Detailed view for Rv3606c

Basic information

TDR Targets ID: 980271
Mycobacterium tuberculosis, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (
Source Database / ID:  Tuberculist 

pI: 6.1031 | Length (AA): 188 | MW (Da): 20732 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Folate biosynthesis (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 164 5etr (B) 1 156 32.00 0 1 1.24054 -0.81
1 170 2qx0 (A) 1 159 36.00 0 1 1.27846 -0.77
1 145 5etr (B) 1 144 38.00 0 1 1.16208 -0.56
1 169 1cbk (A) 1 158 28.00 0 1 1.21654 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133110)

Species Accession Gene Product
Escherichia coli b0142   2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase
Mycobacterium leprae ML0226   Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin
Mycobacterium tuberculosis Rv3606c   2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (
Mycobacterium ulcerans MUL_4188   2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Staphylococcus aureus 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase Compounds References
Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1495 0.7693 1
3.8479 0.7702 1
3.5146 0.6975 0.5
3.5279 0.6955 0.5
0.682 0.6909 0.5
0.0791 0.2663 0.9245
0.0458 0.7017 0.5
2.4012 0.7696 1
0.0882 0.5907 0.5
0.0791 0.2659 0.9238
0.2277 0.7697 0.5
2.2327 0.6984 0.5
0.0882 0.3046 1
0.0882 0.7673 1
1.8693 0.7686 1
0.0791 0.2663 0.9245
0.0662 0.7683 1
0.0882 0.6081 1
0.3869 0.6822 0.5
0.1416 0.5871 0.6359
1.1237 0.7699 1
0.1498 0.5784 0.5
0.235 0.7017 0.5
3.8535 0.7694 1
4.0144 0.7669 1
0.072 0.7614 0.5
0.3188 0.77 1
1.0169 0.6695 0.5
1.1646 0.7464 1
0.32 0.7632 1
1.1207 0.6552 0.5
0.3335 0.3121 1
0.0791 0.2659 0.9527
0.1498 0.6502 1
0.4076 0.6837 0.5
3.8479 0.7702 1
2.5227 0.6959 0.5
4.1405 0.6983 0.5
0.0679 0.767 1
4.8336 0.7701 1
3.7382 0.6956 0.5
0.4201 0.7673 1
0.4564 0.7698 1
0.072 0.7614 0.5
0.0786 0.2672 0.9527
1.1963 0.6515 0.5
0.0856 0.7655 0.5
1.2698 0.77 1
3.2349 0.6952 0.5
3.621 0.7701 1
0.146 0.765 1
3.8032 0.768 1
0.083 0.2659 0.9527
0.1664 0.7689 1
0.0786 0.2672 0.9527
0.0882 0.7469 1
0.087 0.2668 1
4.8336 0.7701 1
3.1526 0.695 0.5
0.0882 0.5646 0.5
0.1498 0.5784 0.5
0.146 0.765 1
0.9 0.7701 1
3.2195 0.7675 1
0.0882 0.4212 1
0.9354 0.7698 1
0.083 0.2659 0.9527
1.1237 0.7699 1
0.0791 0.2659 0.9238
0.9126 0.7698 0.5
0.3188 0.77 1
0.0436 0.7017 0.5
3.8032 0.768 1
3.7889 0.7701 1
0.0786 0.2684 0.9533
0.0882 0.5646 0.5
3.8479 0.7702 1
3.6913 0.7699 1
3.2582 0.7695 1
3.5874 0.6957 0.5
0.1764 0.7645 0.5
4.3364 0.6966 0.5
0.0786 0.2684 0.9533
1.1172 0.7693 1
3.8032 0.768 1
0.1764 0.769 1
3.3257 0.6952 0.5
0.0454 0.5052 0.5
0.4708 0.7605 0.5
2.4012 0.7696 1
1.208 0.77 1
3.8535 0.7694 1
0.3755 0.7315 1
0.32 0.7632 1
0.3232 0.7134 1
0.0882 0.5646 0.5
0.083 0.2659 0.9527
0.0882 0.5646 0.5
1.208 0.77 1
0.974 0.7464 1
0.9354 0.7698 1
0.47 0.6847 0.5
0.083 0.2659 0.9527
2.4012 0.7696 1
0.8418 0.7666 0.5
0.0756 0.7293 1
3.4078 0.6953 0.5
4.0665 0.6962 0.5
1.1352 0.767 1
0.0882 0.7626 0.5
2.5796 0.6957 0.5
0.5151 0.726 0.5
0.083 0.2659 0.9527
3.5728 0.7648 0.5
0.0662 0.7683 1
3.8004 0.6959 0.5
0.1662 0.7633 0.5
0.1534 0.7684 1
0.3892 0.7693 1
0.1498 0.5784 0.5
0.0882 0.414 1
3.8578 0.6959 0.5
1.2698 0.77 1
0.0882 0.7625 1
3.2143 0.7699 1
3.8032 0.768 1
1.0101 0.6602 0.5
0.1764 0.6459 0.5
0.0882 0.7663 1
1.1936 0.6515 0.5
0.3335 0.3121 1
3.2582 0.7695 1
0.0756 0.7293 1
0.5024 0.4883 1
0.0514 0.7571 0.5
0.1498 0.5784 0.5
1.1963 0.7701 1
2.6959 0.7695 1
0.0882 0.5536 1
2.9485 0.7702 1
0.054 0.7479 0.8043
0.7448 0.7473 0.5
2.7291 0.7693 1
3.8032 0.768 1
0.1664 0.7689 1
0.169 0.6459 0.5
0.087 0.2668 1
3.8479 0.7702 1
1.0134 0.77 1
3.2195 0.7675 1
0.3816 0.7649 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3606c (Mycobacterium tuberculosis), 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (
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