Identification and ranking of targets against neglected tropical diseases
TDR Targets ID: 6910 Mycobacterium tuberculosis, PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A) Source Database / ID: TubercuList / Rv0009
pI: 6.23 | Length (AA): 182 | MW (Da): 19239 | Number of Paralogs: 1 | | EC number: 5.2.1.8
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
PF00160 Pro_isomerase
Biological Process: GO:0006457 protein folding [+/–] show term definition The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
This gene is not mapped to any metabolic pathway in KEGG.
No functional classes assigned to this gene.
Modbase 3D models: Rv0009
PDB structures: 1W74
Upregulation ranking: this gene ranks in the lower 20-40% group of genes. Shows this level of upregulation in: Dormant phase.
Upregulation ranking: this gene ranks in the lower 0-20% group of genes. Shows this level of upregulation in: Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 10 Cumulative epitope score: 11.0 Normalized epitope score: 6.0 Percentile: 94.0 (this protein belongs to the top 6.0% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL cluster: OG1.2_2741 Number of Paralogs: 1 Arabidopsis thaliana At3g44600.1 | OrthoMCL Brugia malayi Bm1_28740 | OrthoMCL Caenorhabditis elegans Y87G2A.6 | OrthoMCL Drosophila melanogaster CG3511-PA | OrthoMCL Homo sapiens ENSP00000261308 | OrthoMCL Mycobacterium leprae strain TN ML0492 | OrthoMCL Mycobacterium leprae strain TN ML0011 | OrthoMCL Mus musculus ENSMUSP00000022226 | OrthoMCL Mycobacterium tuberculosis Rv0009 (this record). | OrthoMCL P. falciparum 3D7 PFE0505w | OrthoMCL Plasmodium vivax Pv098070 | OrthoMCL Schistosoma mansoni Smp_133820 | OrthoMCL Toxoplasma gondii 641.m01591 | OrthoMCL
[+/–] Show essentiality data references.
No manually curated information for this target.
Mean compound desirability (max is 1): Mean number of compounds:
Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.
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4 chemical compounds are associated with this gene.
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Assay information
Assay: Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ); Source: Sigma-Aldrich Description: Automatic link to known assays based on EC numbers.
Reagent availability
No reagent availability information for this target.
User: ()
Gene identifier: Rv0009 Mycobacterium tuberculosis, PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A)
4 literature references were collected for this gene.
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