Identification and ranking of targets against neglected tropical diseases
TDR Targets ID: 5717 Mycobacterium tuberculosis, POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTH Source Database / ID: TubercuList / Rv0032
pI: 7.02 | Length (AA): 771 | MW (Da): 86243 | Number of Paralogs: 2 | | EC number: 2.3.1.47
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
PF00155 Aminotran_1_2
Biological Process: GO:0009058 biosynthetic process [+/–] show term definition The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes. GO:0006520 amino acid metabolic process [+/–] show term definition The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes.
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Molecular Function: GO:0008483 transaminase activity [+/–] show term definition Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology GO:0030170 pyridoxal phosphate binding [+/–] show term definition Interacting selectively with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology GO:0016769 transferase activity, transferring nitrogenous groups [+/–] show term definition Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology GO:0016829 lyase activity [+/–] show term definition Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Interacting selectively with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Biotin metabolism (KEGG)
No functional classes assigned to this gene.
Modbase 3D models: Rv0032
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the mid 40-60% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 35 Cumulative epitope score: 39.3 Normalized epitope score: 5.1 Percentile: 66.9 (this protein belongs to the top 33.1% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL cluster: OG1.2_304 Number of Paralogs: 2 Arabidopsis thaliana At5g04620.1 | OrthoMCL Arabidopsis thaliana At3g48790.1 | OrthoMCL Arabidopsis thaliana At5g04620.2 | OrthoMCL Brugia malayi Bm1_01535 | OrthoMCL Caenorhabditis elegans T25B9.1 | OrthoMCL Drosophila melanogaster CG10361-PA | OrthoMCL Drosophila melanogaster CG3017-PA | OrthoMCL Escherichia coli K12 gi|16131488|ref|NP_418074.1| | OrthoMCL Escherichia coli K12 gi|16128744|ref|NP_415297.1| | OrthoMCL Homo sapiens ENSP00000332369 | OrthoMCL Homo sapiens ENSP00000337131 | OrthoMCL Homo sapiens ENSP00000309259 | OrthoMCL Homo sapiens ENSP00000248924 | OrthoMCL Mycobacterium leprae strain TN ML1217 | OrthoMCL Mus musculus ENSMUSP00000066040 | OrthoMCL Mus musculus ENSMUSP00000073725 | OrthoMCL Mus musculus ENSMUSP00000006544 | OrthoMCL Mycobacterium tuberculosis Rv1569 | OrthoMCL Mycobacterium tuberculosis Rv0032 (this record). | OrthoMCL P. falciparum 3D7 PFL2210w | OrthoMCL Plasmodium vivax Pv101195 | OrthoMCL Saccharomyces cerevisiae YDR232W | OrthoMCL Schistosoma mansoni Smp_045260 | OrthoMCL Trypanosoma brucei Tb927.8.6060 | OrthoMCL Trypanosoma cruzi Tc00.1047053511899.40 Trypanosoma cruzi Tc00.1047053511899.10 Trypanosoma cruzi Tc00.1047053511071.140 Toxoplasma gondii 55.m00094 | OrthoMCL Wolbachia endosymbiont of Brugia malayi Wbm0133 | OrthoMCL
[+/–] Show essentiality data references.
No manually curated information for this target.
Mean compound desirability (max is 1): Mean number of compounds:
Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.
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3 chemical compounds are associated with this gene.
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Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
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Gene identifier: Rv0032 Mycobacterium tuberculosis, POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTH
1 literature reference was collected for this gene.
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