Detailed view for ML1257
Basic information
Mycobacterium leprae, Probable histidinol dehydrogenase HisD (HDH)
Source Database / ID: Leproma
pI: 5.3872 |
Length (AA): 449 |
MW (Da): 46796 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0051287 NAD binding
GO:0016491 oxidoreductase activity
GO:0008270 zinc ion binding
GO:0008152 metabolic process
GO:0000105 histidine biosynthetic process
GO:0055114 oxidation reduction
Metabolic Pathways
Structural information
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 10 | 448 | 1kae (A) | 5 | 428 | 37.00 | 0 | 1 | 1.39433 | -0.06 |
| 14 | 448 | 4g09 (A) | 5 | 429 | 41.00 | 0 | 1 | 1.42242 | 0.07 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_129099)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT5G63890 | Histidinol dehydrogenase |
| Candida albicans | CaO19.5639 | Phosphoribosyl-AMP cyclohydrolase |
| Candida albicans | CaO19.13084 | Phosphoribosyl-AMP cyclohydrolase |
| Escherichia coli | b2020 | bifunctional histidinal dehydrogenase/histidinol dehydrogenase |
| Mycobacterium leprae | ML1257 | Probable histidinol dehydrogenase HisD (HDH) |
| Mycobacterium tuberculosis | Rv1599 | Probable histidinol dehydrogenase HisD (HDH) |
| Mycobacterium ulcerans | MUL_1572 | histidinol dehydrogenase |
| Oryza sativa | 4324282 | Os01g0232700 |
| Saccharomyces cerevisiae | YCL030C | trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase |
Essentiality
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| b2020 | Escherichia coli | non-essential | goodall |
-
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Brassica oleracea var. capitata | Histidinol dehydrogenase | Compounds | References |
| Escherichia coli | bifunctional histidinal dehydrogenase/histidinol dehydrogenase | Compounds | References |
| Brucella suis biovar 1 (strain 1330) | Histidinol dehydrogenase | Compounds | References |
By sequence similarity to non orthologous druggable targets
Obtained from network model
Ranking Plot
Putative Drugs List
Assayability
Assay information
Reagent availability
Bibliographic References