Detailed view for OVOC4007

Basic information

TDR Targets ID: 993574
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.7155 | Length (AA): 574 | MW (Da): 66204 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 88 4k6l (G) 23 90 32.00 0.99 0.07 0.29172 0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_179119)

Species Accession Gene Product
Brugia malayi Bm1_54520   hypothetical protein
Caenorhabditis elegans CELE_H12D21.9   Protein H12D21.9
Loa Loa (eye worm) LOAG_04467   hypothetical protein
Onchocerca volvulus OVOC4007  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Orexin receptor 2 460 aa 22.5% 417 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 19.4% 330 aa Compounds References
Rattus norvegicus Galanin receptor 1 346 aa 26.0% 381 aa Compounds References
Bos taurus Dopamine receptor 446 aa 21.4% 359 aa Compounds References
Rattus norvegicus Nociceptin/mu opioid receptor 398 aa 26.3% 376 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 22.4% 58 aa Compounds References
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 359 aa 24.4% 386 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 20.6% 326 aa Compounds References
Sus scrofa Type-1 angiotensin II receptor 359 aa 24.5% 387 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 20.1% 314 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 20.8% 336 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 26.1% 299 aa Compounds References
Cavia porcellus Platelet activating factor receptor 342 aa 20.3% 394 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 19.5% 338 aa Compounds References
Bos taurus Endothelin receptor ET-B 441 aa 20.5% 371 aa Compounds References
Mesocricetus auratus Neurokinin 2 receptor 384 aa 20.9% 401 aa Compounds References
Danio rerio Mu opioid receptor-like OR2 384 aa 24.5% 371 aa Compounds References
Rattus norvegicus Mu opioid receptor 398 aa 26.3% 376 aa Compounds References
Rattus norvegicus Angiotensin II receptor 359 aa 24.9% 386 aa Compounds References
Rattus norvegicus Melanin-concentrating hormone receptor 1 360 aa 25.7% 374 aa Compounds References
Rattus norvegicus Type-1B angiotensin II receptor 359 aa 24.4% 386 aa Compounds References
Oryctolagus cuniculus Bradykinin B2 receptor 367 aa 19.5% 313 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 5 445 aa 20.7% 415 aa Compounds References
Cavia porcellus Histamine H2 receptor 359 aa 23.4% 303 aa Compounds References
Rattus norvegicus Endothelin receptor ET-B 442 aa 20.9% 445 aa Compounds References
Macaca mulatta Mu-type opioid receptor 400 aa 25.7% 381 aa Compounds References
Sus scrofa Endothelin receptor ET-B 443 aa 20.5% 371 aa Compounds References
Cavia porcellus Type-1 angiotensin II receptor 359 aa 25.6% 391 aa Compounds References
Rattus norvegicus Platelet activating factor receptor 341 aa 21.2% 378 aa Compounds References
Bos taurus Dopamine D1 receptor 446 aa 21.4% 359 aa Compounds References
Rattus norvegicus Neuropeptide FF receptor 2 417 aa 21.0% 352 aa Compounds References
Cavia porcellus Mu-opioid receptor 400 aa 25.5% 381 aa Compounds References
Rattus norvegicus Bombesin receptor subtype-3 399 aa 21.6% 371 aa Compounds References
Sus scrofa Serotonin 4 (5-HT4) receptor 402 aa 23.1% 359 aa Compounds References
Rattus norvegicus Bradykinin B2 receptor 396 aa 19.6% 317 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 20.5% 341 aa Compounds References
Rattus norvegicus Type-1A angiotensin II receptor 359 aa 24.9% 386 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 20.0% 310 aa Compounds References
Rattus norvegicus Neuromedin B receptor 390 aa 22.2% 387 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 17.9% 347 aa Compounds References
Rattus norvegicus Dopamine D1 receptor 446 aa 21.0% 357 aa Compounds References
Macaca mulatta CXC chemokine receptor 3 368 aa 20.6% 306 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 20.8% 308 aa Compounds References
Cavia porcellus Kappa opioid receptor 380 aa 27.5% 374 aa Compounds References
Rattus norvegicus Somatostatin receptor 1 391 aa 25.3% 396 aa Compounds References
Cricetulus griseus Prokineticin receptor 2 391 aa 20.9% 330 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 19.0% 331 aa Compounds References
Cavia porcellus Bradykinin B2 receptor 372 aa 20.7% 323 aa Compounds References
Rattus norvegicus Adrenergic receptor alpha 515 aa 20.3% 429 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 19.4% 309 aa Compounds References
Bos taurus Angiotensin II type 1a (AT-1a) receptor 359 aa 25.1% 399 aa Compounds References
Sus scrofa Dopamine D1 receptor 446 aa 21.3% 357 aa Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor 406 aa 22.8% 386 aa Compounds References
Rattus norvegicus Neurotensin receptor 1 424 aa 23.6% 420 aa Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor 388 aa 22.1% 357 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 5 352 aa 20.4% 363 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 23.7% 299 aa Compounds References
Rattus norvegicus Somatostatin receptor 2 369 aa 24.9% 350 aa Compounds References
Bos taurus Rhodopsin 348 aa 19.0% 300 aa Compounds References
Rattus norvegicus Bradykinin B1 receptor 337 aa 19.6% 306 aa Compounds References
Rattus norvegicus C-X-C chemokine receptor type 4 349 aa 23.6% 402 aa Compounds References
Rattus norvegicus Delta opioid receptor 372 aa 22.8% 386 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 26.3% 403 aa Compounds References
Bos taurus Beta-2 adrenergic receptor 418 aa 20.2% 337 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 4 375 aa 21.7% 410 aa Compounds References
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor 359 aa 25.3% 399 aa Compounds References
Macaca mulatta Melanin-concentrating hormone receptor 1 388 aa 25.1% 419 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 19.0% 331 aa Compounds References
Rattus norvegicus Somatostatin receptor 363 aa 24.0% 313 aa Compounds References
Macaca mulatta C-C chemokine receptor type 5 352 aa 20.4% 363 aa Compounds References
Cavia porcellus Cholecystokinin A receptor 430 aa 22.3% 377 aa Compounds References
Rattus norvegicus Somatostatin receptor 5 363 aa 24.0% 313 aa Compounds References
Cavia porcellus mu/kappa opioid receptor 380 aa 27.5% 374 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 1 382 aa 22.8% 378 aa Compounds References
Rattus norvegicus Neurokinin 2 receptor 390 aa 22.1% 398 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 20.3% 316 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 20.5% 341 aa Compounds References
Sus scrofa Angiotensin type II receptor 137 aa 27.5% 120 aa Compounds References
Macaca mulatta C-X-C chemokine receptor type 4 352 aa 24.3% 374 aa Compounds References
Rattus norvegicus Alpha-1b adrenergic receptor 515 aa 20.3% 429 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 26.1% 299 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 18.8% 309 aa Compounds References
Rattus norvegicus Opioid receptor 372 aa 22.8% 386 aa Compounds References
Bos taurus Mu opioid receptor 401 aa 26.7% 341 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 19.2% 308 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier OVOC4007 (Onchocerca volvulus),
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