pI: 5.1781 |
Length (AA): 1127 |
MW (Da): 120392 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 1127 | 3hbl (A) | 37 | 1178 | 45.00 | 0 | 1 | 1.53061 | -0.23 |
2 | 1127 | 5vz0 (A) | 1 | 1137 | 44.00 | 0 | 1 | 1.56161 | -0.44 |
2 | 453 | 2dzd (A) | 6 | 461 | 51.00 | 0 | 1 | 1.05156 | -0.62 |
3 | 450 | 2vpq (A) | 2 | 447 | 41.00 | 0 | 1 | 0.966016 | -0.8 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126626)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G03090 | methylcrotonoyl-CoA carboxylase subunit alpha |
Arabidopsis thaliana | AT5G35360 | biotin carboxylase subunit CAC2 |
Candida albicans | CaO19.789 | likely pyruate carboxylase similar to S. cerevisiae PYC2 (YBR218C) and to Pichia angusta PYC (AAL69566) involved in assembly of |
Candida albicans | CaO19.780 | likely multifunctional enzyme similar to S. cerevisiae DUR1,2 (YBR208C) urea carboxylase and allophanate hydrolase |
Candida albicans | CaO19.8408 | likely pyruate carboxylase similar to S. cerevisiae PYC2 (YBR218C) and to Pichia angusta PYC (AAL69566) involved in assembly of |
Candida albicans | CaO19.8402 | likely multifunctional enzyme similar to S. cerevisiae DUR1,2 (YBR208C) urea carboxylase and allophanate hydrolase |
Caenorhabditis elegans | CELE_D2023.2 | Protein PYC-1, isoform B |
Caenorhabditis elegans | CELE_F32B6.12 | Protein MCCC-1 |
Caenorhabditis elegans | CELE_F27D9.5 | Protein PCCA-1 |
Chlamydia trachomatis | CT_124 | biotin carboxylase |
Dictyostelium discoideum | DDB_G0287377 | 3-methylcrotonyl-CoA:carbon dioxide ligase alpha subunit |
Dictyostelium discoideum | DDB_G0275355 | propanoyl-CoA:carbon dioxide ligase alpha subunit |
Drosophila melanogaster | Dmel_CG2118 | CG2118 gene product from transcript CG2118-RC |
Drosophila melanogaster | Dmel_CG1516 | CG1516 gene product from transcript CG1516-RE |
Escherichia coli | b3256 | acetyl-CoA carboxylase, biotin carboxylase subunit |
Echinococcus granulosus | EgrG_000534100 | propionyl coenzyme A carboxylase alpha chain |
Entamoeba histolytica | EHI_082530 | acetyl-coA carboxylase, putative |
Echinococcus multilocularis | EmuJ_000534100 | propionyl coenzyme A carboxylase alpha chain |
Giardia lamblia | GL50803_113021 | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative |
Homo sapiens | ENSG00000175198 | propionyl CoA carboxylase, alpha polypeptide |
Homo sapiens | ENSG00000173599 | pyruvate carboxylase |
Homo sapiens | ENSG00000078070 | methylcrotonoyl-CoA carboxylase 1 (alpha) |
Leishmania braziliensis | LbrM.31.3570 | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein |
Leishmania braziliensis | LbrM.01.0080 | carboxylase, putative |
Leishmania donovani | LdBPK_010050.1 | carboxylase, putative |
Leishmania donovani | LdBPK_313260.1 | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein |
Leishmania infantum | LinJ.01.0050 | carboxylase, putative |
Leishmania infantum | LinJ.31.3260 | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein |
Leishmania major | LmjF.01.0050 | carboxylase, putative |
Leishmania major | LmjF.31.3130 | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein |
Leishmania mexicana | LmxM.01.0050 | carboxylase, putative |
Leishmania mexicana | LmxM.30.3130 | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein |
Mycobacterium leprae | ML0726c | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) |
Mus musculus | ENSMUSG00000027709 | methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) |
Mus musculus | ENSMUSG00000024892 | pyruvate carboxylase |
Mus musculus | ENSMUSG00000041650 | propionyl-Coenzyme A carboxylase, alpha polypeptide |
Mycobacterium tuberculosis | Rv2501c | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrie |
Mycobacterium tuberculosis | Rv2967c | Probable pyruvate carboxylase Pca (pyruvic carboxylase) |
Mycobacterium ulcerans | MUL_1992 | pyruvate carboxylase |
Mycobacterium ulcerans | MUL_3779 | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 |
Neospora caninum | NCLIV_028990 | hypothetical protein |
Oryza sativa | 4352741 | Os12g0605800 |
Saccharomyces cerevisiae | YGL062W | pyruvate carboxylase 1 |
Saccharomyces cerevisiae | YBR208C | bifunctional urea carboxylase/allophanate hydrolase |
Saccharomyces cerevisiae | YBR218C | pyruvate carboxylase 2 |
Schistosoma japonicum | Sjp_0089840 | ko:K01965 propionyl-CoA carboxylase alpha chain [EC6.4.1.3A], putative |
Schistosoma japonicum | Sjp_0089850 | IPR000571,Zinc finger, CCCH-type,domain-containing |
Schistosoma japonicum | Sjp_0056500 | ko:K01959 pyruvate carboxylase subunit A [EC6.4.1.1A], putative |
Schistosoma mansoni | Smp_165400.3 | methylcrotonyl-CoA carboxylase |
Schistosoma mansoni | Smp_141360 | pyruvate carboxylase |
Schistosoma mansoni | Smp_165400.1 | methylcrotonyl-CoA carboxylase |
Schmidtea mediterranea | mk4.005708.02 | Pyruvate carboxylase 1 |
Schmidtea mediterranea | mk4.002747.03 | |
Schmidtea mediterranea | mk4.001068.01 | |
Schmidtea mediterranea | mk4.003313.02 | Pyruvate carboxylase 1 |
Schmidtea mediterranea | mk4.003948.02 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial |
Schmidtea mediterranea | mk4.000717.00 | Propionyl-CoA carboxylase alpha chain, mitochondrial |
Schmidtea mediterranea | mk4.004740.01 | |
Schmidtea mediterranea | mk4.003948.01 | |
Schmidtea mediterranea | mk4.003313.03 | Pyruvate carboxylase 1 |
Trypanosoma brucei gambiense | Tbg972.8.7180 | 3-methylcrotonyl-CoA carboxylase, putative |
Trypanosoma brucei | Tb927.8.6970 | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative |
Trypanosoma congolense | TcIL3000_0_12080 | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative |
Trypanosoma congolense | TcIL3000_0_34810 | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative |
Trypanosoma congolense | TcIL3000_8_6930 | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative |
Trypanosoma cruzi | TcCLB.504835.20 | 3-methylcrotonyl-CoA carboxylase, putative |
Trypanosoma cruzi | TcCLB.509913.10 | 3-methylcrotonyl-CoA carboxylase, putative |
Toxoplasma gondii | TGME49_284190 | pyruvate carboxylase |
Treponema pallidum | TP0056 | pyruvate carboxylase subunit B |
Wolbachia endosymbiont of Brugia malayi | Wbm0455 | Acetyl/propionyl-CoA carboxylase, alpha subunit |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6970 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6970 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6970 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6970 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3256 | Escherichia coli | essential | goodall |
TGME49_284190 | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.