Detailed view for Rv1032c

Basic information

TDR Targets ID: 9979
Mycobacterium tuberculosis, TWO COMPONENT SENSOR HISTIDINE KINASE TRCS

Source Database / ID: Tuberculist / Rv1032c 

pI: 5.56 | Length (AA): 509 | MW (Da): 54591 | Number of Paralogs: 3

EC number(s): 2.7.13.3 | Enzyme, KEGG, Brenda (mouse over to display more information)
2.7.3.- | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: Y | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 2

Pfam domains

PF00512   HisKA
PF00672   HAMP

Gene Ontology

Component: (mouse over links to read term descriptions)

GO:0016021   integral to membrane  
GO:0016020   membrane  

Function: (mouse over links to read term descriptions)

GO:0004673   protein histidine kinase activity  
GO:0000155   two-component sensor activity  
GO:0005524   ATP binding  
GO:0004871   signal transducer activity  

Process: (mouse over links to read term descriptions)

GO:0018106   peptidyl-histidine phosphorylation  
GO:0016310   phosphorylation  
GO:0007165   signal transduction  
Metabolic Pathways

Two-component system (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 23
Cumulative epitope score: 26.0
Normalized epitope score: 5.1
Percentile: 67.5 (this protein belongs to the top 32.5% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_52152
Number of Paralogs: 3

Ortholog group members from selected species:
Mycobacterium tuberculosis Rv1032c (this record).   TWO COMPONENT SENSOR HISTIDINE KINASE TRCS... |   OrthoMCL

Essentiality Rv1032c has essentiality data
Gene/Ortholog: mtu1049 (OG4_52152); Phenotype: non-essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    21 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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