Detailed view for Rv0016c

Basic information

TDR Targets ID: 6648
Mycobacterium tuberculosis, PROBABLE PENICILLIN-BINDING PROTEIN PBPA

Source Database / ID: TubercuList / Rv0016c

pI: 8.56 | Length (AA): 491 | MW (Da): 51575 | Number of Paralogs: 1 | -.-.-.-

Signal peptide: Y | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1

Pfam domains

PF00905   Transpeptidase

Gene Ontology

Biological Process:
GO:0009273   peptidoglycan-based cell wall biogenesis   [+/–] show term definition

The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall.

Molecular Function:
GO:0008658   penicillin binding   [+/–] show term definition

Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Rv0016c  

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 21
Cumulative epitope score: 23.6
Normalized epitope score: 4.8
Percentile: 52.5 (this protein belongs to the top 47.5% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL cluster: OG1.2_9918
Number of Paralogs: 1
Escherichia coli K12 gi|16128618|ref|NP_415168.1|   |   OrthoMCL
Mycobacterium leprae strain TN ML0018   |   OrthoMCL
Mycobacterium leprae strain TN ML1577   |   OrthoMCL
Mycobacterium tuberculosis Rv0016c (this record).   |   OrthoMCL
Wolbachia endosymbiont of Brugia malayi Wbm0075   |   OrthoMCL

Essentiality Rv0016c has essentiality data
Gene/Ortholog: mtu16 (OG1.2_9918); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco624 (OG1.2_9918); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco624 (OG1.2_9918); Phenotype: essential; Source study: gerdes
Gene/Ortholog: eco624 (OG1.2_9918); Phenotype: essential; Source study: keio
Gene/Ortholog: eco624 (OG1.2_9918); Phenotype: essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes (curated)

No manually curated information for this target.

Druggability

Druggability index (max is 1): 0.5
Mean compound desirability (max is 1):
Mean number of compounds:

Associated compounds

Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.

Do send us a note: if you have information about compounds for this gene.

No chemical compound is associated with this gene.

If you have information about compounds for this gene, please enter them in a user comment (see below) or contact us.

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic references

No literature references are available for this gene.

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User comments

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