Detailed view for Rv1266c

Basic information

TDR Targets ID: 6800
Mycobacterium tuberculosis, PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKNH (PROTEIN KINASE H) (STPK H)

Source Database / ID: Tuberculist / Rv1266c 

pI: 6.74 | Length (AA): 626 | MW (Da): 66754 | Number of Paralogs: 6

EC number(s): 2.7.1.- | Enzyme, KEGG, Brenda (mouse over to display more information)
2.7.11.1 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1

Pfam domains

PF00069   Pkinase

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  

Process: (mouse over links to read term descriptions)

GO:0006468   protein amino acid phosphorylation  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 24
Cumulative epitope score: 26.9
Normalized epitope score: 4.3
Percentile: 29.5 (this protein belongs to the top 70.5% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_23912
Number of Paralogs: 6

Ortholog group members from selected species:
Giardia intestinalis GL50581_1642   Kinase, NEK ... |   OrthoMCL
Giardia intestinalis GL50581_868   Kinase, NEK ... |   OrthoMCL
Giardia lamblia GLP15_3141   Kinase, NEK ... |   OrthoMCL
Giardia lamblia GLP15_1780   Kinase, NEK ... |   OrthoMCL
Mycobacterium tuberculosis Rv1743   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE E PKN... |   OrthoMCL
Mycobacterium tuberculosis Rv1266c (this record).   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKN... |   OrthoMCL
Mycobacterium tuberculosis Rv2914c   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKN... |   OrthoMCL
Mycobacterium tuberculosis Rv2088   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE J PKN... |   OrthoMCL

Essentiality Rv1266c has essentiality data
Gene/Ortholog: mtu1773 (OG4_23912); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1287 (OG4_23912); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2961 (OG4_23912); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2121 (OG4_23912); Phenotype: non-essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: normal (PATO:0000461) [+/–] show term definition
Evidence: inferred from animal model system (ECO:0000179)
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-21.
PubMed References: 16077122

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: normal (PATO:0000461) [+/–] show term definition
Evidence: inferred from in vitro culture assay (ECO:0000182) [+/–] show term definition
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-21.
PubMed References: 16077122

Affected entity: catalytic activity (GO:0003824) [+/–] show term definition

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Synonym: enzyme activity

Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition
Occurs in (anatomic term): in vitro (MI:0492) [+/–] show term definition
Evidence: inferred from specific protein inhibition (ECO:0000020)
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: 34576   55244   132331   161165   568050   574748   574749  
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-21.
PubMed References: 15043876

No validation aspects annotated for this target.

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

  • Curated from literature

    7 chemical compounds are associated with this gene

    Compound Source Reference
    C14H17N3O2S Curated by TDRTargets Show papers
    C28H26N4O3 Curated by TDRTargets Show papers
    C28H26N4O3 Curated by TDRTargets Show papers
    C28H26N4O3 Curated by TDRTargets Show papers
    C28H26N4O3 Curated by TDRTargets Show papers
    C28H26N4O3 Curated by TDRTargets Show papers
    C28H27N4O3 Curated by TDRTargets Show papers

  • Predicted associations

  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    81 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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