pI: 4.1833 |
Length (AA): 232 |
MW (Da): 24073 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 220 | 1rpx (A) | 7 | 224 | 44.00 | 0 | 1 | 1.53731 | -1.23 |
10 | 230 | 3ovp (A) | 4 | 224 | 44.00 | 0 | 1 | 1.53809 | -0.86 |
13 | 224 | 2fli (A) | 6 | 219 | 45.00 | 0 | 1 | 1.55529 | -1.02 |
13 | 226 | 1h1y (A) | 8 | 223 | 50.00 | 0 | 1 | 1.54231 | -0.97 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127027)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G63290 | putative D-ribulose-5-phosphate 3-epimerase |
Arabidopsis thaliana | AT5G61410 | D-ribulose-5-phosphate-3-epimerase |
Arabidopsis thaliana | AT3G01850 | ribulose-phosphate 3-epimerase |
Brugia malayi | Bm1_10935 | hypothetical protein |
Candida albicans | CaO19.7108 | D-ribulose-5-Phosphate 3-epimerase |
Candida albicans | CaO19_7108 | hypothetical protein |
Caenorhabditis elegans | CELE_F08F8.7 | Protein F08F8.7 |
Chlamydia trachomatis | CT_121 | ribulose-phosphate 3-epimerase |
Dictyostelium discoideum | DDB_G0278275 | ribulose phosphate 3-epimerase |
Drosophila melanogaster | Dmel_CG30499 | CG30499 gene product from transcript CG30499-RA |
Escherichia coli | b3386 | D-ribulose-5-phosphate 3-epimerase |
Echinococcus granulosus | EgrG_000781900 | ribulose phosphate 3 epimerase |
Entamoeba histolytica | EHI_006900 | ribulose-phosphate 3-epimerase, putative |
Echinococcus multilocularis | EmuJ_000781900 | ribulose phosphate 3 epimerase |
Giardia lamblia | GL50803_10324 | Ribulose-phosphate 3-epimerase |
Homo sapiens | ENSG00000235376 | ribulose-5-phosphate-3-epimerase-like 1 |
Homo sapiens | ENSG00000197713 | ribulose-5-phosphate-3-epimerase |
Leishmania braziliensis | LbrM.33.1830 | ribulose-5-phosphate 3-epimerase, putative |
Leishmania donovani | LdBPK_331660.1 | ribulose-5-phosphate 3-epimerase, putative |
Leishmania infantum | LinJ.33.1660 | ribulose-5-phosphate 3-epimerase, putative |
Leishmania major | LmjF.33.1570 | ribulose-5-phosphate 3-epimerase, putative |
Leishmania mexicana | LmxM.32.1570 | ribulose-5-phosphate 3-epimerase, putative |
Loa Loa (eye worm) | LOAG_05451 | rpe protein |
Mycobacterium leprae | ML0554 | Probable ribulose-phosphate 3-epimerase Rpe |
Mus musculus | ENSMUSG00000026005 | ribulose-5-phosphate-3-epimerase |
Mycobacterium tuberculosis | Rv1408 | Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase) |
Mycobacterium ulcerans | MUL_1804 | ribulose-phosphate 3-epimerase |
Neospora caninum | NCLIV_065340 | hypothetical protein |
Oryza sativa | 4331761 | Os03g0169100 |
Oryza sativa | 4347508 | Os09g0505700 |
Plasmodium berghei | PBANKA_1435100 | ribulose-phosphate 3-epimerase, putative |
Plasmodium falciparum | PF3D7_1219900 | ribulose-phosphate 3-epimerase, putative |
Plasmodium knowlesi | PKNH_1439100 | ribulose-phosphate 3-epimerase, putative |
Plasmodium vivax | PVX_123635 | D-ribulose-5-phosphate 3-epimerase, putative |
Plasmodium yoelii | PY01807 | putative D-ribulose-5-phosphate 3-epimerase |
Saccharomyces cerevisiae | YJL121C | ribulose-phosphate 3-epimerase RPE1 |
Schistosoma japonicum | Sjp_0015540 | ko:K01783 ribulose-phosphate 3-epimerase [EC5.1.3.1], putative |
Schistosoma mansoni | Smp_104580 | ribulose-phosphate 3-epimerase |
Schmidtea mediterranea | mk4.006062.02 | |
Schmidtea mediterranea | mk4.041404.02 | |
Schmidtea mediterranea | mk4.000523.05 | Ribulose-phosphate 3-epimerase |
Trypanosoma brucei gambiense | Tbg972.10.14730 | ribulose-5-phosphate 3-epimerase, putative |
Trypanosoma brucei | Tb927.10.12210 | ribulose-5-phosphate 3-epimerase, putative |
Trypanosoma congolense | TcIL3000_10_10440 | ribulose-5-phosphate 3-epimerase, putative |
Trypanosoma cruzi | TcCLB.510257.30 | ribulose-5-phosphate 3-epimerase, putative |
Trypanosoma cruzi | TcCLB.509213.70 | ribulose-5-phosphate 3-epimerase, putative |
Toxoplasma gondii | TGME49_247670 | ribulose-phosphate 3 epimerase family protein |
Treponema pallidum | TP0945 | ribulose-phosphate 3-epimerase (cfxE) |
Trichomonas vaginalis | TVAG_158280 | ribulose-5-phosphate-3-epimerase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0236 | Pentose-5-phosphate-3-epimerase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.12210 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.12210 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.12210 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.12210 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3386 | Escherichia coli | essential | goodall |
TGME49_247670 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.