Detailed view for Rv3220c

Basic information

TDR Targets ID: 9008
Mycobacterium tuberculosis, PROBABLE TWO COMPONENT SENSOR KINASE

Source Database / ID: Tuberculist / Rv3220c 

pI: 5.58 | Length (AA): 501 | MW (Da): 54012 | Number of Paralogs: 0

EC number(s): 2.7.3.- | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF07568   HisKA_2
PF08448   PAS_4

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0005524   ATP binding  
GO:0004673   protein histidine kinase activity  
GO:0000155   two-component sensor activity  

Process: (mouse over links to read term descriptions)

GO:0018106   peptidyl-histidine phosphorylation  
GO:0007165   signal transduction  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

GO:0005488 binding
GO:0009987 cellular process
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 21
Cumulative epitope score: 24.0
Normalized epitope score: 4.8
Percentile: 52.4 (this protein belongs to the top 47.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_45690
Number of Paralogs: 0

Ortholog group members from selected species:
Mycobacterium leprae strain TN ML0803   Probable two-component sensor kinase... |   OrthoMCL
Mycobacterium tuberculosis Rv3220c (this record).   PROBABLE TWO COMPONENT SENSOR KINASE... |   OrthoMCL

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    21 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

    Log in to add comments, or register.