Detailed view for Tb10.70.5100

Basic information

TDR Targets ID: 10115
Trypanosoma brucei, lysosomal alpha-mannosidase precursor, putative

Source Database / ID: GeneDB / Tb10.70.5100

pI: 6.9 | Length (AA): 997 | MW (Da): 111749 | Number of Paralogs: 1 | -.-.-.-

Signal peptide: Y | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF01074   Glycosyl hydrolases family
PF07748   Glycosyl hydrolases family

Gene Ontology

Biological Process:
GO:0005975   carbohydrate metabolic process   [+/–] show term definition

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology

Cellular component:
GO:0005764   lysosome   [+/–] show term definition

Any of a group of related cytoplasmic, membrane bound organelles that are found in most animal cells and that contain a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology

Molecular Function:
GO:0004559   alpha-mannosidase activity   [+/–] show term definition

Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

GO:0008150 biological_process
GO:0016787 hydrolase activity

Structural information

Modbase 3D models: Tb10.70.5100  

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 41
Cumulative epitope score: 45.9
Normalized epitope score: 4.6
Percentile: 55.1 (this protein belongs to the top 44.9% proteins in the genome of Trypanosoma brucei, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL cluster: OG1.2_2853
Number of Paralogs: 1
Arabidopsis thaliana At5g13980.1   |   OrthoMCL
Arabidopsis thaliana At3g26720.1   |   OrthoMCL
Arabidopsis thaliana At5g66150.1   |   OrthoMCL
Arabidopsis thaliana At5g13980.2   |   OrthoMCL
Brugia malayi Bm1_32610   |   OrthoMCL
Caenorhabditis elegans F55D10.1   |   OrthoMCL
Drosophila melanogaster CG9463-PA   |   OrthoMCL
Drosophila melanogaster CG9465-PA   |   OrthoMCL
Drosophila melanogaster CG9466-PA   |   OrthoMCL
Drosophila melanogaster CG9468-PA   |   OrthoMCL
Drosophila melanogaster CG5322-PA   |   OrthoMCL
Drosophila melanogaster CG6206-PA   |   OrthoMCL
Drosophila melanogaster CG6206-PB   |   OrthoMCL
Homo sapiens ENSP00000221363   |   OrthoMCL
Mus musculus ENSMUSP00000034121   |   OrthoMCL
Schistosoma mansoni Smp_160310   |   OrthoMCL
Schistosoma mansoni Smp_119180   |   OrthoMCL
Schistosoma mansoni Smp_131580   |   OrthoMCL
Trypanosoma brucei Tb10.70.5100 (this record).   |   OrthoMCL
Trypanosoma cruzi Tc00.1047053506195.120
Trypanosoma cruzi Tc00.1047053506407.10

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes (curated)

No manually curated information for this target.

Druggability

Druggability index (max is 1): 0.8
Mean compound desirability (max is 1):
Mean number of compounds: 3

Associated compounds

Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.

Do send us a note: if you have information about compounds for this gene.

No chemical compound is associated with this gene.

If you have information about compounds for this gene, please enter them in a user comment (see below) or contact us.

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic references

No literature references are available for this gene.

If you have references for this gene, please enter them in a user comment (below) or contact us.

User comments

No user comments are available for this gene.

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