Detailed view for Rv3764c

Basic information

TDR Targets ID: 9953
Mycobacterium tuberculosis, POSSIBLE TWO COMPONENT SENSOR KINASE TCRY

Source Database / ID: Tuberculist / Rv3764c 

pI: 7.5042 | Length (AA): 476 | MW (Da): 50312 | Number of Paralogs: 3

EC number(s): 2.7.13.3 | Enzyme, KEGG, Brenda (mouse over to display more information)
2.7.3.- | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1

Pfam domains

PF00512   HisKA
PF00672   HAMP

Gene Ontology

Component: (mouse over links to read term descriptions)

GO:0016021   integral to membrane  
GO:0016020   membrane  

Function: (mouse over links to read term descriptions)

GO:0005524   ATP binding  
GO:0004871   signal transducer activity  
GO:0004673   protein histidine kinase activity  
GO:0000155   two-component sensor activity  

Process: (mouse over links to read term descriptions)

GO:0018106   peptidyl-histidine phosphorylation  
GO:0016310   phosphorylation  
GO:0007165   signal transduction  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 22
Cumulative epitope score: 24.9
Normalized epitope score: 5.2
Percentile: 73.1 (this protein belongs to the top 26.9% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_11673
Number of Paralogs: 3

Ortholog group members from selected species:
Escherichia coli K12 NP_415102.1   sensory histidine kinase in two-component regulatory system ... |   OrthoMCL
Escherichia coli K12 NP_414934.1   sensory histidine kinase in two-component regulatory system ... |   OrthoMCL
Escherichia coli K12 NP_416582.1   sensory histidine kinase in two-component regulatory system ... |   OrthoMCL
Mycobacterium leprae strain TN ML2440c   PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3... |   OrthoMCL
Mycobacterium tuberculosis Rv0758   POSSIBLE TWO COMPONENT SYSTEM RESPONSE SENSOR KINASE MEMBRAN... |   OrthoMCL
Mycobacterium tuberculosis Rv0490   PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3... |   OrthoMCL
Mycobacterium tuberculosis Rv3764c (this record).   POSSIBLE TWO COMPONENT SENSOR KINASE TCRY... |   OrthoMCL

Essentiality Rv3764c has essentiality data
Gene/Ortholog: mtu773 (OG4_11673); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu495 (OG4_11673); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu3829 (OG4_11673); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco390 (OG4_11673); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco390 (OG4_11673); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco390 (OG4_11673); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco390 (OG4_11673); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco558 (OG4_11673); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco558 (OG4_11673); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco558 (OG4_11673); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco558 (OG4_11673); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco2017 (OG4_11673); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco2017 (OG4_11673); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco2017 (OG4_11673); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco2017 (OG4_11673); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    21 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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