Detailed view for Rv3220c

Basic information

TDR Targets ID: 9008
Mycobacterium tuberculosis, PROBABLE TWO COMPONENT SENSOR KINASE

Source Database / ID: Tuberculist / Rv3220c 

pI: 5.5774 | Length (AA): 501 | MW (Da): 54012 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF02518   Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF07568   Histidine kinase
PF12282   Signal transduction histidine kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004673   protein histidine kinase activity  
GO:0000155   two-component sensor activity  
GO:0018106   peptidyl-histidine phosphorylation  
GO:0007165   signal transduction  

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

Expression

Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the upper 60-80% group of genes. Dormant phase.
Upregulation Percent Ranking Shows this level of upregulation in
This gene ranks in the lower 20-40% group of genes. Dormant phase.
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_160461)
Species Accession Gene Product
Mycobacterium leprae ML0803   Putative two-component system sensor kinase
Mycobacterium tuberculosis Rv3220c this record   PROBABLE TWO COMPONENT SENSOR KINASE
Mycobacterium ulcerans MUL_2542   sensor kinase from two component regulatory system

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

21 literature references were collected for this gene.

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User comments

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Gene identifier Rv3220c (Mycobacterium tuberculosis), PROBABLE TWO COMPONENT SENSOR KINASE
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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