A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 6012 Mycobacterium tuberculosis, PROBABLE FATTY-ACID-CoA LIGASE FADD34 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Source Database / ID: Tuberculist / Rv0035
pI: 6.47 | Length (AA): 562 | MW (Da): 60961 | Number of Paralogs: -1
EC number(s): 6.2.1.- | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
PF00501 AMP-binding
Function: (mouse over links to read term descriptions)
Process: (mouse over links to read term descriptions)
This gene is not mapped to any metabolic pathway in KEGG.
No functional classes assigned to this gene.
Modbase 3D models: Rv0035
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the lower 20-40% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 23 Cumulative epitope score: 25.8 Normalized epitope score: 4.6 Percentile: 42.3 (this protein belongs to the top 57.7% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
This protein does not belong to any OrthoMCL cluster.
No essentiality data collected for this gene and/or its orthologs.
We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
Curated from literature
No chemical compounds is associated to this gene
Predicted associations
By orthology to known druggable targets
By sequence similarity to non orthologous druggable targets
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
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Gene identifier: Rv0035 Mycobacterium tuberculosis, PROBABLE FATTY-ACID-CoA LIGASE FADD34 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)
12 literature references were collected for this gene.
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