Detailed view for Rv2192c

Basic information

TDR Targets ID: 9989
Mycobacterium tuberculosis, Probable anthranilate phosphoribosyltransferase TrpD

Source Database / ID: Tuberculist / Rv2192c 

pI: 6.4033 | Length (AA): 371 | MW (Da): 37708 | Number of Paralogs: 0

EC number(s): 2.4.2.18 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF02885   Glycos_trans_3N

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0004048   anthranilate phosphoribosyltransferase activity  

Process: (mouse over links to read term descriptions)

GO:0000162   tryptophan biosynthetic process  
GO:0008152   metabolic process  
Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: 1ZVW   2BPQ  

Expression

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 13
Cumulative epitope score: 14.7
Normalized epitope score: 4.0
Percentile: 18.5 (this protein belongs to the top 81.5% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_12698
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_197300   TRP1 (tryptophan biosynthesis 1); anthranilate phosphoribos... |   OrthoMCL
Cryptosporidium neoformas XP_567135   anthranilate phosphoribosyltransferase ... |   OrthoMCL
Escherichia coli K12 NP_415779.1   bifunctional indole-3-glycerol-phosphate synthase/anthranila... |   OrthoMCL
Mycobacterium leprae strain TN ML0883   Probable anthranilate phosphoribosyltransferase TrpD... |   OrthoMCL
Mycobacterium tuberculosis Rv2192c (this record).   Probable anthranilate phosphoribosyltransferase TrpD... |   OrthoMCL
Oryza sativa NP_001048822   Os03g0126000 ... |   OrthoMCL
Saccharomyces cerevisiae YDR354W   TRP4 SGDID:S000002762, Chr IV from 1184740-1185882, Verified... |   OrthoMCL

Essentiality Rv2192c has essentiality data
Gene/Ortholog: mtu2226 (OG4_12698); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: eco1226 (OG4_12698); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco1226 (OG4_12698); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco1226 (OG4_12698); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco1226 (OG4_12698); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    1 literature reference was collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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