Detailed view for Rv2234

Basic information

TDR Targets ID: 6952
Mycobacterium tuberculosis, PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPA (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) (LMW PHOSPHATASE)

Source Database / ID: Tuberculist / Rv2234 

pI: 6.5051 | Length (AA): 164 | MW (Da): 17860 | Number of Paralogs: 0

EC number(s): 3.1.3.48 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF01451   LMWPc

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0004725   protein tyrosine phosphatase activity  

Process: (mouse over links to read term descriptions)

GO:0006470   protein amino acid dephosphorylation  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: 1U2P   1U2Q  

Expression

Upregulation ranking: this gene ranks in the upper 80-100% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 8
Cumulative epitope score: 9.0
Normalized epitope score: 5.5
Percentile: 83.6 (this protein belongs to the top 16.4% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10985
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_190048   protein tyrosine phosphatase ... |   OrthoMCL
Brugia malayi Bm1_37740   Low molecular weight phosphotyrosine protein phosphatase con... |   OrthoMCL
Caenorhabditis elegans Y94H6A.7   CE36903 WBGene00022379 status:Partially_confirmed TR:Q9N2W8 ... |   OrthoMCL
Cryptosporidium neoformas XP_569194   low molecular weight phosphotyrosine protein phosphatase ... |   OrthoMCL
Drosophila melanogaster FBpp0099893   |   OrthoMCL
Drosophila melanogaster FBpp0100064   |   OrthoMCL
Drosophila melanogaster FBpp0082309   |   OrthoMCL
Escherichia coli K12 NP_415502.4   phosphotyrosine-protein phosphatase [Escherichia coli K12]... |   OrthoMCL
Escherichia coli K12 NP_416565.1   protein-tyrosine phosphatase [Escherichia coli K12]... |   OrthoMCL
Giardia intestinalis GL50581_1322   Low molecular weight protein-tyrosine-phosphatase ... |   OrthoMCL
Giardia lamblia GLP15_5009   Low molecular weight protein-tyrosine-phosphatase ... |   OrthoMCL
Homo sapiens ENSP00000272067   |   OrthoMCL
Mus musculus ENSMUSP00000106509   |   OrthoMCL
Mycobacterium tuberculosis Rv2234 (this record).   PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPA (PROTEIN-TYROSINE-P... |   OrthoMCL
Oryza sativa NP_001062484   Os08g0557400 ... |   OrthoMCL
Saccharomyces cerevisiae YPR073C   LTP1 SGDID:S000006277, Chr XVI from 692415-691930, reverse c... |   OrthoMCL

Essentiality Rv2234 has essentiality data
Gene/Ortholog: mtu2268 (OG4_10985); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco2000 (OG4_10985); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco2000 (OG4_10985); Phenotype: essential; Source study: gerdes
Gene/Ortholog: eco2000 (OG4_10985); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco2000 (OG4_10985); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    20 chemical compounds are associated with this gene

    Compound Source Reference
    C13H16N2 Curated by TDRTargets Show papers
    C14H17NS Curated by TDRTargets Show papers
    C14H17NS Curated by TDRTargets Show papers
    C14H18N2 Curated by TDRTargets Show papers
    C15H17N Curated by TDRTargets Show papers
    C15H20N2 Curated by TDRTargets Show papers
    C15H20N2 Curated by TDRTargets Show papers
    C16H19N Curated by TDRTargets Show papers
    C17H21N Curated by TDRTargets Show papers
    C17H21NO Curated by TDRTargets Show papers
    C17H21NO Curated by TDRTargets Show papers
    C17H24N2 Curated by TDRTargets Show papers
    C18H23N Curated by TDRTargets Show papers
    C18H23NO2 Curated by TDRTargets Show papers
    C18H23NO2 Curated by TDRTargets Show papers
    C19H27ClN5O4S Curated by TDRTargets Show papers
    C19H28ClN4O5S Curated by TDRTargets Show papers
    C19H31ClN3O4S Curated by TDRTargets Show papers
    C19H33ClN3O4S Curated by TDRTargets Show papers
    C20H25NO3 Curated by TDRTargets Show papers

  • Predicted associations

  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    27 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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