Detailed view for Rv1079

Basic information

TDR Targets ID: 6453
Mycobacterium tuberculosis, PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)

Source Database / ID: Tuberculist / Rv1079 

pI: 5.0957 | Length (AA): 388 | MW (Da): 40982 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF01053   Cys/Met metabolism PLP-dependent enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0003824   catalytic activity  
GO:0006520   amino acid metabolic process  

Network

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the lower 0-20% group of genes. Dormant phase, Dormant phase.
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_126775)
Species Accession Gene Product
Arabidopsis thaliana AT3G57050   cystathionine beta-lyase
Arabidopsis thaliana AT3G01120   cystathionine gamma-synthase
Brugia malayi Bm1_05320   cystathionine gamma-lyase
Candida albicans CaO19.6402   cystathionine gamma-lyase
Candida albicans CaO19.13760   cystathionine gamma-lyase
Candida albicans CaO19.2092   cystathionine beta-lyase
Candida albicans CaO19.9639   cystathionine beta-lyase
Caenorhabditis elegans CELE_C12C8.2   Protein CBL-1, isoform A
Caenorhabditis elegans CELE_F22B8.6   Protein CTH-1, isoform B
Caenorhabditis elegans CELE_ZK1127.10   Protein CTH-2
Dictyostelium discoideum DDB_G0269122   cystathionine gamma-lyase
Drosophila melanogaster Dmel_CG5345   CG5345 gene product from transcript CG5345-RB
Escherichia coli b3939   cystathionine gamma-synthase, PLP-dependent
Entamoeba histolytica EHI_144610   methionine gamma-lyase
Entamoeba histolytica EHI_057550   methionine gamma-lyase, putative
Homo sapiens ENSG00000116761   cystathionine gamma-lyase
Leishmania braziliensis LbrM.14.0470   cystathionine beta-lyase-like protein
Leishmania braziliensis LbrM.34.3140   cystathione gamma lyase, putative
Leishmania donovani LdBPK_353280.1   cystathione gamma lyase, putative
Leishmania donovani LdBPK_140470.1   cystathionine beta-lyase-like protein
Leishmania infantum LinJ.35.3280   cystathione gamma lyase, putative
Leishmania infantum LinJ.14.0470   cystathionine beta-lyase-like protein
Leishmania major LmjF.14.0460   cystathionine beta-lyase-like protein
Leishmania major LmjF.35.3230   cystathione gamma lyase, putative
Leishmania mexicana LmxM.34.3230   cystathione gamma lyase, putative
Leishmania mexicana LmxM.14.0460   cystathionine beta-lyase-like protein
Loa Loa (eye worm) LOAG_10544   cystathionine gamma-lyase
Mycobacterium leprae ML2394   Cystathionine gamma-synthase
Mus musculus ENSMUSG00000028179   cystathionase (cystathionine gamma-lyase)
Mycobacterium tuberculosis Rv1079 this record   PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)
Mycobacterium tuberculosis Rv0391   PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ (OSH SULFHYDRYLASE)
Mycobacterium ulcerans MUL_0201   cystathionine gamma-synthase
Neospora caninum NCLIV_056280   Cys/Met metabolism PLP-dependent enzyme, related
Oryza sativa 4340283   Os06g0175800
Oryza sativa 4348560   Os10g0399200
Oryza sativa 4348561   Os10g0399700
Oryza sativa 4332956   Os03g0376100
Saccharomyces cerevisiae YAL012W   cystathionine gamma-lyase CYS3
Saccharomyces cerevisiae YGL184C   cystathionine beta-lyase STR3
Schistosoma japonicum Sjp_0302890   ko:K01758 cystathionine gamma-lyase [EC4.4.1.1], putative
Schistosoma mansoni Smp_083650   cystathionine beta-lyase
Schmidtea mediterranea mk4.085557.00  
Schmidtea mediterranea mk4.003643.00   Cystathionine gamma-lyase
Schmidtea mediterranea mk4.018765.00  
Schmidtea mediterranea mk4.003986.01   Cystathionine gamma-lyase
Trypanosoma brucei gambiense Tbg972.9.7510   cystathione gamma lyase, putative
Trypanosoma brucei Tb927.9.12320   cystathione gamma lyase, putative
Trypanosoma brucei Tb11.v5.0869   cystathione gamma lyase, putative
Trypanosoma congolense TcIL3000_9_5100   cystathione gamma lyase, putative
Trypanosoma congolense TcIL3000_0_07510   cystathione gamma lyase, putative
Trypanosoma cruzi TcCLB.510661.250   cystathione gamma lyase, putative
Trypanosoma cruzi TcCLB.510741.10   cystathione gamma lyase, putative
Toxoplasma gondii TGME49_312930   cystathione gamma lyase, putative
Trichomonas vaginalis TVAG_147790   cysteine/methionine metabolism pyridoxal-5-phosphate enzymes, putative
Trichomonas vaginalis TVAG_041600   cystathionine beta-lyase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0493   cystathionine beta-lyase

Essentiality

Rv1079 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1096 this record Mycobacterium tuberculosis non-essential nmpdr
mtu394 Mycobacterium tuberculosis non-essential nmpdr
b3939 Escherichia coli non-essential goodall
CELE_ZK1127.10 Caenorhabditis elegans larval lethal wormbase
YAL012W Saccharomyces cerevisiae inviable yeastgenome

Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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User comments

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Gene identifier Rv1079 (Mycobacterium tuberculosis), PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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