A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 9008 Mycobacterium tuberculosis, PROBABLE TWO COMPONENT SENSOR KINASE Source Database / ID: Tuberculist / Rv3220c
pI: 5.58 | Length (AA): 501 | MW (Da): 54012 | Number of Paralogs: 0
EC number(s): 2.7.3.- | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
PF07568 HisKA_2 PF08448 PAS_4
Function: (mouse over links to read term descriptions)
Process: (mouse over links to read term descriptions)
This gene is not mapped to any metabolic pathway in KEGG.
GO:0005488 binding GO:0009987 cellular process GO:0016301 kinase activity GO:0016772 transferase activity, transferring phosphorus-containing groups
Modbase 3D models: 0 no model available for this protein in Modbase.
[+/–] Help me make sense of these data. Target Beg: first modeled residue Target End: last modeled residue Template: template structure used for modelling (PDB accession and chain) Template Beg: first template residue in target-template alignment Template End: last template residue in target-template alignment Identity: sequence identity Evalue: E value for target-template hit Model Score: GA341 score (>0.7 for reliable model) MPQS: ModPipe Quality Score (>1.1 for reliable model) zDope: zDope Score (negative for reliable model) A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the upper 60-80% group of genes. Shows this level of upregulation in: Dormant phase.
Upregulation ranking: this gene ranks in the lower 20-40% group of genes. Shows this level of upregulation in: Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 21 Cumulative epitope score: 24.0 Normalized epitope score: 4.8 Percentile: 52.4 (this protein belongs to the top 47.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_45690 Number of Paralogs: 0
Ortholog group members from selected species: Mycobacterium leprae strain TN ML0803 Probable two-component sensor kinase... | OrthoMCL Mycobacterium tuberculosis Rv3220c (this record). PROBABLE TWO COMPONENT SENSOR KINASE... | OrthoMCL
No essentiality data collected for this gene and/or its orthologs.
We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
Curated from literature
No chemical compounds associated to this gene
Predicted associations
By orthology to known druggable targets
From ChEMBL
By sequence similarity to non orthologous druggable targets
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
User: ()
Gene identifier: Rv3220c Mycobacterium tuberculosis, PROBABLE TWO COMPONENT SENSOR KINASE
21 literature references were collected for this gene.
If you have references for this gene, please enter them in a user comment (below) or contact us.
No user comments are available for this gene.
Log in to add comments, or register.
