Detailed view for Tb09.160.5580

Basic information

TDR Targets ID: 10139
Trypanosoma brucei, 60S ribosomal protein L11, putative

Source Database / ID: GeneDB / Tb09.160.5580

pI: 11 | Length (AA): 194 | MW (Da): 22369 | Number of Paralogs: 2 | -.-.-.-

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00281   Ribosomal protein L5
PF00673   ribosomal L5P family C-terminus

Gene Ontology

Biological Process:
GO:0006412   translation   [+/–] show term definition

The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

Cellular component:
GO:0000315   organellar large ribosomal subunit   [+/–] show term definition

The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).

GO:0005842   cytosolic large ribosomal subunit (sensu Eukaryota)   [+/–] show term definition
GO:0005622   intracellular   [+/–] show term definition
GO:0005840   ribosome   [+/–] show term definition

Molecular Function:
GO:0003735   structural constituent of ribosome   [+/–] show term definition

The action of a molecule that contributes to the structural integrity of the ribosome.

Metabolic Pathways

Ribosome (KEGG)

Functional classes

GO:0005198 structural molecule activity
GO:0009987 cellular process

Structural information

Modbase 3D models: Tb09.160.5580  

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 9
Cumulative epitope score: 10.0
Normalized epitope score: 5.2
Percentile: 82.5 (this protein belongs to the top 17.5% proteins in the genome of Trypanosoma brucei, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL cluster: OG1.2_256
Number of Paralogs: 2
Arabidopsis thaliana At5g45775.2   |   OrthoMCL
Arabidopsis thaliana At4g01310.1   |   OrthoMCL
Arabidopsis thaliana At2g42740.1   |   OrthoMCL
Arabidopsis thaliana At3g58700.1   |   OrthoMCL
Arabidopsis thaliana At5g45775.1   |   OrthoMCL
Arabidopsis thaliana At4g18730.1   |   OrthoMCL
Brugia malayi Bm1_04440   |   OrthoMCL
Caenorhabditis elegans F07D10.1   |   OrthoMCL
Caenorhabditis elegans T22F3.4   |   OrthoMCL
Drosophila melanogaster CG7726-PA   |   OrthoMCL
Escherichia coli K12 gi|16131187|ref|NP_417767.1|   |   OrthoMCL
Homo sapiens ENSP00000270799   |   OrthoMCL
Leishmania major LmjF22.0030   |   OrthoMCL
Leishmania major LmjF04.0470   |   OrthoMCL
Mycobacterium leprae strain TN ML1847   |   OrthoMCL
Mus musculus ENSMUSP00000078670   |   OrthoMCL
Mus musculus ENSMUSP00000078001   |   OrthoMCL
Mycobacterium tuberculosis Rv0716   |   OrthoMCL
P. falciparum 3D7 PF07_0079   |   OrthoMCL
Plasmodium vivax Pv096340   |   OrthoMCL
Saccharomyces cerevisiae YGR085C   |   OrthoMCL
Saccharomyces cerevisiae YPR102C   |   OrthoMCL
Saccharomyces cerevisiae YDR237W   |   OrthoMCL
Schistosoma mansoni Smp_050940.2   |   OrthoMCL
Schistosoma mansoni Smp_050940.1   |   OrthoMCL
Trypanosoma brucei Tb09.160.5580 (this record).   |   OrthoMCL
Trypanosoma brucei Tb09.160.5590   |   OrthoMCL
Trypanosoma cruzi Tc00.1047053508197.10
Toxoplasma gondii 583.m00014   |   OrthoMCL
Wolbachia endosymbiont of Brugia malayi Wbm0329   |   OrthoMCL

Essentiality Tb09.160.5580 has essentiality data
Gene/Ortholog: mtu728 (OG1.2_256); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: eco3190 (OG1.2_256); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco3190 (OG1.2_256); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3190 (OG1.2_256); Phenotype: essential; Source study: keio
Gene/Ortholog: eco3190 (OG1.2_256); Phenotype: essential; Source study: shigen
Gene/Ortholog: cel16038 (OG1.2_256); Phenotype: Embryonic Lethal/Arrest; Source study: neb
Gene/Ortholog: cel16038 (OG1.2_256); Phenotype: Larval/Adult Lethal/Arrest; Source study: neb
Gene/Ortholog: cel16038 (OG1.2_256); Phenotype: Growth Defect; Source study: neb
Gene/Ortholog: cel16038 (OG1.2_256); Phenotype: Sterility; Source study: neb
Gene/Ortholog: cel5552 (OG1.2_256); Phenotype: Sterility; Source study: neb
Gene/Ortholog: cel5552 (OG1.2_256); Phenotype: Larval/Adult Lethal/Arrest; Source study: neb
Gene/Ortholog: cel5552 (OG1.2_256); Phenotype: Embryonic Lethal/Arrest; Source study: neb
Gene/Ortholog: cel5552 (OG1.2_256); Phenotype: Growth Defect; Source study: neb
Gene/Ortholog: cel16038 (OG1.2_256); Phenotype: Embryonic Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel16038 (OG1.2_256); Phenotype: Larval/Adult Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel16038 (OG1.2_256); Phenotype: Sterility; Source study: wormbase
Gene/Ortholog: cel5552 (OG1.2_256); Phenotype: Embryonic Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel5552 (OG1.2_256); Phenotype: Larval/Adult Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel5552 (OG1.2_256); Phenotype: Sterility; Source study: wormbase

[+/–]   Show essentiality data references.

Phenotypes (curated)

No manually curated information for this target.

Druggability

Mean compound desirability (max is 1):
Mean number of compounds:

Associated compounds

Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.

Do send us a note: if you have information about compounds for this gene.

No chemical compound is associated with this gene.

If you have information about compounds for this gene, please enter them in a user comment (see below) or contact us.

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic references

No literature references are available for this gene.

If you have references for this gene, please enter them in a user comment (below) or contact us.

User comments

No user comments are available for this gene.

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