Detailed view for Rv1079

Basic information

TDR Targets ID: 6453
Mycobacterium tuberculosis, PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)

Source Database / ID: Tuberculist / Rv1079 

pI: 5.1 | Length (AA): 388 | MW (Da): 40982 | Number of Paralogs: 2

EC number(s): 2.5.1.48 | Enzyme, KEGG, Brenda (mouse over to display more information)
4.2.99.9 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0030170   pyridoxal phosphate binding  
GO:0003824   catalytic activity  

Process: (mouse over links to read term descriptions)

GO:0006520   amino acid metabolic process  
Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 19
Cumulative epitope score: 21.0
Normalized epitope score: 5.4
Percentile: 80.8 (this protein belongs to the top 19.2% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10237
Number of Paralogs: 2

Ortholog group members from selected species:
Arabidopsis thaliana NP_191264   CBL (cystathionine beta-lyase); cystathionine beta-lyase ... |   OrthoMCL
Arabidopsis thaliana NP_850712   CBL (cystathionine beta-lyase); cystathionine beta-lyase ... |   OrthoMCL
Arabidopsis thaliana NP_186761   MTO1 (METHIONINE OVERACCUMULATION 1); cystathionine gamma-s... |   OrthoMCL
Arabidopsis thaliana NP_850713   CBL (cystathionine beta-lyase); cystathionine beta-lyase ... |   OrthoMCL
Brugia malayi Bm1_05320   cystathionine gamma-lyase, putative... |   OrthoMCL
Caenorhabditis elegans F22B8.6   CE15884 WBGene00009048 cystathione gamma-lyase like status:C... |   OrthoMCL
Caenorhabditis elegans C12C8.2   CE36100 WBGene00007533 L-methionine-alpha-deamino-gamma-merc... |   OrthoMCL
Caenorhabditis elegans ZK1127.10   CE07648 WBGene00022856 cystathionine gamma-lyase status:Conf... |   OrthoMCL
Cryptosporidium neoformas XP_567850   cystathionine beta-lyase ... |   OrthoMCL
Cryptosporidium neoformas XP_567851   cystathionine beta-lyase ... |   OrthoMCL
Cryptosporidium neoformas XP_568668   cystathionine gamma-lyase ... |   OrthoMCL
Drosophila melanogaster FBpp0085889   |   OrthoMCL
Escherichia coli K12 NP_418374.1   cystathionine gamma-synthase [Escherichia coli K12]... |   OrthoMCL
Homo sapiens ENSP00000359976   |   OrthoMCL
Leishmania braziliensis LbrM14_V2.0470   |   OrthoMCL
Leishmania braziliensis LbrM34_V2.3140   |   OrthoMCL
Leishmania infantum LinJ35_V3.3280   |   OrthoMCL
Leishmania infantum LinJ14_V3.0470   |   OrthoMCL
Leishmania major LmjF14.0460   cystathionine beta-lyase-like protein... |   OrthoMCL
Leishmania major LmjF35.3230   cystathione gamma lyase, putative... |   OrthoMCL
Leishmania mexicana LmxM34.3230   |   OrthoMCL
Leishmania mexicana LmxM14.0460   |   OrthoMCL
Mycobacterium leprae strain TN ML0275c   Probable O-succinylhomoserine sulfhydrylase MetZ (osh sulfhy... |   OrthoMCL
Mycobacterium leprae strain TN ML2394c   PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYL... |   OrthoMCL
Mus musculus ENSMUSP00000113672   |   OrthoMCL
Mycobacterium tuberculosis Rv1079 (this record).   PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYL... |   OrthoMCL
Mycobacterium tuberculosis Rv0391   PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ (OSH SULFHY... |   OrthoMCL
Neospora caninum NCLIV_056280   |   OrthoMCL
Oryza sativa NP_001064540   Os10g0399700 ... |   OrthoMCL
Oryza sativa NP_001050220   Os03g0376100 ... |   OrthoMCL
Oryza sativa NP_001056951   Os06g0175800 ... |   OrthoMCL
Oryza sativa NP_001064539   Os10g0399200 ... |   OrthoMCL
Saccharomyces cerevisiae YGL184C   STR3 SGDID:S000003152, Chr VII from 156018-154621, reverse c... |   OrthoMCL
Saccharomyces cerevisiae YAL012W   CYS3 SGDID:S000000010, Chr I from 130802-131986, Verified OR... |   OrthoMCL
Schistosoma mansoni Smp_083650   cystathionine beta-lyase, putative... |   OrthoMCL
Trypanosoma brucei gambiense Tbg972.9.7510   |   OrthoMCL
Trypanosoma brucei Tb09.211.3330   cystathione gamma lyase, putative... |   OrthoMCL
Trypanosoma congolense TcIL3000.9.5100   |   OrthoMCL
Trypanosoma congolense TcIL3000.0.07510   |   OrthoMCL
Trypanosoma cruzi Tc00.1047053510661.250   cystathione gamma lyase, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053510741.10   cystathione gamma lyase, putative... |   OrthoMCL
Toxoplasma gondii TGME49_112930   cystathionine beta-lyase, putative... |   OrthoMCL

Essentiality Rv1079 has essentiality data
Gene/Ortholog: mtu1096 (OG4_10237); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu394 (OG4_10237); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco3796 (OG4_10237); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco3796 (OG4_10237); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3796 (OG4_10237); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3796 (OG4_10237); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: Tb09.211.3330 (OG4_10237); Phenotype: no significant loss or gain of fitness in bloodstream forms (3 days); Source study: alsford
Gene/Ortholog: Tb09.211.3330 (OG4_10237); Phenotype: no significant loss or gain of fitness in bloodstream forms (6 days); Source study: alsford
Gene/Ortholog: Tb09.211.3330 (OG4_10237); Phenotype: no significant loss or gain of fitness in procyclic forms; Source study: alsford
Gene/Ortholog: Tb09.211.3330 (OG4_10237); Phenotype: no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms; Source study: alsford

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    1 literature reference was collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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