Detailed view for Rv3721c

Basic information

TDR Targets ID: 981066
Mycobacterium tuberculosis, DNA polymerase III (subunit gamma/tau) DnaZ/X
Source Database / ID:  Tuberculist 

pI: 5.6835 | Length (AA): 578 | MW (Da): 61891 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 365 3glg (G) 5 361 37.00 0 1 1.11486 -0.33
303 461 5cwk (A) 2 159 14.00 0.85 0.05 0.465187 -0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127045)

Species Accession Gene Product
Arabidopsis thaliana AT2G02480   protein STICHEL
Arabidopsis thaliana AT1G77470   replication factor C subunit 3
Arabidopsis thaliana AT1G14460   AAA-type ATPase family protein
Babesia bovis BBOV_II002510   replication factor C3 protein, putative
Brugia malayi Bm1_41025   Putative activator 1 36 kDa subunit
Candida albicans CaO19.10723   Replication factor C subunit 3
Candida albicans CaO19.3211   Replication factor C subunit 3
Caenorhabditis elegans CELE_F44B9.8   Protein F44B9.8
Cryptosporidium hominis Chro.30359   replication factor C3
Cryptosporidium parvum cgd3_3170   replication factor RFC3 AAA+ ATpase
Chlamydia trachomatis CT_334   DNA polymerase III subunit gamma and tau
Dictyostelium discoideum DDB_G0282235   replication factor C subunit
Drosophila melanogaster Dmel_CG5313   Replication factor C subunit 3
Escherichia coli b0470   DNA polymerase III/DNA elongation factor III, tau and gamma subunits
Echinococcus granulosus EgrG_000570600   replication factor C subunit 5
Entamoeba histolytica EHI_099850   replication factor C familiy protein
Echinococcus multilocularis EmuJ_000570600   replication factor C subunit 5
Giardia lamblia GL50803_24636   Replication factor C, subunit 3
Homo sapiens ENSG00000111445   replication factor C (activator 1) 5, 36.5kDa
Leishmania braziliensis LbrM.34.3160   replication factor C, subunit 3, putative
Leishmania donovani LdBPK_353300.1   replication factor C, subunit 3, putative
Leishmania infantum LinJ.35.3300   replication factor C, subunit 3, putative
Leishmania major LmjF.35.3250   replication factor C, subunit 3, putative
Leishmania mexicana LmxM.34.3250   replication factor C, subunit 3, putative
Loa Loa (eye worm) LOAG_02279   replication factor C subunit 3
Mycobacterium leprae ML2335c   DNA POLYMERASE III (SUBUNIT GAMMA/TAU) DNAZ/X
Mus musculus 72151   replication factor C (activator 1) 5
Mycobacterium tuberculosis Rv3721c   DNA polymerase III (subunit gamma/tau) DnaZ/X
Mycobacterium ulcerans MUL_4315   DNA polymerase III subunits gamma and tau
Neospora caninum NCLIV_013120   activator 1 36 kDa, putative
Oryza sativa 9270748   Os11g0244300
Oryza sativa 4330895   Os02g0775200
Oryza sativa 4351770   Os12g0209300
Onchocerca volvulus OVOC9422   Putative replication factor C subunit 5
Plasmodium berghei PBANKA_1326800   replication factor C subunit 3, putative
Plasmodium falciparum PF3D7_1463200   replication factor C subunit 3, putative
Plasmodium knowlesi PKNH_1218300   replication factor C subunit 3, putative
Plasmodium vivax PVX_117300   replication factor C3, putative
Plasmodium yoelii PY04255   replication factor C3
Saccharomyces cerevisiae YNL290W   replication factor C subunit 3
Schistosoma japonicum Sjp_0046720   ko:K10756 replication factor C subunit 3/5, putative
Schistosoma mansoni Smp_178880   replication factor C / DNA polymerase III gamma-tau subunit
Schistosoma mansoni Smp_066260   replication factor C / DNA polymerase III gamma-tau subunit
Schmidtea mediterranea mk4.056823.00   Replication factor C subunit 4
Schmidtea mediterranea mk4.001716.00   Probable replication factor C subunit 5
Trypanosoma brucei gambiense Tbg972.9.7480   replication factor C, subunit 3, putative
Trypanosoma brucei Tb927.9.12300   replication factor C, subunit 3, putative
Trypanosoma cruzi TcCLB.510737.110   replication factor C, subunit 3, putative
Trypanosoma cruzi TcCLB.510661.270   replication factor C, subunit 3, putative
Toxoplasma gondii TGME49_213000   replication factor C, subunit 5, putative
Treponema pallidum TP1005   DNA polymerase III subunits gamma and tau
Theileria parva TP04_0380   replication factor C subunit 3, putative
Trichomonas vaginalis TVAG_447650   werner helicase interacting protein, putative
Wolbachia endosymbiont of Brugia malayi Wbm0434   DNA polymerase III, gamma/tau subunit

Essentiality

Rv3721c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.3310 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.3310 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.3310 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.3310 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b0470 Escherichia coli essential goodall
CELE_F44B9.8 Caenorhabditis elegans embryonic lethal wormbase
YNL290W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1326800 Plasmodium berghei Essential plasmo
TGME49_213000 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv3721c (Mycobacterium tuberculosis), DNA polymerase III (subunit gamma/tau) DnaZ/X
Title for this comment
Comment