Detailed view for Rv3420c

Basic information

TDR Targets ID: 980566
Mycobacterium tuberculosis, Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
Source Database / ID:  Tuberculist 

pI: 8.0183 | Length (AA): 158 | MW (Da): 17357 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 156 1yre (A) 13 181 23.00 0 1 1.21994 -0.25
6 153 2ree (A) 226 420 16.00 0 1 0.920309 -0.69
8 153 2cnt (A) 2 145 31.00 0 1 1.26965 -0.47
64 131 1yvk (A) 51 121 32.00 0.014 1 0.82778 -0.3
77 109 5ib0 (A) 69 101 48.00 0.81 0.92 0.616261 0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126956)

Species Accession Gene Product
Arabidopsis thaliana AT5G13780   peptide alpha-N-acetyltransferase
Babesia bovis BBOV_II004010   N-acetyltransferase, putative
Brugia malayi Bm1_15190   N-terminal acetyltransferase complex ARD1 subunit homolog
Brugia malayi Bm1_03265   N-terminal acetyltransferase complex ARD1 subunit homolog
Candida albicans CaO19.7617   potential peptide N-acetyl tranferase (GNAT family) similar to S. cerevisiae ARD1 (YHR013C) subunit of the Ard1p/Nat1p major pep
Caenorhabditis elegans CELE_K07H8.3   Protein K07H8.3
Cryptosporidium hominis Chro.50064   N-acetyltransferase
Cryptosporidium parvum cgd5_3090   N-acetyltransferase subunit ARD1
Dictyostelium discoideum DDB_G0275449   N-acetyltransferase complex subunit
Drosophila melanogaster Dmel_CG11989   variable nurse cells
Escherichia coli b4373   ribosomal-protein-S18-alanine N-acetyltransferase
Echinococcus granulosus EgrG_000792500   N alpha acetyltransferase 11
Entamoeba histolytica EHI_005070   acetyltransferase, GNAT family
Entamoeba histolytica EHI_186730   acetyltransferase, GNAT family
Echinococcus multilocularis EmuJ_000792500   N alpha acetyltransferase 11
Giardia lamblia GL50803_8707   N-terminal acetyltransferase complex ARD1 subunit, putative
Homo sapiens 8260   N(alpha)-acetyltransferase 10, NatA catalytic subunit
Homo sapiens 84779   N(alpha)-acetyltransferase 11, NatA catalytic subunit
Leishmania braziliensis LbrM.29.2720   hypothetical protein, conserved
Leishmania donovani LdBPK_130260.1   N-acetyltransferase subunit ARD1, putative
Leishmania infantum LinJ.13.0260   N-acetyltransferase subunit ARD1, putative
Leishmania major LmjF.13.0260   N-acetyltransferase subunit ARD1, putative
Leishmania mexicana LmxM.13.0260   N-acetyltransferase subunit ARD1, putative
Loa Loa (eye worm) LOAG_10487   n-terminal acetyltransferase complex ard1 subunit
Mus musculus ENSMUSG00000031388   N(alpha)-acetyltransferase 10, NatA catalytic subunit
Mus musculus ENSMUSG00000046000   N(alpha)-acetyltransferase 11, NatA catalytic subunit
Mycobacterium tuberculosis Rv3420c   Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
Mycobacterium ulcerans MUL_0883   ribosomal-protein-alanine acetyltransferase, RimI
Neospora caninum NCLIV_060850   N-terminal acetyltransferase complex subunit ARD1, putative
Oryza sativa 4337136   Os04g0635800
Onchocerca volvulus OVOC6155  
Plasmodium berghei PBANKA_1201700   N-terminal acetyltransferase A complex catalytic subunit ARD1, putative
Plasmodium falciparum PF3D7_1003300   N-terminal acetyltransferase A complex catalytic subunit ARD1, putative
Plasmodium knowlesi PKNH_0802100   N-terminal acetyltransferase A complex catalytic subunit ARD1, putative
Plasmodium vivax PVX_094365   N-acetyltransferase, putative
Plasmodium yoelii PY00941   hypothetical protein
Saccharomyces cerevisiae YHR013C   Ard1p
Schistosoma japonicum Sjp_0031810   ko:K00680 N-acetyltransferase ARD1 homolog [EC:2.3.1.-], putative
Schistosoma mansoni Smp_050590   n-terminal acetyltransferase complex ard1 subunit
Schmidtea mediterranea mk4.000152.10   Putative n-terminal acetyltransferase complex ard1 subunit
Trypanosoma brucei gambiense Tbg972.11.5170   N-acetyltransferase subunit ARD1, putative
Trypanosoma brucei Tb927.11.4530   N-acetyltransferase subunit ARD1
Trypanosoma congolense TcIL3000.11.4620   N-acetyltransferase subunit ARD1, putative
Trypanosoma cruzi TcCLB.506227.230   N-acetyltransferase complex ARD1 subunit, putative
Toxoplasma gondii TGME49_219760   N-acetyltransferase family protein
Theileria parva TP04_0161   N-acetyltransferase, putative
Trichomonas vaginalis TVAG_099870   N-acetyltransferase, putative
Trichomonas vaginalis TVAG_497420   ribosomal-protein-alanine acetyltransferase, putative
Trichomonas vaginalis TVAG_363980   N-acetyltransferase, putative
Trichomonas vaginalis TVAG_159840   ribosomal-protein-alanine acetyltransferase, putative

Essentiality

Rv3420c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2110 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.2110 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.2110 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.2110 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b4373 Escherichia coli non-essential goodall
CELE_K07H8.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_K07H8.3 Caenorhabditis elegans larval arrest wormbase
TGME49_219760 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3420c (Mycobacterium tuberculosis), Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18)
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