A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 6801 Mycobacterium tuberculosis, PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKNI (PROTEIN KINASE I) (STPK I) (PHOSPHORYLASE B KINASE KINASE) (HYDRO Source Database / ID: Tuberculist / Rv2914c
pI: 5.63 | Length (AA): 585 | MW (Da): 61805 | Number of Paralogs: 6
EC number(s): 2.7.1.- | Enzyme, KEGG, Brenda (mouse over to display more information) 2.7.11.1 | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1
[DGPI v2.04]
PF00069 Pkinase
Function: (mouse over links to read term descriptions)
Process: (mouse over links to read term descriptions)
This gene is not mapped to any metabolic pathway in KEGG.
No functional classes assigned to this gene.
Modbase 3D models: 0 no model available for this protein in Modbase.
[+/–] Help me make sense of these data. Target Beg: first modeled residue Target End: last modeled residue Template: template structure used for modelling (PDB accession and chain) Template Beg: first template residue in target-template alignment Template End: last template residue in target-template alignment Identity: sequence identity Evalue: E value for target-template hit Model Score: GA341 score (>0.7 for reliable model) MPQS: ModPipe Quality Score (>1.1 for reliable model) zDope: zDope Score (negative for reliable model) A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the upper 80-100% group of genes. Shows this level of upregulation in: Dormant phase.
Upregulation ranking: this gene ranks in the mid 40-60% group of genes. Shows this level of upregulation in: Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 29 Cumulative epitope score: 32.5 Normalized epitope score: 5.6 Percentile: 85.4 (this protein belongs to the top 14.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_23912 Number of Paralogs: 6
Ortholog group members from selected species: Giardia intestinalis GL50581_1642 Kinase, NEK ... | OrthoMCL Giardia intestinalis GL50581_868 Kinase, NEK ... | OrthoMCL Giardia lamblia GLP15_3141 Kinase, NEK ... | OrthoMCL Giardia lamblia GLP15_1780 Kinase, NEK ... | OrthoMCL Mycobacterium tuberculosis Rv1743 PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE E PKN... | OrthoMCL Mycobacterium tuberculosis Rv1266c PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKN... | OrthoMCL Mycobacterium tuberculosis Rv2914c (this record). PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKN... | OrthoMCL Mycobacterium tuberculosis Rv2088 PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE J PKN... | OrthoMCL
[+/–] Show essentiality data references.
We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
Curated from literature
No chemical compounds associated to this gene
Predicted associations
By orthology to known druggable targets
From ChEMBL
From TDR Targets
By sequence similarity to non orthologous druggable targets
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
User: ()
Gene identifier: Rv2914c Mycobacterium tuberculosis, PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKNI (PROTEIN KINASE I) (STPK I) (PHOSPHORYLASE B KINASE KINASE) (HYDRO
79 literature references were collected for this gene.
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