A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 5717 Mycobacterium tuberculosis, POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTH Source Database / ID: Tuberculist / Rv0032
pI: 7.02 | Length (AA): 771 | MW (Da): 86243 | Number of Paralogs: 1
EC number(s): 2.3.1.47 | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
PF00155 Aminotran_1_2
Function: (mouse over links to read term descriptions)
Process: (mouse over links to read term descriptions)
Biotin metabolism (KEGG) Metabolic pathways (KEGG)
No functional classes assigned to this gene.
Modbase 3D models: Rv0032
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the mid 40-60% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 35 Cumulative epitope score: 39.3 Normalized epitope score: 5.1 Percentile: 66.9 (this protein belongs to the top 33.1% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_10268 Number of Paralogs: 1
Ortholog group members from selected species: Arabidopsis thaliana NP_974731 ATBIOF (BIOTIN F); 8-amino-7-oxononanoate synthase/ transam... | OrthoMCL Arabidopsis thaliana NP_196082 ATBIOF (BIOTIN F); 8-amino-7-oxononanoate synthase/ transam... | OrthoMCL Brugia malayi Bm1_01535 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial prec... | OrthoMCL Caenorhabditis elegans T25B9.1 CE35627 WBGene00012007 glycine C-acetyltransferase status:Pa... | OrthoMCL Cryptosporidium neoformas XP_569249 5-aminolevulinate synthase ... | OrthoMCL Cryptosporidium neoformas XP_566616 8-amino-7-oxononanoatesynthase ... | OrthoMCL Drosophila melanogaster FBpp0072060 | OrthoMCL Drosophila melanogaster FBpp0075815 | OrthoMCL Escherichia coli K12 NP_418074.1 2-amino-3-ketobutyrate coenzyme A ligase [Escherichia coli K... | OrthoMCL Escherichia coli K12 NP_415297.1 8-amino-7-oxononanoate synthase [Escherichia coli K12]... | OrthoMCL Homo sapiens ENSP00000332369 | OrthoMCL Homo sapiens ENSP00000392725 | OrthoMCL Homo sapiens ENSP00000371110 | OrthoMCL Mycobacterium leprae strain TN ML1217 PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF (AONS) (8-AMIN... | OrthoMCL Mus musculus ENSMUSP00000006544 | OrthoMCL Mus musculus ENSMUSP00000108143 | OrthoMCL Mus musculus ENSMUSP00000066040 | OrthoMCL Mycobacterium tuberculosis Rv1569 PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF1 (AONS) (8-AMI... | OrthoMCL Mycobacterium tuberculosis Rv0032 (this record). POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMI... | OrthoMCL Neospora caninum NCLIV_027820 | OrthoMCL Oryza sativa NP_001065381 Os10g0560900 ... | OrthoMCL Oryza sativa NP_001044174 Os01g0736400 ... | OrthoMCL Plasmodium berghei PB000228.01.0 delta-aminolevulinic acid synthetase, putative ... | OrthoMCL Plasmodium chabaudi PCAS_146150 delta-aminolevulinic acid synthetase, putative ... | OrthoMCL P. falciparum 3D7 PFL2210w delta-aminolevulinic acid synthetase... | OrthoMCL Plasmodium knowlesi PKH_146340 delta-aminolevulinic acid synthethase, putative ... | OrthoMCL Plasmodium vivax PVX_101195 5-aminolevulinic acid synthase, putative... | OrthoMCL Plasmodium yoelii PY05459 delta-aminolevulinic acid synthetase ... | OrthoMCL Saccharomyces cerevisiae YDR232W HEM1 SGDID:S000002640, Chr IV from 927448-929094, Verified O... | OrthoMCL Schistosoma mansoni Smp_045260 5-aminolevulinic acid synthase... | OrthoMCL Trypanosoma brucei gambiense Tbg972.8.6090 | OrthoMCL Trypanosoma brucei Tb927.8.6060 2-amino-3-ketobutyrate coenzyme A ligase, putative,glycine a... | OrthoMCL Trypanosoma congolense TcIL3000.8.5850 | OrthoMCL Trypanosoma cruzi Tc00.1047053511899.40 2-amino-3-ketobutyrate coenzyme A ligase, putative... | OrthoMCL Trypanosoma cruzi Tc00.1047053511899.10 2-amino-3-ketobutyrate coenzyme A ligase, putative... | OrthoMCL Trypanosoma cruzi Tc00.1047053511071.140 2-amino-3-ketobutyrate coenzyme A ligase, putative... | OrthoMCL Toxoplasma gondii TGME49_058690 5-aminolevulinic acid synthase, putative... | OrthoMCL Trypanosoma vivax TvY486_0805600 | OrthoMCL Wolbachia endosymbiont of Brugia malayi Wbm0133 5-aminolevulinate synthase... | OrthoMCL
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We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
Curated from literature
No chemical compounds is associated to this gene
Predicted associations
By orthology to known druggable targets
By sequence similarity to non orthologous druggable targets
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
User: ()
Gene identifier: Rv0032 Mycobacterium tuberculosis, POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTH
1 literature reference was collected for this gene.
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