pI: 4.3015 |
Length (AA): 130 |
MW (Da): 13440 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 130 | 1rqu (A) | 1 | 120 | 50.00 | 0 | 1 | 1.43482 | 0.8 |
4 | 130 | 1dd3 (A) | 1 | 128 | 57.00 | 0 | 1 | 1.57812 | 0.2 |
58 | 130 | 2zjq (5) | 52 | 122 | 58.00 | 0.00000000062 | 1 | 1.28174 | -0.69 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase, Dormant phase. | hasan murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_126884)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G27840 | 50S ribosomal protein L12-2 |
Arabidopsis thaliana | AT1G70190 | ribosomal protein L7/L12 domain-containing protein |
Arabidopsis thaliana | AT4G36420 | ribosomal protein L12 family protein |
Arabidopsis thaliana | AT3G27850 | 50S ribosomal protein L12-3 |
Arabidopsis thaliana | AT3G27830 | 50S ribosomal protein L12-1 |
Arabidopsis thaliana | AT4G37660 | ribosomal protein L12/ ATP-dependent Clp protease adaptor protein |
Babesia bovis | BBOV_IV003600 | ribosomal protein L7/L12 |
Babesia bovis | BBOV_III003310 | hypothetical protein |
Brugia malayi | Bm1_20670 | 60S ribosomal protein L12, mitochondrial precursor, putative |
Candida albicans | CaO19.2275 | likely mitochondrial ribosomal large subunit protein similar to S. cerevisiae YGL068W (E. coli L7/L12) |
Candida albicans | CaO19.9815 | likely mitochondrial ribosomal large subunit protein similar to S. cerevisiae YGL068W (E. coli L7/L12) |
Caenorhabditis elegans | CELE_W09D10.3 | Protein MRPL-12 |
Chlamydia trachomatis | CT_316 | 50S ribosomal protein L7/L12 |
Dictyostelium discoideum | DDB_G0274407 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5012 | mitochondrial ribosomal protein L12 |
Escherichia coli | b3986 | 50S ribosomal subunit protein L7/L12 |
Echinococcus granulosus | EgrG_000891700 | 39S ribosomal protein L12 mitochondrial |
Echinococcus multilocularis | EmuJ_000891700 | 39S ribosomal protein L12, mitochondrial |
Homo sapiens | ENSG00000262814 | mitochondrial ribosomal protein L12 |
Leishmania braziliensis | LbrM.31.3210 | ribosomal protein l7/l12-like protein |
Leishmania braziliensis | LbrM.14.0150 | 60S ribosomal protein, putative |
Leishmania donovani | LdBPK_140150.1 | 60S ribosomal protein, putative |
Leishmania donovani | LdBPK_312950.1 | ribosomal protein l7/l12-like protein |
Leishmania infantum | LinJ.14.0150 | 60S ribosomal protein, putative |
Leishmania infantum | LinJ.31.2950 | ribosomal protein l7/l12-like protein |
Leishmania major | LmjF.31.2850 | ribosomal protein l7/l12-like protein |
Leishmania major | LmjF.14.0150 | 60S ribosomal protein, putative |
Leishmania mexicana | LmxM.14.0150 | 60S ribosomal protein, putative |
Leishmania mexicana | LmxM.30.2850 | ribosomal protein l7/l12-like protein |
Mycobacterium leprae | ML1895c | PROBABLE 50S RIBOSOMAL PROTEIN L7/L12 RPLL (SA1) |
Mus musculus | 56282 | mitochondrial ribosomal protein L12 |
Mycobacterium tuberculosis | Rv0652 | 50S ribosomal protein L7/L12 RplL (SA1) |
Mycobacterium ulcerans | MUL_0742 | 50S ribosomal protein L7/L12 |
Neospora caninum | NCLIV_066990 | hypothetical protein |
Oryza sativa | 9271252 | Os01g0662200 |
Oryza sativa | 4339552 | Os05g0554100 |
Oryza sativa | 4343966 | Os07g0626100 |
Oryza sativa | 4334016 | Os03g0734400 |
Oryza sativa | 4339648 | Os05g0568300 |
Plasmodium berghei | PBANKA_0309000 | mitochondrial ribosomal protein L12 precursor, putative |
Plasmodium berghei | PBANKA_1239400 | 50S ribosomal protein L12, apicoplast, putative |
Plasmodium falciparum | PF3D7_0212200 | mitochondrial ribosomal protein L12 precursor, putative |
Plasmodium falciparum | PF3D7_0524600 | 50S ribosomal protein L12, apicoplast, putative |
Plasmodium knowlesi | PKNH_0409000 | ribosomal protein L7/L12, putative |
Plasmodium knowlesi | PKNH_1008300 | 50S ribosomal protein L12, apicoplast, putative |
Plasmodium vivax | PVX_002920 | 50S ribosomal protein L7/L12, putative |
Plasmodium vivax | PVX_080020 | 50S ribosomal protein L12, apicoplast, putative |
Plasmodium yoelii | PY03559 | ribosomal protein L7/L12 |
Saccharomyces cerevisiae | YGL068W | mitochondrial nucleoid protein MNP1 |
Schistosoma japonicum | Sjp_0005850 | 39S ribosomal protein L12, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_066740 | mitochondrial 60S ribosomal protein L7/L12 |
Schmidtea mediterranea | mk4.000210.00 | |
Trypanosoma brucei gambiense | Tbg972.7.5150 | 60S ribosomal protein, putative |
Trypanosoma brucei gambiense | Tbg972.4.5360 | ribosomal protein L7/L12, putative |
Trypanosoma brucei | Tb927.4.5170 | ribosomal protein L7/L12, putative |
Trypanosoma brucei | Tb927.7.4550 | Mitochondrial ribosomal protein L7/L12 |
Trypanosoma congolense | TcIL3000_7_3780 | 60S ribosomal protein-like, putative |
Trypanosoma congolense | TcIL3000_8_7310 | ribosomal protein L7/L12, putative |
Trypanosoma congolense | TcIL3000_0_46970 | ribosomal protein L7/L12, putative |
Trypanosoma congolense | TcIL3000_0_18300 | ribosomal protein L7/L12, putative |
Trypanosoma cruzi | TcCLB.506605.150 | 60S ribosomal protein, putative |
Trypanosoma cruzi | TcCLB.506419.10 | ribosomal protein L7/L12, putative |
Trypanosoma cruzi | TcCLB.511239.140 | 60S ribosomal protein, putative |
Toxoplasma gondii | TGME49_251950 | ribosomal protein l7/l12 c-terminal domain-containing protein |
Toxoplasma gondii | TGME49_289230 | 50S ribosomal protein L12, putative |
Treponema pallidum | TP0240 | 50S ribosomal protein L7/L12 |
Theileria parva | TP03_0328 | hypothetical protein |
Theileria parva | TP02_0775 | 60S ribosomal protein L7/L12, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0648 | 50S ribosomal protein L7/L12 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu664 this record | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.4.5170 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.5170 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.5170 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.5170 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.7.4550 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4550 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4550 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.7.4550 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3986 | Escherichia coli | essential | goodall |
CELE_W09D10.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W09D10.3 | Caenorhabditis elegans | slow growth | wormbase |
YGL068W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_251950 | Toxoplasma gondii | Probably essential | sidik |
TGME49_289230 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.