Detailed view for Rv2393

Basic information

TDR Targets ID: 8514
Mycobacterium tuberculosis, FERROCHELATASE CHE1

Source Database / ID: Tuberculist / Rv2393 

pI: 11.4257 | Length (AA): 282 | MW (Da): 29749 | Number of Paralogs: 2

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF01903   CbiX

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0016829   lyase activity  
GO:0046872   metal ion binding  

Process: (mouse over links to read term descriptions)

GO:0009236   cobalamin biosynthetic process  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

GO:0008150 biological_process
GO:0016829 lyase activity

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 11
Cumulative epitope score: 12.4
Normalized epitope score: 4.4
Percentile: 33.6 (this protein belongs to the top 66.4% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_16514
Number of Paralogs: 2

Ortholog group members from selected species:
Arabidopsis thaliana NP_564562   ATSIRB (ARABIDOPSIS THALIANA SIROHYDROCHLORIN FERROCHELATAS... |   OrthoMCL
Mycobacterium tuberculosis Rv2393 (this record).   FERROCHELATASE CHE1... |   OrthoMCL
Mycobacterium tuberculosis Rv0259c   CONSERVED HYPOTHETICAL PROTEIN... |   OrthoMCL
Oryza sativa NP_001046609   Os02g0296800 ... |   OrthoMCL

Essentiality Rv2393 has essentiality data
Gene/Ortholog: mtu262 (OG4_16514); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2434 (OG4_16514); Phenotype: non-essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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