TDR Targets

Detailed view for Rv3220c

Basic information

TDR Targets ID: 9008
Mycobacterium tuberculosis, PROBABLE TWO COMPONENT SENSOR KINASE
Source Database / ID: Tuberculist / Rv3220c

pI: 5.5774 | Length (AA): 501 | MW (Da): 54012 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF07568 Histidine kinase
PF12282 Signal transduction histidine kinase

Gene Ontology

Mouse over links to read term descriptions.

GO:0005524 ATP binding
GO:0004673 protein histidine kinase activity
GO:0000155 two-component sensor activity
GO:0018106 peptidyl-histidine phosphorylation
GO:0007165 signal transduction

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

2YKF: Sensor region of a sensor histidine kinase
Preu, J., Panjikar, S., Morth, P., Jaiswal, R., Karunakar, P., Tucker, P.A.

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date
2.00	X-RAY DIFFRACTION	2028	305	2011-05-26	2012-06-06	2015-09-23

Ligand information

BROMIDE ION

[Br-]

non-polymer

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SULFATE ION

[O-]S(=O)(=O)[O-]

non-polymer

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2YKH: Sensor region of a sensor histidine kinase
Preu, J., Panjikar, S., Morth, P., Jaiswal, R., Karunakar, P., Tucker, P.A.

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date
2.78	X-RAY DIFFRACTION	3976	610	2011-05-27	2012-06-06	2012-06-27

Expression

Upregulation Percent	Ranking	Shows this level of upregulation in
This gene ranks in the upper 60-80% group of genes.		Dormant phase.

Upregulation Percent	Ranking	Shows this level of upregulation in
This gene ranks in the lower 20-40% group of genes.		Dormant phase.

Show/Hide expression data references

murphy

Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

hasan

Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_160461)
Species	Accession	Gene Product
Mycobacterium leprae	ML0803	Putative two-component system sensor kinase
Mycobacterium tuberculosis	Rv3220c this record	PROBABLE TWO COMPONENT SENSOR KINASE
Mycobacterium ulcerans	MUL_2542	sensor kinase from two component regulatory system

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets

Non orthologous druggable targets

By sequence similarity to non orthologous druggable targets

No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

21 literature references were collected for this gene.

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User comments

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Gene identifier	Rv3220c (Mycobacterium tuberculosis), PROBABLE TWO COMPONENT SENSOR KINASE

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