pI: 10.8484 |
Length (AA): 220 |
MW (Da): 22888 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 181 | 4kzy (C) | 42 | 235 | 25.00 | 0 | 1 | 1.03445 | 0.06 |
36 | 179 | 1pkp (A) | 5 | 148 | 60.00 | 0 | 1 | 1.39505 | -0.62 |
41 | 189 | 2vqe (E) | 5 | 153 | 49.00 | 0 | 1 | 1.27677 | -0.31 |
127 | 205 | 5xny (A) | 36 | 121 | 39.00 | 0.62 | 0.19 | 0.612091 | 0.68 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | murphy |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | hasan |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_126722)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G57490 | 40S ribosomal protein S2-4 |
Arabidopsis thaliana | AT1G58684 | 40S ribosomal protein S2-2 |
Arabidopsis thaliana | AT1G58983 | 40S ribosomal protein S2-2 |
Arabidopsis thaliana | AT2G41840 | 40S ribosomal protein S2-3 |
Arabidopsis thaliana | AT1G58380 | 40S ribosomal protein S2-1 |
Arabidopsis thaliana | AT1G59359 | 40S ribosomal protein S2-2 |
Arabidopsis thaliana | AT2G33800 | 30S ribosomal protein S5 |
Babesia bovis | BBOV_IV003540 | ribosomal protein S2 |
Brugia malayi | Bm1_39350 | 40S ribosomal protein S2 |
Candida albicans | CaO19.10845 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS2 (YGL123W) small subunit protein S2 |
Candida albicans | CaO19.3334 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS2 (YGL123W) small subunit protein S2 |
Caenorhabditis elegans | CELE_C49H3.11 | Protein RPS-2 |
Cryptosporidium hominis | Chro.40460 | ribosomal protein S5 |
Cryptosporidium parvum | cgd4_4020 | 40S ribosomal protein S2/S5. DSRBD RNA binding domain |
Chlamydia trachomatis | CT_512 | 30S ribosomal protein S5 |
Dictyostelium discoideum | DDB_G0293742 | ribosomal protein S2 |
Dictyostelium discoideum | DDB_G0293090 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5920 | Ribosomal protein S2 |
Escherichia coli | b3303 | 30S ribosomal subunit protein S5 |
Echinococcus granulosus | EgrG_000726300 | 40S ribosomal protein S2 |
Entamoeba histolytica | EHI_020280 | 40S ribosomal protein S2, putative |
Echinococcus multilocularis | EmuJ_000726300 | 40S ribosomal protein S2 |
Giardia lamblia | GL50803_8118 | Ribosomal protein S2 |
Homo sapiens | ENSG00000140988 | ribosomal protein S2 |
Leishmania braziliensis | LbrM.19.0370 | 40S ribosomal protein S2 |
Leishmania braziliensis | LbrM.32.0520 | 40S ribosomal protein S2 |
Leishmania donovani | LdBPK_320460.1 | 40S ribosomal protein S2 |
Leishmania infantum | LinJ.19.0050 | 40S ribosomal protein S2 |
Leishmania infantum | LinJ.32.0460 | 40S ribosomal protein S2 |
Leishmania major | LmjF.19.0060 | 40S ribosomal protein S2 |
Leishmania major | LmjF.32.0450 | 40S ribosomal protein S2 |
Leishmania mexicana | LmxM.31.0450 | 40S ribosomal protein S2 |
Leishmania mexicana | LmxM.19.0060 | 40S ribosomal protein S2 |
Loa Loa (eye worm) | LOAG_02798 | 40S ribosomal protein S2 |
Mycobacterium leprae | ML1842c | PROBABLE 30S RIBOSOMAL PROTEIN S5 RPSE |
Mus musculus | 639606 | predicted gene 10420 |
Mus musculus | 102642415 | 40S ribosomal protein S2-like |
Mus musculus | 620248 | predicted gene 6139 |
Mus musculus | ENSMUSG00000044533 | ribosomal protein S2 |
Mycobacterium tuberculosis | Rv0721 | 30S ribosomal protein S5 RpsE |
Mycobacterium ulcerans | MUL_0811 | 30S ribosomal protein S5 |
Neospora caninum | NCLIV_044000 | hypothetical protein |
Oryza sativa | 4334512 | Os03g0807800 |
Oryza sativa | 4342695 | Os07g0207400 |
Oryza sativa | 4333233 | Os03g0452300 |
Plasmodium berghei | PBANKA_1310800 | 40S ribosomal protein S5, putative |
Plasmodium falciparum | PF3D7_1447000 | 40S ribosomal protein S5 |
Plasmodium knowlesi | PKNH_1235200 | 40S ribosomal protein S5, putative |
Plasmodium vivax | PVX_118145 | 40S ribosomal protein S5, putative |
Plasmodium yoelii | PY06704 | ribosomal protein S5 |
Saccharomyces cerevisiae | YGL123W | ribosomal 40S subunit protein S2 |
Schistosoma japonicum | Sjp_0304520 | ko:K02981 small subunit ribosomal protein S2e, putative |
Schistosoma mansoni | Smp_013470.1 | ribosomal protein S2 |
Schistosoma mansoni | Smp_013470.2 | ribosomal protein S2 |
Schmidtea mediterranea | mk4.091311.04 | |
Schmidtea mediterranea | mk4.012968.03 | 40S ribosomal protein S2 |
Trypanosoma brucei gambiense | Tbg972.10.17870 | RPS2,40S ribosomal protein S2, putative |
Trypanosoma brucei gambiense | Tbg972.10.17750 | 40S ribosomal protein S2, putative |
Trypanosoma brucei | Tb927.10.14710 | 40S ribosomal protein S2, putative |
Trypanosoma brucei | Tb927.10.14600 | 40S ribosomal protein S2, putative |
Trypanosoma congolense | TcIL3000_10_12580 | 40S ribosomal protein S2, putative |
Trypanosoma congolense | TcIL3000_10_12490 | 40S ribosomal protein S2, putative |
Trypanosoma cruzi | TcCLB.506213.60 | 40S ribosomal protein S2, putative |
Trypanosoma cruzi | TcCLB.511287.120 | 40S ribosomal protein S2, putative |
Trypanosoma cruzi | TcCLB.511287.40 | 40S ribosomal protein S2, putative |
Trypanosoma cruzi | TcCLB.503833.40 | 40S ribosomal protein S2, putative |
Toxoplasma gondii | TGME49_305520 | ribosomal protein RPS2 |
Treponema pallidum | TP0206 | 30S ribosomal protein S5 |
Theileria parva | TP02_0780 | 40S ribosomal protein S2, putative |
Trichomonas vaginalis | TVAG_162680 | 40S ribosomal protein S2, putative |
Trichomonas vaginalis | TVAG_142440 | 40S ribosomal protein S2, putative |
Trichomonas vaginalis | TVAG_198100 | 40S ribosomal protein S2, putative |
Trichomonas vaginalis | TVAG_483090 | 40S ribosomal protein S2, putative |
Trichomonas vaginalis | TVAG_359120 | ribosomal S subunit, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0324 | 30S ribosomal protein S5 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu733 this record | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.10.14600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14600 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14600 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3303 | Escherichia coli | essential | goodall |
CELE_C49H3.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C49H3.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C49H3.11 | Caenorhabditis elegans | sterile | wormbase |
YGL123W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1310800 | Plasmodium berghei | Essential | plasmo |
TGME49_305520 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.