A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 6910 Mycobacterium tuberculosis, PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A) Source Database / ID: Tuberculist / Rv0009
pI: 6.23 | Length (AA): 182 | MW (Da): 19239 | Number of Paralogs: 0
EC number(s): 5.2.1.8 | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
No Pfam domain information for this protein.
Function: (mouse over links to read term descriptions)
This gene is not mapped to any metabolic pathway in KEGG.
No functional classes assigned to this gene.
Modbase 3D models: Rv0009
PDB structures: 1W74
Upregulation ranking: this gene ranks in the lower 20-40% group of genes. Shows this level of upregulation in: Dormant phase.
Upregulation ranking: this gene ranks in the lower 0-20% group of genes. Shows this level of upregulation in: Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 10 Cumulative epitope score: 11.0 Normalized epitope score: 6.0 Percentile: 94.0 (this protein belongs to the top 6.0% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_11783 Number of Paralogs: 0
Ortholog group members from selected species: Arabidopsis thaliana NP_190046 CYP71 (CYCLOPHILIN71); chromatin binding / histone binding ... | OrthoMCL Babesia bovis XP_001610877.1 peptidyl-prolyl cis-trans isomerase ... | OrthoMCL Brugia malayi Bm1_28740 cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmc... | OrthoMCL Caenorhabditis elegans Y87G2A.6 CE24686 WBGene00000891 locus:cyn-15 cyclophilin status:Parti... | OrthoMCL Cryptosporidium hominis Chro.70067 protein-related ... | OrthoMCL Cryptosporidium muris CMU_006350 peptidyl-prolyl cis-trans isomerase, cyclophilin-type famil... | OrthoMCL Cryptosporidium neoformas XP_568847 peptidyl-prolyl cis-trans isomerase ... | OrthoMCL Cryptosporidium parvum cgd7_520 cyclincyclophilin like peptidyl-prolyl cis-trans isomerase ... | OrthoMCL Drosophila melanogaster FBpp0072216 | OrthoMCL Escherichia coli K12 NP_415058.1 peptidyl-prolyl cis-trans isomerase B (rotamase B) [Escheric... | OrthoMCL Homo sapiens ENSP00000261308 | OrthoMCL Mycobacterium leprae strain TN ML0011 Probable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A)... | OrthoMCL Mus musculus ENSMUSP00000022226 | OrthoMCL Mycobacterium tuberculosis Rv0009 (this record). PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE ... | OrthoMCL Neospora caninum NCLIV_009630 | OrthoMCL Oryza sativa NP_001062485 Os08g0557500 ... | OrthoMCL Plasmodium berghei PB000833.02.0 cyclophilin, putative ... | OrthoMCL Plasmodium chabaudi PCAS_110950 cyclophilin, putative ... | OrthoMCL P. falciparum 3D7 PFE0505w cyclophilin, putative... | OrthoMCL Plasmodium knowlesi PKH_102270 cyclophilin, putative ... | OrthoMCL Plasmodium vivax PVX_098070 cyclophilin, putative... | OrthoMCL Plasmodium yoelii PY03899 putative protein-related ... | OrthoMCL Schistosoma mansoni Smp_133820 peptidyl-prolyl cis-trans isomerase-like... | OrthoMCL Toxoplasma gondii TGME49_120640 cyclophilin, putative... | OrthoMCL
[+/–] Show essentiality data references.
We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
Curated from literature
No chemical compounds is associated to this gene
Predicted associations
By orthology to known druggable targets
By sequence similarity to non orthologous druggable targets
Assay information
Assay: Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ); Source: Sigma-Aldrich Description: Automatic link to known assays based on EC numbers.
Reagent availability
No reagent availability information for this target.
User: ()
Gene identifier: Rv0009 Mycobacterium tuberculosis, PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A)
4 literature references were collected for this gene.
If you have references for this gene, please enter them in a user comment (below) or contact us.
No user comments are available for this gene.
Log in to add comments, or register.
