Detailed view for Rv2395

Basic information

TDR Targets ID: 8515
Mycobacterium tuberculosis, PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN

Source Database / ID: Tuberculist / Rv2395 

pI: 9.94 | Length (AA): 667 | MW (Da): 68251 | Number of Paralogs: 0

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 18

Pfam domains

PF03169   OPT

Gene Ontology No GO information for this protein.
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 24
Cumulative epitope score: 27.8
Normalized epitope score: 4.2
Percentile: 25.3 (this protein belongs to the top 74.7% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_13001
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_567694   YSL1 (YELLOW STRIPE LIKE 1); oligopeptide transporter ... |   OrthoMCL
Arabidopsis thaliana NP_200167   YSL3 (YELLOW STRIPE LIKE 3); oligopeptide transporter ... |   OrthoMCL
Arabidopsis thaliana NP_566806   YSL6 (YELLOW STRIPE LIKE 6); oligopeptide transporter ... |   OrthoMCL
Arabidopsis thaliana NP_566584   YSL5 (YELLOW STRIPE LIKE 5); oligopeptide transporter ... |   OrthoMCL
Arabidopsis thaliana NP_197826   YSL2 (YELLOW STRIPE LIKE 2); oligopeptide transporter ... |   OrthoMCL
Arabidopsis thaliana NP_176750   YSL7 (YELLOW STRIPE LIKE 7); oligopeptide transporter ... |   OrthoMCL
Arabidopsis thaliana NP_564525   YSL8 (YELLOW STRIPE LIKE 8); oligopeptide transporter ... |   OrthoMCL
Arabidopsis thaliana NP_198916   YSL4 (YELLOW STRIPE LIKE 4); oligopeptide transporter ... |   OrthoMCL
Cryptosporidium neoformas XP_571335   hypothetical protein ... |   OrthoMCL
Mycobacterium tuberculosis Rv2395 (this record).   PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN... |   OrthoMCL
Oryza sativa NP_001053350   Os04g0524500 ... |   OrthoMCL
Oryza sativa NP_001044692   Os01g0829900 ... |   OrthoMCL
Oryza sativa NP_001052641   Os04g0390600 ... |   OrthoMCL
Oryza sativa NP_001053353   Os04g0524900 ... |   OrthoMCL
Oryza sativa NP_001052640   Os04g0390500 ... |   OrthoMCL
Oryza sativa NP_001053449   Os04g0542200 ... |   OrthoMCL
Oryza sativa NP_001053450   Os04g0542800 ... |   OrthoMCL
Oryza sativa NP_001061442   Os08g0280300 ... |   OrthoMCL
Oryza sativa NP_001045677   Os02g0116300 ... |   OrthoMCL
Oryza sativa NP_001053351   Os04g0524600 ... |   OrthoMCL
Oryza sativa NP_001054241   Os04g0674600 ... |   OrthoMCL
Oryza sativa NP_001045678   Os02g0116400 ... |   OrthoMCL
Oryza sativa NP_001047586   Os02g0649900 ... |   OrthoMCL
Oryza sativa NP_001042539   Os01g0238700 ... |   OrthoMCL
Saccharomyces cerevisiae YGL114W   YGL114W SGDID:S000003082, Chr VII from 293463-295640, Unchar... |   OrthoMCL

Essentiality Rv2395 has essentiality data
Gene/Ortholog: mtu2436 (OG4_13001); Phenotype: non-essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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