A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 6800 Mycobacterium tuberculosis, PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKNH (PROTEIN KINASE H) (STPK H) Source Database / ID: Tuberculist / Rv1266c
pI: 6.74 | Length (AA): 626 | MW (Da): 66754 | Number of Paralogs: 6
EC number(s): 2.7.1.- | Enzyme, KEGG, Brenda (mouse over to display more information) 2.7.11.1 | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1
[DGPI v2.04]
PF00069 Pkinase
Function: (mouse over links to read term descriptions)
Process: (mouse over links to read term descriptions)
This gene is not mapped to any metabolic pathway in KEGG.
No functional classes assigned to this gene.
Modbase 3D models: 0 no model available for this protein in Modbase.
[+/–] Help me make sense of these data. Target Beg: first modeled residue Target End: last modeled residue Template: template structure used for modelling (PDB accession and chain) Template Beg: first template residue in target-template alignment Template End: last template residue in target-template alignment Identity: sequence identity Evalue: E value for target-template hit Model Score: GA341 score (>0.7 for reliable model) MPQS: ModPipe Quality Score (>1.1 for reliable model) zDope: zDope Score (negative for reliable model) A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the upper 60-80% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 24 Cumulative epitope score: 26.9 Normalized epitope score: 4.3 Percentile: 29.5 (this protein belongs to the top 70.5% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_23912 Number of Paralogs: 6
Ortholog group members from selected species: Giardia intestinalis GL50581_1642 Kinase, NEK ... | OrthoMCL Giardia intestinalis GL50581_868 Kinase, NEK ... | OrthoMCL Giardia lamblia GLP15_3141 Kinase, NEK ... | OrthoMCL Giardia lamblia GLP15_1780 Kinase, NEK ... | OrthoMCL Mycobacterium tuberculosis Rv1743 PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE E PKN... | OrthoMCL Mycobacterium tuberculosis Rv1266c (this record). PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKN... | OrthoMCL Mycobacterium tuberculosis Rv2914c PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKN... | OrthoMCL Mycobacterium tuberculosis Rv2088 PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE J PKN... | OrthoMCL
[+/–] Show essentiality data references.
Annotated phenotypes:
Affected entity: growth (GO:0040007) [+/–] show term definition The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern Phenotypic quality: normal (PATO:0000461) [+/–] show term definition Synonym: average Evidence: inferred from animal model system (ECO:0000179) Observed in: Mycobacterium tuberculosis (NEWT:1773) Drugs/inhibitors: No drug identifiers listed for this gene. Annotated by: crowther@u.washington.edu. Comment: 2007-12-21. PubMed References: 16077122
The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern
Synonym: average
Affected entity: growth (GO:0040007) [+/–] show term definition The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern Phenotypic quality: normal (PATO:0000461) [+/–] show term definition Synonym: average Evidence: inferred from in vitro culture assay (ECO:0000182) [+/–] show term definition Synonym: ex vivo assay Observed in: Mycobacterium tuberculosis (NEWT:1773) Drugs/inhibitors: No drug identifiers listed for this gene. Annotated by: crowther@u.washington.edu. Comment: 2007-12-21. PubMed References: 16077122
Synonym: ex vivo assay
Affected entity: catalytic activity (GO:0003824) [+/–] show term definition Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Synonym: enzyme activity Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition Synonym: reduced Occurs in (anatomic term): in vitro (MI:0492) [+/–] show term definition Experiments performed with participants removed from the cellular environment e.g. cell extracts, isolated proteins.\nOBSOLETE as a full host organisms description is recommended using tax id == -1 as convention to refer to 'in vitro' interaction. Evidence: inferred from specific protein inhibition (ECO:0000020) Observed in: Mycobacterium tuberculosis (NEWT:1773) Drugs/inhibitors: 34576 55244 132331 161165 568050 574748 574749 Annotated by: crowther@u.washington.edu. Comment: 2007-12-21. PubMed References: 15043876
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Synonym: enzyme activity
Synonym: reduced
Experiments performed with participants removed from the cellular environment e.g. cell extracts, isolated proteins.\nOBSOLETE as a full host organisms description is recommended using tax id == -1 as convention to refer to 'in vitro' interaction.
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started. In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
No validation aspects annotated for this target.
Druggability index (range: 0 to 1): 0.7
Curated from literature
7 chemical compounds are associated with this gene
Predicted associations
By orthology to known druggable targets
From ChEMBL
By sequence similarity to non orthologous druggable targets
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
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Gene identifier: Rv1266c Mycobacterium tuberculosis, PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKNH (PROTEIN KINASE H) (STPK H)
81 literature references were collected for this gene.
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