Detailed view for Rv0032

Basic information

TDR Targets ID: 5717
Mycobacterium tuberculosis, POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTH

Source Database / ID: Tuberculist / Rv0032 

pI: 7.02 | Length (AA): 771 | MW (Da): 86243 | Number of Paralogs: 1

EC number(s): 2.3.1.47 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00155   Aminotran_1_2

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003824   catalytic activity  
GO:0030170   pyridoxal phosphate binding  

Process: (mouse over links to read term descriptions)

GO:0009058   biosynthetic process  
Metabolic Pathways

Biotin metabolism (KEGG)
Metabolic pathways (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Rv0032  

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 35
Cumulative epitope score: 39.3
Normalized epitope score: 5.1
Percentile: 66.9 (this protein belongs to the top 33.1% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10268
Number of Paralogs: 1

Ortholog group members from selected species:
Arabidopsis thaliana NP_974731   ATBIOF (BIOTIN F); 8-amino-7-oxononanoate synthase/ transam... |   OrthoMCL
Arabidopsis thaliana NP_196082   ATBIOF (BIOTIN F); 8-amino-7-oxononanoate synthase/ transam... |   OrthoMCL
Brugia malayi Bm1_01535   2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial prec... |   OrthoMCL
Caenorhabditis elegans T25B9.1   CE35627 WBGene00012007 glycine C-acetyltransferase status:Pa... |   OrthoMCL
Cryptosporidium neoformas XP_569249   5-aminolevulinate synthase ... |   OrthoMCL
Cryptosporidium neoformas XP_566616   8-amino-7-oxononanoatesynthase ... |   OrthoMCL
Drosophila melanogaster FBpp0072060   |   OrthoMCL
Drosophila melanogaster FBpp0075815   |   OrthoMCL
Escherichia coli K12 NP_418074.1   2-amino-3-ketobutyrate coenzyme A ligase [Escherichia coli K... |   OrthoMCL
Escherichia coli K12 NP_415297.1   8-amino-7-oxononanoate synthase [Escherichia coli K12]... |   OrthoMCL
Homo sapiens ENSP00000332369   |   OrthoMCL
Homo sapiens ENSP00000392725   |   OrthoMCL
Homo sapiens ENSP00000371110   |   OrthoMCL
Mycobacterium leprae strain TN ML1217   PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF (AONS) (8-AMIN... |   OrthoMCL
Mus musculus ENSMUSP00000006544   |   OrthoMCL
Mus musculus ENSMUSP00000108143   |   OrthoMCL
Mus musculus ENSMUSP00000066040   |   OrthoMCL
Mycobacterium tuberculosis Rv1569   PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF1 (AONS) (8-AMI... |   OrthoMCL
Mycobacterium tuberculosis Rv0032 (this record).   POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMI... |   OrthoMCL
Neospora caninum NCLIV_027820   |   OrthoMCL
Oryza sativa NP_001065381   Os10g0560900 ... |   OrthoMCL
Oryza sativa NP_001044174   Os01g0736400 ... |   OrthoMCL
Plasmodium berghei PB000228.01.0   delta-aminolevulinic acid synthetase, putative ... |   OrthoMCL
Plasmodium chabaudi PCAS_146150   delta-aminolevulinic acid synthetase, putative ... |   OrthoMCL
P. falciparum 3D7 PFL2210w   delta-aminolevulinic acid synthetase... |   OrthoMCL
Plasmodium knowlesi PKH_146340   delta-aminolevulinic acid synthethase, putative ... |   OrthoMCL
Plasmodium vivax PVX_101195   5-aminolevulinic acid synthase, putative... |   OrthoMCL
Plasmodium yoelii PY05459   delta-aminolevulinic acid synthetase ... |   OrthoMCL
Saccharomyces cerevisiae YDR232W   HEM1 SGDID:S000002640, Chr IV from 927448-929094, Verified O... |   OrthoMCL
Schistosoma mansoni Smp_045260   5-aminolevulinic acid synthase... |   OrthoMCL
Trypanosoma brucei gambiense Tbg972.8.6090   |   OrthoMCL
Trypanosoma brucei Tb927.8.6060   2-amino-3-ketobutyrate coenzyme A ligase, putative,glycine a... |   OrthoMCL
Trypanosoma congolense TcIL3000.8.5850   |   OrthoMCL
Trypanosoma cruzi Tc00.1047053511899.40   2-amino-3-ketobutyrate coenzyme A ligase, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053511899.10   2-amino-3-ketobutyrate coenzyme A ligase, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053511071.140   2-amino-3-ketobutyrate coenzyme A ligase, putative... |   OrthoMCL
Toxoplasma gondii TGME49_058690   5-aminolevulinic acid synthase, putative... |   OrthoMCL
Trypanosoma vivax TvY486_0805600   |   OrthoMCL
Wolbachia endosymbiont of Brugia malayi Wbm0133   5-aminolevulinate synthase... |   OrthoMCL

Essentiality Rv0032 has essentiality data
Gene/Ortholog: mtu1597 (OG4_10268); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu32 (OG4_10268); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: sce1280 (OG4_10268); Phenotype: inviable; Source study: yeastgenome
Gene/Ortholog: eco747 (OG4_10268); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco747 (OG4_10268); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco747 (OG4_10268); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco747 (OG4_10268); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco3497 (OG4_10268); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco3497 (OG4_10268); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3497 (OG4_10268); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3497 (OG4_10268); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • Species Known druggable target Reference Linked compounds
      Homo sapiens 5-aminolevulinate synthase Show papers show compounds
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    1 literature reference was collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

    Log in to add comments, or register.