishmania infantum LinJ.28.1810   sulfate transporter-like protein
Leishmania major LmjF.28.1690   sulfate transporter-like protein
Leishmania mexicana LmxM.28.1690   sulfate transporter-like protein
Loa Loa (eye worm) LOAG_04536   sulfate permease
Loa Loa (eye worm) LOAG_11998   hypothetical protein
Loa Loa (eye worm) LOAG_13655   hypothetical protein
Mus musculus ENSMUSG00000023259   solute carrier family 26, member 6
Mus musculus ENSMUSG00000039908   solute carrier family 26, member 11
Mus musculus ENSMUSG00000029015   solute carrier family 26, member 5
Mycobacterium tuberculosis Rv1739c   Probable sulphate-transport transmembrane protein ABC transporter
Neospora caninum NCLIV_056370   hypothetical protein
Oryza sativa 4345528   Os08g0406400
Oryza sativa 9266924   Os01g0593700
Oryza sativa 4331935   Os03g0195800
Oryza sativa 4331703   Os03g0161200
Oryza sativa 4331932   Os03g0195300
Oryza sativa 4340095   Os06g0143700
Oryza sativa 4331937   Os03g0196000
Oryza sativa 4346475   Os09g0240500
Oryza sativa 4337235   Os04g0652400
Oryza sativa 4324697   Os01g0719300
Onchocerca volvulus OVOC1629  
Saccharomyces cerevisiae YPR003C   hypothetical protein
Saccharomyces cerevisiae YBR294W   Sul1p
Saccharomyces cerevisiae YLR092W   Sul2p
Schistosoma japonicum Sjp_0011080   expressed protein
Schistosoma japonicum Sjp_0114830   Chloride anion exchanger, putative
Schistosoma japonicum Sjp_0206530   ko:K04602 cadherin EGF LAG seven-pass G-type receptor 3 (flamingo), putative
Schistosoma japonicum Sjp_0128740   Solute carrier family 26 member 6, putative
Schistosoma mansoni Smp_145320   sulfate transporter
Schmidtea mediterranea mk4.004847.00   Testis anion transporter 1
Schmidtea mediterranea mk4.016110.00   Putative sulfate transporter
Schmidtea mediterranea mk4.017286.00   Testis anion transporter 1
Schmidtea mediterranea mk4.009555.04  
Schmidtea mediterranea mk4.010473.00   Testis anion transporter 1
Schmidtea mediterranea mk4.009555.03  
Schmidtea mediterranea mk4.000324.01  
Schmidtea mediterranea mk4.004847.01   Putative sulfate transporter
Schmidtea mediterranea mk4.028097.00  
Schmidtea mediterranea mk4.009555.02   Testis anion transporter 1
Schmidtea mediterranea mk4.004094.00   Putative sulfate transporter
Schmidtea mediterranea mk4.005240.01  
Schmidtea mediterranea mk4.000324.02   Sodium-independent sulfate anion transporter
Schmidtea mediterranea mk4.009555.00  
Schmidtea mediterranea mk4.021966.00   Putative sulfate transporter
Toxoplasma gondii TGME49_324900   hypothetical protein

Essentiality

OVOC1629 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1769 Mycobacterium tuberculosis non-essential nmpdr
TGME49_324900 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0458 0.2623 0.5
0.0803988 0.299357 1
0.0803988 0.299357 1
0.0271 0.2672 1
0.025586 0.310537 0.398337
0.0803988 0.299357 1
0.0803988 0.299357 1
0.0238 0.5752 1
0.05657 0.255418 0.5
0.0233 0.5989 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier OVOC1629 (Onchocerca volvulus),
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