Detailed view for Rv0003

Basic information

TDR Targets ID: 6990
Mycobacterium tuberculosis, DNA REPLICATION AND REPAIR PROTEIN RECF (SINGLE-STRAND DNA BINDING PROTEIN)
Source Database / ID: Tuberculist / Rv0003 

pI: 7.201 | Length (AA): 386 | MW (Da): 42180 | Number of Paralogs: 0

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF02463   SMC_N

Gene Ontology

Component: (mouse over links to read term descriptions)

GO:0005694   chromosome  

Function: (mouse over links to read term descriptions)

GO:0003697   single-stranded DNA binding  
GO:0005524   ATP binding  

Process: (mouse over links to read term descriptions)

GO:0006281   DNA repair  
Metabolic Pathways

Homologous recombination (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Rv0003  

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 18
Cumulative epitope score: 20.6
Normalized epitope score: 5.3
Percentile: 77.6 (this protein belongs to the top 22.4% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_18130
Number of Paralogs: 0

Ortholog group members from selected species:
Escherichia coli K12 NP_418155.1   recombination protein F [Escherichia coli K12]... |   OrthoMCL
Mycobacterium leprae strain TN ML0003   Probable DNA replication and repair protein RecF... |   OrthoMCL
Mycobacterium tuberculosis Rv0003 (this record).   DNA REPLICATION AND REPAIR PROTEIN RECF (SINGLE-STRAND DNA B... |   OrthoMCL
Wolbachia endosymbiont of Brugia malayi Wbm0126   recombination protein F... |   OrthoMCL

Essentiality Rv0003 has essentiality data
Gene/Ortholog: mtu3 (OG4_18130); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco3579 (OG4_18130); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco3579 (OG4_18130); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3579 (OG4_18130); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3579 (OG4_18130); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

      • No orthologous druggable targets

    • By sequence similarity to non orthologous druggable targets

      • No additional associated druggable targets
    • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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