Detailed view for Rv2914c

Basic information

TDR Targets ID: 6801
Mycobacterium tuberculosis, PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKNI (PROTEIN KINASE I) (STPK I) (PHOSPHORYLASE B KINASE KINASE) (HYDRO

Source Database / ID: Tuberculist / Rv2914c 

pI: 5.63 | Length (AA): 585 | MW (Da): 61805 | Number of Paralogs: 6

EC number(s): 2.7.1.- | Enzyme, KEGG, Brenda (mouse over to display more information)
2.7.11.1 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1

Pfam domains

PF00069   Pkinase

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  

Process: (mouse over links to read term descriptions)

GO:0006468   protein amino acid phosphorylation  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 80-100% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 29
Cumulative epitope score: 32.5
Normalized epitope score: 5.6
Percentile: 85.4 (this protein belongs to the top 14.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_23912
Number of Paralogs: 6

Ortholog group members from selected species:
Giardia intestinalis GL50581_1642   Kinase, NEK ... |   OrthoMCL
Giardia intestinalis GL50581_868   Kinase, NEK ... |   OrthoMCL
Giardia lamblia GLP15_3141   Kinase, NEK ... |   OrthoMCL
Giardia lamblia GLP15_1780   Kinase, NEK ... |   OrthoMCL
Mycobacterium tuberculosis Rv1743   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE E PKN... |   OrthoMCL
Mycobacterium tuberculosis Rv1266c   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE H PKN... |   OrthoMCL
Mycobacterium tuberculosis Rv2914c (this record).   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKN... |   OrthoMCL
Mycobacterium tuberculosis Rv2088   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE J PKN... |   OrthoMCL

Essentiality Rv2914c has essentiality data
Gene/Ortholog: mtu1773 (OG4_23912); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1287 (OG4_23912); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2961 (OG4_23912); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2121 (OG4_23912); Phenotype: non-essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    79 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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